{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:06:39Z","timestamp":1760144799808,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Celiac plexus block (CPB) and neurolysis (CPN) are used for pain management in people suffering from abdominal tumours or chronic pancreatitis. The fluoroscopically guided approach common in human medicine has not been described in veterinary settings. The aim of this study was to describe a fluoroscopic approach to the celiac plexus (CP) in fresh pig cadavers. Twelve animals were included in the procedure. Cadavers were positioned in sternal position and, under fluoroscopic guidance, a Chiba needle was inserted parasagittal at 6 cm from the spinal midline at the level of the last thoracic vertebra. From the left side, the needle was directed medio-ventrally with a 45\u00b0 angle towards the T15 vertebral body; once the vertebral body was contacted, the needle was advanced 1 cm ventrally towards the midline. Iodinated contrast was injected to confirm the location. Following this, 2 mL of dye (China ink) was injected. A laparotomy was performed, and dyed tissue was dissected and prepared for both histochemical and immunohistochemical techniques. In 10 out of 12 samples submitted for histological evaluation, nervous tissue belonging to CP was observed. Fluoroscopy guidance allows for feasible access to the CP in swine cadavers in this study. Further studies are warranted to determine the efficacy of this technique in swine and other veterinary species.<\/jats:p>","DOI":"10.3390\/ani14101478","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T03:24:48Z","timestamp":1715829888000},"page":"1478","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Percutaneous Fluoroscopic-Guided Celiac Plexus Approach: Results in a Pig Cadaveric Model"],"prefix":"10.3390","volume":"14","author":[{"given":"Francesco","family":"Aprea","sequence":"first","affiliation":[{"name":"Hospital Veterinari Canis Mallorca, 07013 Palma, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Millan","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathology, School of Veterinary Medicine, University of Cordoba, 14071 Cordoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Tom\u00e1s","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria de las Islas Baleares (IdISBa), 07120 Palma, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma Sempere","family":"Campello","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria de las Islas Baleares (IdISBa), 07120 Palma, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocio Navarrete","family":"Calvo","sequence":"additional","affiliation":[{"name":"Animal Medicine and Surgery Department, School of Veterinary Medicine, University of Cordoba, 14071 Cordoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0504-0752","authenticated-orcid":false,"given":"Maria del Mar","family":"Granados","sequence":"additional","affiliation":[{"name":"Animal Medicine and Surgery Department, School of Veterinary Medicine, University of Cordoba, 14071 Cordoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.giec.2018.06.004","article-title":"Celiac plexus block and neurolysis: A Review","volume":"28","author":"Sachdev","year":"2018","journal-title":"Gastrointest. Endosc. Clin. N. Am."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3844\/ajavsp.2015.67.76","article-title":"Medical Abdominal Visceral Pain","volume":"10","author":"Catanzaro","year":"2015","journal-title":"Am. J. Anim. Vet. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/vaa.12326","article-title":"Preliminary study on attitudes, opinions and knowledge of Italian veterinarians with regard to abdominal visceral pain in dogs","volume":"43","author":"Catanzaro","year":"2016","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/ame2.12130","article-title":"Possible implications of animals model for the assessment of visceral pain","volume":"3","author":"Regmi","year":"2020","journal-title":"Anim. Models Exp. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-3-540-79090-7_2","article-title":"Visceral pain: The neurophysiological mechanism","volume":"194","author":"Sengupta","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1148\/rg.316115526","article-title":"CT-guided celiac plexus neurolysis: A review of anatomy, indications, technique, and tips for successful treatment","volume":"31","author":"Kambadakone","year":"2011","journal-title":"RadioGraphics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11916-020-00878-4","article-title":"A Comprehensive Review of the Celiac Plexus Block for the Management of Chronic Abdominal Pain","volume":"24","author":"Urits","year":"2020","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_8","first-page":"23","article-title":"Celiac and cranial mesenteric ganglia (celiac plexus) block in dogs: Preliminary cadaveric study using a blind technique (abstract)","volume":"42","author":"Ravasio","year":"2015","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_9","first-page":"216","article-title":"Celiac plexus block in equine ileus: A pilot study. Proceedings SiSVET, Perugia, Italia, Ed","volume":"69","author":"Rabbogliatti","year":"2015","journal-title":"SiSVET"},{"key":"ref_10","first-page":"87","article-title":"Erfahrungen mit Lokalanaesthesie bei Bauchopen ationen","volume":"43","author":"Kappis","year":"1914","journal-title":"Verh. Dtsch. Gas. Chir."