{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:26:19Z","timestamp":1787934379973,"version":"build-2784847793"},"reference-count":72,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AgResearch Strategic Science Investment Fund (SSIF)"},{"name":"AgResearch SSIF International Linkage Fund"},{"name":"Scotland\u2019s Rural College (SRUC)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Placental nutrient transport capacity influences fetal growth and development; however, it is affected by environmental factors, which are poorly understood. The objective of this study was to understand the impact of the ovine placentome morphological subtype, tissue type, and maternal parenteral supplementation of arginine mono-hydrochloride (Arg) on nutrient transport capacity using a gene expression approach. Placentomal tissues of types A, B, and C morphologic placentome subtypes were derived from 20 twin-bearing ewes, which were infused thrice daily with Arg (n = 9) or saline (Ctrl, n = 11) from 100 to 140 days of gestation. Samples were collected at day 140 of gestation. Expression of 31 genes involved in placental nutrient transport and function was investigated. Differential expression of specific amino acid transporter genes was found in the subtypes, suggesting a potential adaptive response to increase the transport capacity. Placentomal tissues differed in gene expression, highlighting differential transport capacity. Supplementation with Arg was associated with differential expressions of genes involved in amino acid transport and angiogenesis, suggesting a greater nutrient transport capacity. Collectively, these results indicate that the morphological subtype, tissue type, and maternal Arg supplementation can influence placental gene expression, which may be an adaptive response to alter the transport capacity to support fetal growth in sheep.<\/jats:p>","DOI":"10.3390\/ani14091294","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T08:08:32Z","timestamp":1714032512000},"page":"1294","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Increasing the Understanding of Nutrient Transport Capacity of the Ovine Placentome"],"prefix":"10.3390","volume":"14","author":[{"given":"Cathrine","family":"Erichsen","sequence":"first","affiliation":[{"name":"AgResearch Ltd., Grasslands Research Centre, Private Bag 11008, Palmerston North 4474, New Zealand"},{"name":"Scotland\u2019s Rural College (SRUC), Easter Bush Campus, Edinburgh EH25 9RG, UK"},{"name":"Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Heiser","sequence":"additional","affiliation":[{"name":"AgResearch Ltd., Grasslands Research Centre, Private Bag 11008, Palmerston North 4474, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neville","family":"Haack","sequence":"additional","affiliation":[{"name":"AgResearch Ltd., Grasslands Research Centre, Private Bag 11008, Palmerston North 4474, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maclean","sequence":"additional","affiliation":[{"name":"AgResearch Ltd., Grasslands Research Centre, Private Bag 11008, Palmerston North 4474, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7511-2056","authenticated-orcid":false,"given":"Cathy Mary","family":"Dwyer","sequence":"additional","affiliation":[{"name":"Scotland\u2019s Rural College (SRUC), Easter Bush Campus, Edinburgh EH25 9RG, UK"},{"name":"Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4806-0323","authenticated-orcid":false,"given":"Sue","family":"McCoard","sequence":"additional","affiliation":[{"name":"AgResearch Ltd., Grasslands Research Centre, Private Bag 11008, Palmerston North 4474, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1079\/NRR200239","article-title":"Regulation of Placental Nutrient Transport and Implications for Fetal Growth","volume":"15","author":"Bell","year":"2002","journal-title":"Nutr. 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