{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:08:45Z","timestamp":1791256125685,"version":"4.1.0"},"reference-count":63,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072768"],"award-info":[{"award-number":["32072768"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This experiment was carried out to investigate the effect of pterostilbene (PTE) supplementation in feed on Arbor Acres broilers in terms of serum biochemical parameters, immune and inflammatory responses, antioxidant status, and intestinal morphological structure. For a duration of 42 days, a total of 480 1-day-old Arbor Acres broilers were randomly divided into four groups. Each group was assigned to receive either the basal diet or the basal diet supplemented with 200, 400, or 600 mg\/kg of PTE. Each treatment consisted of eight replicates, with 15 chicks per replicate. In comparison with the control group, three PTE treatments significantly increased the lymphocyte transformation rate in the spleen of broilers. The automated biochemical analysis, enzyme-linked immunosorbent assay, and RT-qPCR analysis kits found that 400 mg\/kg of PTE significantly increased the serum levels of complement C3, IL-4, and iNOS; reduced the serum levels of IL-6, TNF-\u03b1, and mRNA levels of the genes IL-6, IL-8, TNF-\u03b1, NLRP3, and IFN-\u03b3; significantly improved the activities of antioxidant enzymes including CAT, GSH-Px, and T-SOD in the jejunum; and significantly reduced the MDA contents in the serum and jejunum of broilers. Nikon microscope observations and ImagePro Plus 6.0 measure results found that 400 mg\/kg of PTE supplementation significantly reduced the relative length and weight of the jejunum and improved the jejunal villi structure, resulting in increased intestinal villi, deepened crypt, and an enhanced ratio of villi height to crypt depth (VH\/CD). RT-qPCR and Western blot found that dietary PTE also resulted in increased mRNA levels of the genes Claudin-2, Occludin, ZO-1, and Sirt1, and decreased NF-\u03baB protein levels in the jejunum. The results of this study demonstrated that dietary PTE improved the immune function and intestinal health of broilers by reducing inflammation and increasing the antioxidant capacity of the animals.<\/jats:p>","DOI":"10.3390\/ani14131851","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T03:53:43Z","timestamp":1719201223000},"page":"1851","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Effects of Dietary Pterostilbene on the Immune Response, Antioxidant Function, and Jejunal Structure of Broilers"],"prefix":"10.3390","volume":"14","author":[{"given":"Zesheng","family":"Yin","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5599-116X","authenticated-orcid":false,"given":"Xue","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehong","family":"Chai","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300222, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-5913","authenticated-orcid":false,"given":"Xingjun","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1016\/j.sjbs.2020.06.027","article-title":"Enhanced modulation of gut microbial dynamics affecting body weight in birds triggered by natural growth promoters administered in conventional feed","volume":"27","author":"Rashid","year":"2020","journal-title":"SAUDI J. Biol. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sejian, V., Silpa, M., Reshma Nair, M., Devaraj, C., Krishnan, G., Bagath, M., Chauhan, S., Suganthi, R., Fonseca, V., and K\u00f6nig, S. (2021). Heat stress and goat welfare: Adaptation and production considerations. Animals, 11.","DOI":"10.3390\/ani11041021"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Chai, X., Sun, X., Qi, X., Shan, A., and Feng, X. (2024). Food Security: Nutritional characteristics, feed utilization status and limiting factors of aged brown rice. Agriculture, 14.","DOI":"10.3390\/agriculture14060858"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3389\/fphar.2019.00289","article-title":"A Symphytum officinale root extract exerts anti-inflammatory properties by affecting two distinct steps of NF-\u03baB signaling","volume":"10","author":"Seigner","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Moreno, R.M., Jimenez, V., and Monroy, F.P. (2019). Impact of Binge Alcohol Intoxication on the Humoral Immune Response during Burkholderia spp. Infections. Microorganisms, 7.","DOI":"10.3390\/microorganisms7050125"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zhang, J., Sun, X., Chai, X., Jiao, Y., Sun, J., Wang, S., Yu, H., and Feng, X. (2024). Curcumin Mitigates Oxidative Damage in Broiler Liver and Ileum Caused by Aflatoxin B1-Contaminated Feed through Nrf2 Signaling Pathway. Animals, 14.","DOI":"10.3390\/ani14030409"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Guan, P., Yu, H., Wang, S., Sun, J., Chai, X., Sun, X., Qi, X., Zhang, R., Jiao, Y., and Li, Z. (2024). Dietary rutin alleviated the damage by cold stress on inflammation reaction, tight junction protein and intestinal microbial flora in the mice intestine. J. Nutr. Biochem., 130.","DOI":"10.1016\/j.jnutbio.2024.109658"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Meng, Q., Guo, T., Li, G., Sun, S., He, S., Cheng, B., Shi, B., and Shan, A. (2018). Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1. J. Anim. Sci. Biotechnol., 9.","DOI":"10.1186\/s40104-018-0248-y"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1017\/S095442241700021X","article-title":"Resveratrol and inflammatory bowel disease: The evidence so far","volume":"31","author":"Nunes","year":"2018","journal-title":"Nutr. Res. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Dyck, G.J., Raj, P., Zieroth, S., Dyck, J.R., and Ezekowitz, J.A. (2019). The effects of resveratrol in patients with cardiovascular disease and heart failure: A narrative review. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040904"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1133167","DOI":"10.3389\/fendo.2023.1133167","article-title":"Gut microbial characteristical comparison reveals potential anti-aging function of Dubosiella newyorkensis in mice","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Wang, L., Lai, C., Li, D., Luo, Z., Liu, L., Jiang, Y., and Li, L. (2022). Lecithin-polysaccharide self-assembled microspheres for resveratrol delivery. Antioxidants, 11.","DOI":"10.3390\/antiox11091666"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/biof.1396","article-title":"Resveratrol, pterostilbene, and dementia","volume":"44","author":"Lange","year":"2018","journal-title":"Biofactors"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/biof.1410","article-title":"Metabolism and pharmacokinetics of resveratrol and pterostilbene","volume":"44","author":"Wang","year":"2018","journal-title":"Biofactors"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.freeradbiomed.2008.08.001","article-title":"Regulation of cellular signals from nutritional molecules: A specific role for phytochemicals, beyond antioxidant activity","volume":"45","author":"Virgili","year":"2008","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"skaa328","DOI":"10.1093\/jas\/skaa328","article-title":"Protective effects of pterostilbene against hepatic damage, redox imbalance, mitochondrial dysfunction, and endoplasmic reticulum stress in weanling piglets","volume":"98","author":"Zhang","year":"2020","journal-title":"J. Anim. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1016\/j.psj.2020.01.021","article-title":"Pterostilbene as a protective antioxidant attenuates diquat-induced liver injury and oxidative stress in 21-day-old broiler chickens","volume":"99","author":"Chen","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1021\/jf304487v","article-title":"The inhibitory effect of pterostilbene on inflammatory responses during the interaction of 3T3-L1 adipocytes and RAW 264.7 macrophages","volume":"61","author":"Hsu","year":"2013","journal-title":"J. Agric. Food. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e156255","DOI":"10.1172\/jci.insight.156255","article-title":"Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis","volume":"7","author":"Klingensmith","year":"2022","journal-title":"JCI Insight"},{"key":"ref_20","first-page":"132025","article-title":"CXCR2, as a key regulatory gene of HDP-PG-1, maintains intestinal mucosal homeostasis","volume":"269","author":"Yan","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3389\/fphar.2020.01249","article-title":"Resveratrol modulates the gut microbiota and inflammation to protect against diabetic nephropathy in mice","volume":"11","author":"Cai","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8258354","DOI":"10.1155\/2023\/8258354","article-title":"Pterostilbene Confers Protection against Diquat-Induced Intestinal damage with potential regulation of redox status and ferroptosis in broiler chickens","volume":"2023","author":"Chen","year":"2023","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zhang, H., Chen, Y., Chen, Y., Ji, S., Jia, P., Li, Y., and Wang, T. (2020). Comparison of the protective effects of resveratrol and pterostilbene against intestinal damage and redox imbalance in weanling piglets. J. Anim. Sci. Biotechnol., 11.","DOI":"10.1186\/s40104-020-00460-3"},{"key":"ref_24","unstructured":"Council, N. (1994). Nutrient Requirements of Poultry, National Academy of Sciences. [9th revised ed.]."