{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:44:43Z","timestamp":1782168283697,"version":"3.54.5"},"reference-count":41,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Intussusception is a frequent cause of mechanical ileus in cattle. Long-term survival has never been described and risk factors for mortality are scarcely documented. A retrospective cohort study on 241 cattle was conducted to determine survival of intussusception and identify risk factors for mortality. Clinical records were matched with the national cattle identification database. Information on possible predictors including clinical examination, ultrasonography, blood-gas analysis and surgery were collected. Survival analysis and decision tree analysis were used. Overall survival was 44.8% until discharge. Of all animals, 39.0% could complete their life cycle and were eligible for slaughter. Male animals and cattle &lt; 226 days old experienced a significantly higher mortality risk (hazard ratio [HR] = 2.1; 95% confidence interval [CI] = 1.4\u20133.0 and HR = 2.4; 95% CI = 1.7\u20133.4, respectively). The final model consisted of heart rate (&gt;95 beats per minute) and packed cell volume (&lt;36.5%) with sensitivity and specificity of 60.4% and 49.4%, respectively. A second model consisted of sex (male) and time to referral (&gt;4.5 days) with sensitivity and specificity of 88.0% and 65.6%, respectively. The long-term prognosis for intussusception in cattle appears to be fair. Factors identified in this study may aid in the decision-making process in cases with presumed intussusception to perform the surgery or opt for euthanasia.<\/jats:p>","DOI":"10.3390\/ani14050676","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T10:52:00Z","timestamp":1708512720000},"page":"676","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long-Term Survival in 241 Cases of Intussusception in Cattle and Factors Associated with Mortality"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-0699","authenticated-orcid":false,"given":"Laurens","family":"Chantillon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Reproduction and Population Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3546-1328","authenticated-orcid":false,"given":"Mathilde Laetitia","family":"Pas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Reproduction and Population Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieven","family":"Vlaminck","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anaesthesiology of Domestic Animals, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Pardon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Reproduction and Population Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"ref_1","first-page":"659","article-title":"Ileoileal Intussusception Associated with Coccidiosis in Sheep","volume":"46","author":"Tafti","year":"1999","journal-title":"J. Vet. Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/vr.147.3.78","article-title":"Intussusception as a Complication of Rectal Prolapse Replacement in a Ewe","volume":"147","author":"Shakespeare","year":"2000","journal-title":"Vet. Rec."},{"key":"ref_3","unstructured":"Pugh, D.G. (2002). Sheep & Goat Medicine, W.B. Saunders. [1st ed.]."},{"key":"ref_4","first-page":"1","article-title":"Mesenteric Tear (Rent), Jejunal Volvulus, Torsion and Entrapment in a Kalahari Red Nanny Goat: Post Mortem Case Report and Literature Review","volume":"17","author":"Mushonga","year":"2016","journal-title":"Glob. Vet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2460\/javma.1997.210.04.531","article-title":"Intussusception in Cattle: 336 Cases (1964\u20131993)","volume":"210","author":"Constable","year":"1997","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_6","first-page":"1918","article-title":"Intussusception in Goats","volume":"78","author":"Mitchell","year":"1983","journal-title":"Vet. Med. Small Anim. Clin."},{"key":"ref_7","first-page":"287","article-title":"Repeated Occurrence of Jejuno-Jejunal Intussusception in a Calf","volume":"50","author":"Pravettoni","year":"2009","journal-title":"Can. Vet. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/vr.89.16.426","article-title":"Intussusception in Cattle","volume":"89","author":"Pearson","year":"1971","journal-title":"Vet. Rec."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"645","DOI":"10.17221\/7185-VETMED","article-title":"Surgical Management of an Ileocecocolic Intussusception in a Korean Native Calf: A Case Report","volume":"58","author":"Lee","year":"2013","journal-title":"Vet. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0749-0720(15)30869-0","article-title":"Surgery of the Bovine Small Intestine","volume":"6","author":"Smith","year":"1990","journal-title":"Vet. Clin. N. Am. Food Anim. Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.21423\/bovine-vol0no21p33-40","article-title":"Ileus and Subileus in the Young Bovine Animal","volume":"21","author":"Dirksen","year":"1986","journal-title":"Bov. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"584387","DOI":"10.4061\/2011\/584387","article-title":"Usefulness and Limitation of Ultrasonography in the Diagnosis of Intestinal Intussusception in Cows","volume":"2011","author":"Imran","year":"2011","journal-title":"Vet. Med. Int."},{"key":"ref_13","unstructured":"Smith, B.P. (2015). Large Animal Internal Medicine, Elsevier Mosby. [5th ed.]."},{"key":"ref_14","first-page":"493","article-title":"Colonic Intussusception in a Holstein Calf","volume":"32","author":"Horne","year":"1991","journal-title":"Can. Vet. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1002\/vro2.58","article-title":"A Retrospective Review of Small Intestinal Intussusception in 126 Cattle in Switzerland","volume":"10","author":"Braun","year":"2023","journal-title":"Vet. Rec. Open"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1111\/jvim.15223","article-title":"Use of a National Identification Database to Determine the Lifetime Prognosis in Cattle with Necrotic Laryngitis and the Predictive Value of Venous PCO2","volume":"32","author":"Pardon","year":"2018","journal-title":"J. Vet. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/vr.137.9.209","article-title":"Ultrasonographic Examination of the Small Intestine of Cows with Ileus of the Duodenum, Jejunum or Ileum","volume":"137","author":"Braun","year":"1995","journal-title":"Vet. Rec."