{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:37:10Z","timestamp":1760143030384,"version":"build-2065373602"},"reference-count":18,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidade de Bras\u00edlia","award":["23106.004000\/2024-81"],"award-info":[{"award-number":["23106.004000\/2024-81"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Reports on UCF in animals are still lacking in veterinary literature. Detailed clinical signs, laboratory findings, and follow-up information from the first cases of UCF in two ewes and two cows are provided. The cases occurred over a 12-year period. All ruminants presented a fistulous tract or perforated wound on the right ventral abdomen, emitting a foul-smelling secretion possibly associated with macerated fetal parts or placental remains. Laboratory findings included anemia, leukocytosis by neutrophilia, and hyperfibrinogenemia in one ewe, and hyperfibrinogenemia in one cow. Ovariohysterectomy and fistulectomy were performed in one ewe, while the other three ruminants were submitted for the removal of fetal parts and placental remains through the UCF. Two ewes died within 12\u201348 h, and the two Nelore cows had an uneventful recovery, achieving secondary intention healing within 30 to 35 days. As a never-reported or unnoticed disease of the reproductive tract, UCF is an unusual consequence of dead fetus retention in an end-stage pregnancy and a potentially life-threatening condition in ruminants, especially ewes. Further broad studies in large herds of cattle and small ruminant flocks must be conducted to estimate the incidence of UCF and ensure improvements in the diagnosis and knowledge of pathogenesis, aiming at prevention.<\/jats:p>","DOI":"10.3390\/ani14020344","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T06:49:31Z","timestamp":1705906171000},"page":"344","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utero-Cutaneous Fistula in Ruminants: Characterization of the First Cases in Ewes and Cows"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6895-7210","authenticated-orcid":false,"given":"Antonio Carlos Lopes","family":"C\u00e2mara","sequence":"first","affiliation":[{"name":"Large Animal Veterinary Teaching Hospital, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Bras\u00edlia 70910-970, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Peixoto","family":"Braga","sequence":"additional","affiliation":[{"name":"Independent Researcher, Bras\u00edlia 70760-517, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9784-4848","authenticated-orcid":false,"given":"Andrei Antonioni Guedes","family":"Fidelis","sequence":"additional","affiliation":[{"name":"Animal Reproduction Department, Univerity Center of Bras\u00edlia (CEUB), Bras\u00edlia 70790-075, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto Romualdo de Faria","family":"Dantas","sequence":"additional","affiliation":[{"name":"Independent Researcher, Bras\u00edlia 70760-517, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-4432","authenticated-orcid":false,"given":"Jos\u00e9 Renato Junqueira","family":"Borges","sequence":"additional","affiliation":[{"name":"Large Animal Veterinary Teaching Hospital, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Bras\u00edlia 70910-970, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-0856","authenticated-orcid":false,"given":"M\u00e1rcio Botelho de","family":"Castro","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Laboratory, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Bras\u00edlia 70910-970, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1136\/pgmj.69.816.822","article-title":"Uterocutaneous fistula","volume":"69","author":"Gupta","year":"1993","journal-title":"Postgrad. Med. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.radcr.2021.09.069","article-title":"Utero-cutaneous fistula following cesarean section: A case report","volume":"17","author":"Jadib","year":"2022","journal-title":"Radiol. Case Rep."},{"key":"ref_3","first-page":"157","article-title":"Uterocutaneous fistula following cesarean section: Successful management of a case","volume":"41","author":"Maddah","year":"2016","journal-title":"Iran. J. Med. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"176","DOI":"10.12691\/ajmcr-10-6-4","article-title":"Extremely rare case of utero-cutaneous fistula in post cesarean section setting with successful surgical management","volume":"10","author":"Shrateh","year":"2022","journal-title":"Am. J. Med. Case Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e00282","DOI":"10.1016\/j.crwh.2020.e00282","article-title":"Spontaneous utero-cutaneous fistula between a benign uterine leiomyoma and abdominal skin: A case report","volume":"29","author":"Anderson","year":"2021","journal-title":"Case Rep. Women\u2019s Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"214","DOI":"10.5114\/pm.2022.119263","article-title":"Utero-cutaneous fistula after caesarean section delivery: Diagnosis and management of a rare complication","volume":"21","author":"Etrusco","year":"2022","journal-title":"Menopause Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/1595-1103.194212","article-title":"Utero-cutaneous fistula following cesarean section","volume":"17","author":"Taingson","year":"2016","journal-title":"Niger. J. Surg. Res."},{"key":"ref_8","unstructured":"Feldman, B.F., Zinkl, J.G., and Jain, N.C. (2000). Schalm\u2019s Veterinary Hematology, Lippincott Williams & Wilkins. [5th ed.]."},{"key":"ref_9","unstructured":"Kaneko, J.J., Harvey, J., and Bruss, M. (2008). Clinical Biochemistry of Domestic Animals, Academic Press. [6th ed.]."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.jmig.2017.05.013","article-title":"Uteroabdominal wall fistula after cesarean section in a patient with prior colorectal resection for endometriosis: A case report and systematic review","volume":"24","author":"Chattot","year":"2017","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_11","first-page":"e14071","article-title":"Utero-cutaneous fistula as a rare complication after cesarean delivery: Case series","volume":"2","author":"Rezaei","year":"2017","journal-title":"J. Obstet. Gynecol. Cancer Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.srhc.2012.03.002","article-title":"Utero-cutaneous fistula after caesarean section secondary to red degeneration of intramural fibroid","volume":"3","author":"Lim","year":"2012","journal-title":"Sex. Rep. Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cvfa.2016.05.008","article-title":"Surgery of the umbilicus and related structures","volume":"32","author":"Baird","year":"2016","journal-title":"Vet. Clin. N. Am. Food Anim. Pract."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4142\/jvs.2007.8.2.185","article-title":"Surgical treatment for different forms of hernias in sheep and goats","volume":"8","author":"Ahmed","year":"2007","journal-title":"J. Vet. Sci."},{"key":"ref_15","first-page":"87","article-title":"Prolonged co-twin foetal retention in a sheep: Caused by hysterocele?","volume":"21","author":"Peker","year":"2015","journal-title":"Large Anim. Rev."},{"key":"ref_16","first-page":"291","article-title":"Traumatic lateral hysterocele complicated with intestinal adhesions in a pregnant goat","volume":"27","author":"Sharun","year":"2021","journal-title":"Large Anim. Rev."},{"key":"ref_17","first-page":"45","article-title":"Hysterocele along with false or secondary extrauterine pregnancy in a goat: A rare case presentation","volume":"8","author":"Kumar","year":"2018","journal-title":"Theriogenol. Insight"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Braun, U., Warislohner, S., Torgerson, P., Nuss, K., and Gerspach, C. (2018). Clinical and laboratory findings in 503 cattle with traumatic reticuloperitonitis. BMC Vet. Res., 14.","DOI":"10.1186\/s12917-018-1394-3"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/2\/344\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:47:00Z","timestamp":1760104020000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/2\/344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,22]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["ani14020344"],"URL":"https:\/\/doi.org\/10.3390\/ani14020344","relation":{},"ISSN":["2076-2615"],"issn-type":[{"type":"electronic","value":"2076-2615"}],"subject":[],"published":{"date-parts":[[2024,1,22]]}}}