{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:23:06Z","timestamp":1787851386859,"version":"build-2784847793"},"reference-count":37,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Phibro Animal Health Corporation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study assessed the impact of Magni-Phi Ultra (MPU) inclusion on intestinal integrity and immunity in broiler chickens challenged with coccidia during peak and recovery phases. A total of 128 male Ross 708 broiler chicks were randomly allotted to one of four treatment groups (four chicks\/cage). Treatments included an uninfected control (UUC); a coccidial challenge (CC) infected control (IUC); a CC fed salinomycin at 66 ppm (SAL); and a CC fed Magni-Phi Ultra at 0.11 g\/kg of diet (MPU). At 16 days post-hatch, all birds in the CC groups were orally gavaged with a 3\u00d7 dose of a live coccidia vaccine. At 5 dpi, the birds fed MPU and SAL showed decreased plasma FITC-d, oocyte shedding, and lesion scores and higher BWG compared to the IUC birds (p &lt; 0.05). Jejunum IL-17, IL-10, and IFN-\u03d2 mRNA expression was higher in the IUC compared to the UUC (p &lt; 0.05) group at 5 dpi. At 12 dpi, the birds fed MPU or SAL had lower plasma FITC-d and jejunum IFN-\u03d2 and IL-10 mRNA expression compared to the IUC birds (p &lt; 0.05). This study indicates that MPU supports intestinal integrity and mucosal immune responses during the peak and recovery phases of infection, which may lead to improved health and performance.<\/jats:p>","DOI":"10.3390\/ani14121737","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T08:49:03Z","timestamp":1718009343000},"page":"1737","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Dietary Inclusion of a Proprietary Combination of Quillaja saponaria and Yucca schidigera on Intestinal Permeability and Immune Response in Broiler Chickens during a Coccidia Challenge"],"prefix":"10.3390","volume":"14","author":[{"given":"Kari","family":"Saddoris-Clemons","sequence":"first","affiliation":[{"name":"Phibro Animal Health Corporation, Teaneck, NJ 07666, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saheed","family":"Osho","sequence":"additional","affiliation":[{"name":"Phibro Animal Health Corporation, Teaneck, NJ 07666, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Garcia","sequence":"additional","affiliation":[{"name":"Phibro Animal Health Corporation, Teaneck, NJ 07666, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Humphrey","sequence":"additional","affiliation":[{"name":"Phibro Animal Health Corporation, Teaneck, NJ 07666, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13567-020-00837-2","article-title":"Re-calculating the cost of coccidiosis in chickens","volume":"51","author":"Blake","year":"2020","journal-title":"Vet. 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