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/vr.136.10.239","article-title":"Ultrasonographic Examination of the Small Intestine of Cows","volume":"136","author":"Braun","year":"1995","journal-title":"Vet. Rec."},{"key":"ref_19","first-page":"173","article-title":"Sonographic Examinations of the Intestines in Calves","volume":"146","author":"Stocker","year":"2004","journal-title":"Schweiz. Arch. Tierheilkd."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.2042-3306.1986.tb03640.x","article-title":"Surgical Management of Intussusception in the Horse","volume":"18","author":"Edwards","year":"1986","journal-title":"Equine Vet. J."},{"key":"ref_21","first-page":"1","article-title":"Intussusception in Horses","volume":"34","author":"Nelson","year":"2012","journal-title":"Compend. Contin. Educ. Vet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.applanim.2015.08.023","article-title":"Pain Evaluation in Dairy Cattle","volume":"171","author":"Gleerup","year":"2015","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cvfa.2016.05.007","article-title":"Intestinal Surgery","volume":"32","author":"Desrochers","year":"2016","journal-title":"Vet. Clin. N. Am. Food Anim. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.21423\/bovine-vol1984no19p230-235","article-title":"Bovine Gastrointestinal Surgery: Abomasal Volvulus Intestinal Surgery","volume":"19","author":"Smith","year":"1984","journal-title":"Bov. Pract."},{"key":"ref_25","first-page":"32","article-title":"Intussusception Involving the Spiral Colon in a Calf","volume":"21","author":"Hamilton","year":"1980","journal-title":"Can. Vet. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1017\/S1751731113002140","article-title":"Welfare Implication of Measuring Heart Rate and Heart Rate Variability in Dairy Cattle: Literature Review and Conclusions for Future Research","volume":"8","author":"Jurkovich","year":"2014","journal-title":"Animal"},{"key":"ref_27","first-page":"413","article-title":"Prognostic Indicators in Cattle with Right-Sided Displacement of the Abomasum and Abomasal Volvulus","volume":"141","author":"Meylan","year":"1999","journal-title":"Schweiz. Arch. Tierheilkd."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Braun, U., Nuss, K., Warislohner, S., Reif, C., Oschlies, C., and Gerspach, C. (2020). Diagnostic Reliability of Clinical Signs in Cows with Traumatic Reticuloperitonitis and Abomasal Ulcers. BMC Vet. Res., 16.","DOI":"10.1186\/s12917-020-02515-z"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"697589","DOI":"10.3389\/fvets.2021.697589","article-title":"Development of a Colic Scoring System to Predict Outcome in Horses","volume":"8","author":"Farrell","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.3168\/jds.2017-13445","article-title":"Establishing Blood Gas Ranges in Healthy Bovine Neonates Differentiated by Age, Sex, and Breed Type","volume":"101","author":"Dillane","year":"2018","journal-title":"J. Dairy. Sci."},{"key":"ref_31","unstructured":"Weiss, D.J., and Wardrop, K.J. (2011). Schalm\u2019s Veterinary Hematology, John Wiley & Sons. [6th ed.]."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3390\/ruminants1010004","article-title":"Acute Abdominal Disorders in Dairy Cattle: What Can Clinicians Do under Field Conditions?","volume":"1","author":"Castillo","year":"2021","journal-title":"Ruminants"},{"key":"ref_33","first-page":"1351","article-title":"The Epidemiology of Bovine Respiratory Disease: What Is the Evidence for Predisposing Factors?","volume":"51","author":"Taylor","year":"2010","journal-title":"Can. Vet. J."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Pardon, B., Hostens, M., Duchateau, L., Dewulf, J., De Bleecker, K., and Deprez, P. (2013). Impact of Respiratory Disease, Diarrhea, Otitis and Arthritis on Mortality and Carcass Traits in White Veal Calves. BMC Vet. Res., 9.","DOI":"10.1186\/1746-6148-9-79"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/jvim.16607","article-title":"Sepsis and Survival in Critically Ill Calves: Risk Factors and Antimicrobial Use","volume":"37","author":"Pas","year":"2023","journal-title":"J. Vet. Intern. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0167-5877(89)90006-8","article-title":"Association of Age, Sex and Breed Factors in Acute Equine Colic: A Retrospective Study of 320 Cases Admitted to a Veterinary Teaching Hospital in the U.S.A","volume":"7","author":"Reeves","year":"1989","journal-title":"Prev. Vet. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3390\/ani5040395","article-title":"Metabolic Disorders in the Transition Period Indicate that the Dairy Cows\u2019 Ability to Adapt Is Overstressed","volume":"5","author":"Sundrum","year":"2015","journal-title":"Animals"},{"key":"ref_38","first-page":"30","article-title":"A Detailed Review of Transportation Stress in Livestock and Its Management Techniques","volume":"11","author":"Bhatt","year":"2021","journal-title":"Int. J. Livest. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.2460\/javma.1993.203.08.1178","article-title":"Small-Intestinal Volvulus in Cattle: 35 Cases (1967\u20131992)","volume":"203","author":"Anderson","year":"1993","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/j.1939-1676.2010.0548.x","article-title":"Diagnostic Accuracy of D-dimer and Other Peritoneal Fluid Analysis Measurements in Dairy Cows with Peritonitis","volume":"24","author":"Wittek","year":"2010","journal-title":"J. Vet. Intern. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3168\/jds.2013-6898","article-title":"Preoperative Cow-Side Lactatemia Measurement Predicts Negative Outcome in Holstein Dairy Cattle with Right Abomasal Disorders","volume":"97","author":"Boulay","year":"2014","journal-title":"J. Dairy. Sci."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/5\/676\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:02:32Z","timestamp":1760104952000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/5\/676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["ani14050676"],"URL":"https:\/\/doi.org\/10.3390\/ani14050676","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,21]]}}}