{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:31:46Z","timestamp":1787027506301,"version":"build-2736575974"},"reference-count":84,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Danish Cooperation for Environment in the Arctic (Dancea)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Ringed seals are consumed in Greenland and are therefore included as a key biomonitoring species with the focus on pollution exposure and health effects. Ringed seals in Central West Greenland (Qeqertarsuaq) and in North West Greenland (Qaanaaq) were analyzed for metal concentrations in the liver and histological changes in the liver and kidney. The mean liver concentration of mercury in Qaanaaq was 3.73 \u00b1 5.01 \u00b5g\/g ww (range: 0.28\u201323.29 \u00b5g\/g ww), and the mean cadmium concentration was 7.80 \u00b1 8.95 \u00b5g\/g ww (range: 0.013\u201338.79 \u00b5g\/g ww). For Qeqertarsuaq, the liver concentration of mercury was 1.78 \u00b1 1.70 \u00b5g\/g ww (range: 0.45\u20138.00 \u00b5g\/g ww) and the mean cadmium concentration was 11.58 \u00b1 6.32 \u00b5g\/g ww (range: 0.11\u201325.45 \u00b5g\/g ww). Age had a positive effect on the liver concentrations of metals, while no effect was found for sex or histological changes. The prevalence of histological changes in liver tissue decreased in the following order: random pattern mononuclear cell infiltration (92.1%), portal cell infiltration (68.4%), hepatic intracellular fat (18.4%), portal fibrosis (7.9%), focal hepatic fibrosis (7.9%), bile duct hyperplasia\/fibrosis (7.9%) and lipid granuloma (2.6%). For kidney tissue, the prevalence of histological changes decreased in the following order: glomerular mesangial deposits (54.1%) &gt; glomerular basement membrane thickening (45.9%) &gt; THD (40%) &gt; tubular hyaline casts (14.0%) &gt; glomerular atrophy (13.5%) &gt; dilated tubules (13.5%) &gt; glomerular hyper-cellularity (10.8%) &gt; mononuclear cell infiltrations (8.1%).<\/jats:p>","DOI":"10.3390\/ani14121739","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T08:49:03Z","timestamp":1718009343000},"page":"1739","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Element Concentrations and Histopathology of Liver and Kidney in West Greenland Ringed Seals (Pusa hispida)"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3102-4844","authenticated-orcid":false,"given":"Emilie U.","family":"Andersen-Ranberg","sequence":"first","affiliation":[{"name":"Arctic Research Centre (ARC), Department of Ecoscience, Faculty of Technological Sciences, Aarhus University, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark"},{"name":"Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrl\u00e6gevej 16, DK-1870 Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1539-9491","authenticated-orcid":false,"given":"Pall S.","family":"Leifsson","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 3, DK-1870 Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank F.","family":"Rig\u00e9t","sequence":"additional","affiliation":[{"name":"Arctic Research Centre (ARC), Department of Ecoscience, Faculty of Technological Sciences, Aarhus University, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7680-9920","authenticated-orcid":false,"given":"Jens","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"Arctic Research Centre (ARC), Department of Ecoscience, Faculty of Technological Sciences, Aarhus University, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Andersen","sequence":"additional","affiliation":[{"name":"Hunters Science, R\u00e5dmandsgade 55, DK-2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0084-9122","authenticated-orcid":false,"given":"Aage Kristian Olsen","family":"Alstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus, Denmark"},{"name":"Department of Nuclear medicine & PET, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune","family":"Dietz","sequence":"additional","affiliation":[{"name":"Arctic Research Centre (ARC), Department of Ecoscience, Faculty of Technological Sciences, Aarhus University, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5723-5263","authenticated-orcid":false,"given":"Christian","family":"Sonne","sequence":"additional","affiliation":[{"name":"Arctic Research Centre (ARC), Department of Ecoscience, Faculty of Technological Sciences, Aarhus University, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"key":"ref_1","unstructured":"AMAP (2003). AMAP Assessment 2002. Human Health in the Arctic, Arctic Monitoring and Assessment Programme (AMAP)."},{"key":"ref_2","unstructured":"AMAP (2005). AMAP Assessment 2002: Heavy Metals in the Arctic, Arctic Monitoring and Assessment Programme (AMAP). 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