{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:59:27Z","timestamp":1760144367740,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Functioning Funds of the Catholic University of Cordoba"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>It has been described in some female mammalian species that postnatal androgenization causes reproductive structural and functional abnormalities. The objective of this study was to describe the clinical, ovulatory and genital effects of postnatal androgens in female dogs. Ten newborn female crossbred puppies were randomly assigned to: testosterone enanthate 18 mg\/100 g sc (TE; n = 5) or placebo sc (PL; n = 5). The puppies were physically followed up until puberty when ovulation was tested by serum progesterone. Then, ovariohysterectomies were performed, and genital tracts were grossly and histomorphometrically examined. At puberty, all the females had normal estrous behavior and ovulated without age and body weight differences. All TE puppies presented mild clitoris enlargement. Gross and microscopical ovarian examination did not reveal differences. Conversely, the endometrial area occupied by uterine glands as well as the height of the glandular and luminal epithelium were higher in the TE than in the PL group (&lt;0.01). The height of the endometrium and myometrial thickness did not differ between groups. It was concluded that a supraphysiological postnatal dose of testosterone did not affect ovulatory capacity, nor did it provoke gonadal histological alterations, although it caused an increased area of endometrial glands and a higher uterine epithelium.<\/jats:p>","DOI":"10.3390\/ani14071049","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T13:28:00Z","timestamp":1711891680000},"page":"1049","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-8193","authenticated-orcid":false,"given":"Cynthia","family":"Marchetti","sequence":"first","affiliation":[{"name":"Research Institute of Natural Resources & Sustainability Jos\u00e9 Sanchez Labrador S.J., Catholic University of C\u00f3rdoba, C\u00f3rdoba 5000, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Buenos Aires 2290, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariela","family":"Grisolia-Romero","sequence":"additional","affiliation":[{"name":"Research Institute of Natural Resources & Sustainability Jos\u00e9 Sanchez Labrador S.J., Catholic University of C\u00f3rdoba, C\u00f3rdoba 5000, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Buenos Aires 2290, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8447-4630","authenticated-orcid":false,"given":"Marcelo","family":"Priotto","sequence":"additional","affiliation":[{"name":"Small Animal Clinics, Faculty of Agricultural Sciences, Catholic University of C\u00f3rdoba, C\u00f3rdoba 5000, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9015-449X","authenticated-orcid":false,"given":"Marcela","family":"Faya","sequence":"additional","affiliation":[{"name":"Research Institute of Natural Resources & Sustainability Jos\u00e9 Sanchez Labrador S.J., Catholic University of C\u00f3rdoba, C\u00f3rdoba 5000, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Buenos Aires 2290, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1681-8590","authenticated-orcid":false,"given":"Cristina","family":"Gobello","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Buenos Aires 2290, Argentina"},{"name":"Center of Reproductive Physiology, Faculty of Veterinary Sciences, National University of La Plata, La Plata 1900, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/rda.12306","article-title":"Suppression of fertility in adult dogs","volume":"49","author":"Maenhoudt","year":"2014","journal-title":"Reprod. 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