{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:46:28Z","timestamp":1760143588547,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study aimed to evaluate the effect of the preemptive administration of amantadine on postoperative analgesia in cats undergoing ovariohysterectomy and its influence on the physiological parameters. Twenty healthy domestic cats scheduled to undergo ovariohysterectomy at the Santa Cruz State University, Ilh\u00e9us, were divided into two groups: the control group (Group C; n = 10) and the amantadine group (Group A; n = 10). The cats in Group C received placebo capsules 30 min prior to the standard anesthetic protocol, whereas those in Group A received 5 mg\/kg of amantadine orally 30 min prior to the standard anesthetic protocol. Postoperative pain was assessed using the visual analog scale and the UNESP-Botucatu multidimensional scale for the evaluation of postoperative pain in cats. The administration of amantadine had no effect on the physiological parameters evaluated. The pain scores in Group A were lower than those in Group C, indicating that the frequency of rescue analgesic administration cats in Group A was lower. That way, preemptive oral administration of amantadine at a dose of 5 mg\/kg was effective at controlling postoperative pain in cats undergoing ovariohysterectomy. Moreover, no adverse effects or alterations in the physiological patterns were observed in the treated animals.<\/jats:p>","DOI":"10.3390\/ani14040643","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T05:10:04Z","timestamp":1708405804000},"page":"643","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Preemptive Analgesia with Amantadine for Controlling Postoperative Pain in Cats Undergoing Ovariohysterectomy"],"prefix":"10.3390","volume":"14","author":[{"given":"Paula Elisa Brand\u00e3o","family":"Guedes","sequence":"first","affiliation":[{"name":"Postgraduate Program in Animal Science, State University of Santa Cruz (UESC), Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta\u00edsa Miranda","family":"Pinto","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Animal Science, State University of Santa Cruz (UESC), Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana\u00edna Maria Xavier","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Animal Science, State University of Santa Cruz (UESC), Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3544-1757","authenticated-orcid":false,"given":"Raquel Vieira","family":"Niella","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Animal Science, State University of Santa Cruz (UESC), Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Moreira","family":"dos Anjos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Animal Science, State University of Santa Cruz (UESC), Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica Nat\u00e1lia Silva","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Animal Science, State University of Santa Cruz (UESC), Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire Souza da Costa","family":"Marques","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Animal Science, State University of Santa Cruz (UESC), Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia Saraiva","family":"de Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Animal Science, State University of Santa Cruz (UESC), Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elis\u00e2ngela Barboza","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Sciences, State University of Santa Cruz (UESC), Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0795-5320","authenticated-orcid":false,"given":"M\u00e1rio S\u00e9rgio Lima","family":"de Lavor","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Sciences, State University of Santa Cruz (UESC), Ilh\u00e9us 45662-900, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1097\/j.pain.0000000000000613","article-title":"Updating the definition of pain","volume":"11","author":"Williams","year":"2016","journal-title":"Pain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tvjl.2018.05.004","article-title":"The neurobiology of acute pain","volume":"237","author":"Bell","year":"2018","journal-title":"Vet. 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