{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:40:45Z","timestamp":1791517245325,"version":"4.3.4"},"reference-count":41,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T00:00:00Z","timestamp":1716595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Pasteurellosis, a disease caused by Pasteurella multocida, is responsible for economic losses in rabbit industrial farms due to rhinitis, conjunctivitis, pneumonia, metritis, mastitis, orchitis, subcutaneous abscesses, otitis, encephalitis, and septicaemic forms. Although the occurrence of the disease is conditioned by predisposing factors that affect the rabbit immune response, the strains of P. multocida involved in the infection may have a different pathogenic ability. Therefore, typing of strains spread among the rabbits is important to assess their pathogenic potential. The aim of this study is to investigate the P. multocida strains responsible for disease in rabbit industrial farms. A total of 114 strains identified from different lesions were serotyped. Additionally, the presence of virulence-associated genes was investigated using three PCR (polymerase chain reaction) protocols. Capsular type A was prevalently found in strains from respiratory lesions while types D and F in those from metritis, mastitis, and other lesions. Different associations between some virulence-associated genes and both capsular type and lesions found in rabbits were detected. The presence of 8 virulence-associated genes seems to increase the occurrence of metritis. In addition, strains belonging to capsular type A and responsible for respiratory disorders especially, were found equipped with 10 and 11 virulence-associated genes. Nevertheless, the presence of strains responsible only for rhinitis was also detected among the latter, suggesting that the pathogenic ability of the bacteria depends on the expression rather than the presence of a gene.<\/jats:p>","DOI":"10.3390\/ani14111569","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T05:14:02Z","timestamp":1716786842000},"page":"1569","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characterisation of Pasteurella multocida Strains from Different Lesions in Rabbits"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4636-3547","authenticated-orcid":false,"given":"Francesco","family":"D\u2019Amico","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, University of Bari, S. P. Casamassima km 3, 70010 Valenzano, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3813-5501","authenticated-orcid":false,"given":"Davide","family":"Messina","sequence":"additional","affiliation":[{"name":"Division of Veterinary Clinical Science, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-1903","authenticated-orcid":false,"given":"Gaia","family":"Casalino","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Bari, S. P. Casamassima km 3, 70010 Valenzano, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Schiavitto","sequence":"additional","affiliation":[{"name":"Italian Rabbit Breeders Association, ANCI, Contrada Giancola snc, 71030 Volturara Appula, FG, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Bove","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Bari, S. P. Casamassima km 3, 70010 Valenzano, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Romito","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Bari, S. P. Casamassima km 3, 70010 Valenzano, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Paolo","family":"D\u2019Onghia","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Bari, S. P. Casamassima km 3, 70010 Valenzano, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3961-585X","authenticated-orcid":false,"given":"Antonio","family":"Camarda","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Bari, S. P. Casamassima km 3, 70010 Valenzano, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9625-2920","authenticated-orcid":false,"given":"Elena","family":"Circella","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Bari, S. P. Casamassima km 3, 70010 Valenzano, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2007.10.018","article-title":"Diagnostic and typing options for investigating diseases associated with Pasteurella multocida","volume":"128","author":"Dziva","year":"2008","journal-title":"Vet. Microbiol."},{"key":"ref_2","first-page":"48","article-title":"The type specific capsular antigen of Pasteurella multocida","volume":"30","author":"Carter","year":"1952","journal-title":"Can. J. Med. Sci."},{"key":"ref_3","first-page":"437","article-title":"Capsular and somatic types of Pasteurella multocida from rabbits","volume":"46","author":"Chengappa","year":"1982","journal-title":"Can. J. Med. Comp."},{"key":"ref_4","unstructured":"Boyce, J.D., Harper, M., Wilkie, I.W., and Adler, B. (2010). 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