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The cuticle coloration of the brown (br) mutant is brown instead of black in wild\u2212type individuals. Therefore, this study aimed to identify and characterize the gene responsible for the br mutation. Genome resequencing with allele segregation measurement using Euclidean distance followed by Lowess regression analysis revealed that the color locus linked to the mutation was located on chromosome 11. A 2\u2212base deletion on exon 4 was identified in the g7628 (yellow) gene after genome assembly and sequence cloning. In addition, the cuticle color of the abdomen of worker bees changed from black to brown when a defect was induced in the yellow gene using short interfering RNA (siRNA); however, the survival rate did not decrease significantly. These results indicate that the yellow gene participated in the body pigmentation, and its defect was responsible for the br mutation. This study promotes the understanding of the molecular basis of body coloration in honeybees, enriching the molecular mechanisms underlying insect pigmentation.<\/jats:p>","DOI":"10.3390\/ani14060862","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T11:05:10Z","timestamp":1710155110000},"page":"862","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Whole-Genome Resequencing\u2212Based Qualitative Trait Locus Mapping Correlated yellow with the Mutant Color in Honeybees, Apis cerana cerana"],"prefix":"10.3390","volume":"14","author":[{"given":"Shanshan","family":"Shao","sequence":"first","affiliation":[{"name":"Honeybee Research Institute, Jiangxi Agricultural University, Nanchang 330045, China"},{"name":"Jiangxi Key Laboratory of Honeybee Biology and Beekeeping, Jiangxi Agricultural University, Zhimin Ave. 1101, Nanchang 330045, China"},{"name":"Institute for Quality & Safety and Standards of Agricultural Products Research, Jiangxi Academy of Agricultural Sciences, Nanlian Road 602, Nanchang 330200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5528-5099","authenticated-orcid":false,"given":"Qiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Honeybee Research Institute, Jiangxi Agricultural University, Nanchang 330045, China"},{"name":"Jiangxi Key Laboratory of Honeybee Biology and Beekeeping, Jiangxi Agricultural University, Zhimin Ave. 1101, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalin","family":"Pei","sequence":"additional","affiliation":[{"name":"Honeybee Research Institute, Jiangxi Agricultural University, Nanchang 330045, China"},{"name":"Jiangxi Key Laboratory of Honeybee Biology and Beekeeping, Jiangxi Agricultural University, Zhimin Ave. 1101, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Honeybee Research Institute, Jiangxi Agricultural University, Nanchang 330045, China"},{"name":"Jiangxi Key Laboratory of Honeybee Biology and Beekeeping, Jiangxi Agricultural University, Zhimin Ave. 1101, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilong","family":"Wang","sequence":"additional","affiliation":[{"name":"Honeybee Research Institute, Jiangxi Agricultural University, Nanchang 330045, China"},{"name":"Jiangxi Key Laboratory of Honeybee Biology and Beekeeping, Jiangxi Agricultural University, Zhimin Ave. 1101, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Honeybee Research Institute, Jiangxi Agricultural University, Nanchang 330045, China"},{"name":"Jiangxi Key Laboratory of Honeybee Biology and Beekeeping, Jiangxi Agricultural University, Zhimin Ave. 1101, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-8944","authenticated-orcid":false,"given":"Xujiang","family":"He","sequence":"additional","affiliation":[{"name":"Honeybee Research Institute, Jiangxi Agricultural University, Nanchang 330045, China"},{"name":"Jiangxi Key Laboratory of Honeybee Biology and Beekeeping, Jiangxi Agricultural University, Zhimin Ave. 1101, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9865-1623","authenticated-orcid":false,"given":"Xiaobo","family":"Wu","sequence":"additional","affiliation":[{"name":"Honeybee Research Institute, Jiangxi Agricultural University, Nanchang 330045, China"},{"name":"Jiangxi Key Laboratory of Honeybee Biology and Beekeeping, Jiangxi Agricultural University, Zhimin Ave. 1101, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyu","family":"Yan","sequence":"additional","affiliation":[{"name":"Honeybee Research Institute, Jiangxi Agricultural University, Nanchang 330045, China"},{"name":"Jiangxi Key Laboratory of Honeybee Biology and Beekeeping, Jiangxi Agricultural University, Zhimin Ave. 1101, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"vi","DOI":"10.1016\/j.cois.2016.08.004","article-title":"Editorial overview: Molecular physiology: Molecular basis of insect colors and patterns","volume":"17","author":"Fukatsu","year":"2016","journal-title":"Curr. 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