},{"key":"ref_11","first-page":"379","article-title":"Celiac Plexus Block\u2014An old technique with New Developments","volume":"24","author":"Vig","year":"2021","journal-title":"Pain Physician"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s004640000173","article-title":"Development of a laparoscopic approach to neurolytic celiac plexus block in a porcine model","volume":"14","author":"Underwood","year":"2000","journal-title":"Surg. Endosc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1055\/s-0028-1119588","article-title":"Evaluation of endoscopic-ultrasound-guided celiac ganglion irradiation with iodine-125 seeds: A pilot study in porcine model","volume":"41","author":"Wang","year":"2009","journal-title":"Endoscopy"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3748\/wjg.v16.i6.728","article-title":"Endoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymer","volume":"16","author":"Obstein","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1055\/s-0037-1608861","article-title":"Celiac plexus block and neurolysis in the management of chronic upper abdominal pain","volume":"34","author":"Holzwanger","year":"2017","journal-title":"Semin. Interv. Radiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Basurto, O.X., Rigau, C.D., and Urrutia, G. (2013). Opioids for acute pancreatitis pain. Cochrane Database Syst. Rev., 7.","DOI":"10.1002\/14651858.CD009179.pub2"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1136\/gut.29.10.1402","article-title":"Effects of morphine on the human sphincter of Oddi","volume":"29","author":"Helm","year":"1988","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1080\/14737140.2018.1474103","article-title":"Challenges and concerns of persistent opioid use in cancer patients","volume":"18","author":"Manchikanti","year":"2018","journal-title":"Exp. Rev. Anticancer. Ther."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.vaa.2017.11.005","article-title":"A retrospective comparison of two analgesic strategies after uncomplicated tibial plateau levelling osteotomy in dogs","volume":"45","author":"Bini","year":"2018","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/jsap.12296","article-title":"Management of acute pancreatitis in dogs: A critical appraisal with focus on feeding and analgesia","volume":"56","author":"Mansfield","year":"2015","journal-title":"J. Small Anim. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1159\/000108958","article-title":"Pain in chronic pancreatitis: A salutogenic mechanism or a maladaptative brain response?","volume":"7","author":"Fregni","year":"2007","journal-title":"Pancreatology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2147\/JPR.S244173","article-title":"The Modified WHO Analgesic Ladder: Is It Appropriate for Chronic Non-Cancer Pain?","volume":"17","author":"Yang","year":"2020","journal-title":"J. Pain Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0304-3959(88)90124-8","article-title":"The percutaneous anterior approach to the celiac plexus using CT guidance","volume":"34","year":"1988","journal-title":"Pain"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2214\/ajr.160.3.8430543","article-title":"Celiac plexus block: Efficacy and safety of the anterior approach","volume":"160","author":"Romanelli","year":"1993","journal-title":"Am. J. Roentgenol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0304-3959(83)90148-3","article-title":"A new approach to the neurolytic block of the coeliac plexus: The transaortic technique","volume":"16","author":"Ischia","year":"1983","journal-title":"Pain"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/papr.12107","article-title":"Bedside ultrasound-guided celiac plexus neurolysis in upper abdominal cancer patients: A randomized, prospective study for comparison of percutaneous bilateral paramedian vs. unilateral paramedian needle-insertion technique","volume":"14","author":"Bhatnagar","year":"2014","journal-title":"Pain Pract."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.bjan.2018.12.005","article-title":"Single needle versus double needle celiac trunk neurolysis in abdominal malignancy pain management: A randomized controlled trial","volume":"69","author":"Abdelghaffar","year":"2019","journal-title":"Rev. Bras. Anestesiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Trujanovic, R., Otero, P.E., Marhofer, P., Auer, U., and Kau, S. (2021). Proximal Perineural Femoral Nerve Injection in Pigs Using an Ultrasound-Guided Lateral Subiliac Approach-A Cadaveric Study. Animals, 11.","DOI":"10.3390\/ani11061759"},{"key":"ref_29","first-page":"131","article-title":"Utilizaci\u00f3n de la aguja de Chiba en el tratamiento analg\u00e9sico del c\u00e1ncer de p\u00e1ncreas","volume":"68","author":"Montero","year":"1985","journal-title":"Rev. Esp. Enferm. Apar. Dig."},{"key":"ref_30","first-page":"290","article-title":"Neurolytic celiac plexus block for treatment of cancer pain: A meta-analysis","volume":"80","author":"Eisenberg","year":"1995","journal-title":"Anesth. Analg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/papr.12083","article-title":"Celiac plexus block for treatment of pain associated with pancreatic cancer: A meta-analysis","volume":"14","author":"Zhong","year":"2014","journal-title":"Pain Pract."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.vaa.2019.12.005","article-title":"Description of ultrasound\u2013guided quadratus lumborum block technique and evaluation of injectate spread in canine cadavers","volume":"47","author":"Garbin","year":"2020","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"497","DOI":"10.36076\/ppj.2018.5.497","article-title":"Low volume neurolytic retrocrural celiac plexus block for visceral cancer pain: Retrospective review of 507 patients with severe malignancy related pain due to primary abdominal cancer or metastatic disease","volume":"21","author":"Rahman","year":"2018","journal-title":"Pain Physician"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.vaa.2020.01.003","article-title":"Effect of contrast and local anesthetic on dye spread following transversus abdominis plane injection in dog cadavers","volume":"47","author":"Whyte","year":"2020","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s11916-013-0394-z","article-title":"Celiac plexus block in the management of chronic abdominal pain","volume":"18","author":"Rana","year":"2014","journal-title":"Curr. Pain Headache Rep."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/10\/1478\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:43:04Z","timestamp":1760107384000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/10\/1478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,16]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["ani14101478"],"URL":"https:\/\/doi.org\/10.3390\/ani14101478","relation":{},"ISSN":["2076-2615"],"issn-type":[{"type":"electronic","value":"2076-2615"}],"subject":[],"published":{"date-parts":[[2024,5,16]]}}}