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1111\/jpn.13657","article-title":"Dietary resveratrol alleviated lipopolysaccharide-induced ileitis through Nrf2 and NF-\u03baB signalling pathways in ducks (Anas platyrhynchos)","volume":"106","author":"Yang","year":"2022","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Jin, S., Yang, H., Jiao, Y., Pang, Q., Wang, Y., Wang, M., Shan, A., and Feng, X. (2021). Dietary curcumin alleviated acute ileum damage of ducks (Anas platyrhynchos) induced by AFB1 through regulating Nrf2-ARE and NF-\u03baB signaling pathways. Foods, 10.","DOI":"10.3390\/foods10061370"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jff.2014.10.018","article-title":"Pterostilbene surpassed resveratrol for anti-inflammatory application: Potency consideration and pharmacokinetics perspective","volume":"11","author":"Choo","year":"2014","journal-title":"J. Funct. Foods"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zhang, L., Zhang, L.L., Zhan, X.A., Zeng, X.F., Zhou, L., Cao, G.T., Chen, A.G., and Yang, C.M. (2016). Effects of dietary supplementation of probiotic, Clostridium butyricum, on growth performance, immune response, intestinal barrier function, and digestive enzyme activity in broiler chickens challenged with Escherichia coli K88. J. Anim. Sci. Biotechnol., 7.","DOI":"10.1186\/s40104-016-0061-4"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10557-018-6780-3","article-title":"Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK\/Nrf2\/HO-1 Pathway in Fructose-Fed Diabetic Rats","volume":"32","author":"Kosuru","year":"2018","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1016\/j.neurobiolaging.2011.08.015","article-title":"Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer\u2019s disease","volume":"33","author":"Chang","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Zhang, L., Zhang, J., Zang, H., Yin, Z., Guan, P., Yu, C., Shan, A., and Feng, X. (2024). Dietary pterostilbene exerts potential protective effects by regulating lipid metabolism and enhancing antioxidant capacity on liver in broilers. J. Anim. Physiol. Anim. Nutr., early view.","DOI":"10.1111\/jpn.13941"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3382\/ps.2013-03423","article-title":"Resveratrol induces antioxidant and heat shock protein mRNA expression in response to heat stress in black-boned chickens","volume":"93","author":"Liu","year":"2014","journal-title":"Poult. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhou, Y., Sun, G., Li, K., Li, Z., Su, A., Liu, X., Li, G., Jiang, R., and Han, R. (2018). Transcriptome profile in bursa of Fabricius reveals potential mode for stress-influenced immune function in chicken stress model. BMC Genom., 19.","DOI":"10.1186\/s12864-018-5333-2"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1016\/j.psj.2020.05.012","article-title":"Morphological characterization of postembryonic development of blood\u2013spleen barrier in duck","volume":"99","author":"Xu","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1002\/jsfa.9084","article-title":"Protective effects of resveratrol against high ambient temperature-induced spleen dysplasia in broilers through modulating splenic redox status and apoptosis","volume":"98","author":"Zhang","year":"2018","journal-title":"J. Sci. Food Agric."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6378","DOI":"10.3382\/ps\/pez471","article-title":"Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers","volume":"98","author":"He","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.2527\/jas.2008-1167","article-title":"Citrulline and intestinal fatty acid-binding protein: Longitudinal markers of postweaning small intestinal function in pigs?","volume":"86","author":"Berkeveld","year":"2008","journal-title":"J. Anim. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.3748\/wjg.v17.i17.2161","article-title":"Wound healing of intestinal epithelial cells","volume":"17","author":"Iizuka","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/1040841X.2011.615298","article-title":"A tolerogenic mucosal immune response leads to persistent Campylobacter jejuni colonization in the chicken gut","volume":"38","author":"Hermans","year":"2012","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5952707","DOI":"10.1155\/2018\/5952707","article-title":"Effect of Resveratrol Dry Suspension on Immune Function of Piglets","volume":"2018","author":"Fu","year":"2018","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3382\/ps.2010-00889","article-title":"Effects of dietary polyphenol-rich grape products on intestinal microflora and gut morphology in broiler chicks","volume":"90","author":"Viveros","year":"2011","journal-title":"Poult. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.intimp.2016.01.028","article-title":"The enhancement of immune function and activation of NF-\u03baB by resveratrol-treatment in immunosuppressive mice","volume":"33","author":"Lai","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jim.2004.12.018","article-title":"Complexes between C1q and C3 or C4: Novel and specific markers for classical complement pathway activation","volume":"298","author":"Wouters","year":"2005","journal-title":"J. Immunol. Methods"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/clinids\/19.5.996-a","article-title":"Fundamental Immunology Edited by William E. Paul. 3rd edition. New York: Raven Press, 1993. 1,490 pp. illustrated. $95","volume":"19","author":"Pasternack","year":"1994","journal-title":"Clin. Infect. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1006\/niox.2001.0367","article-title":"Antioxidant enzymes suppress nitric oxide production through the inhibition of NF-kappa B activation: Role of H2O2 and nitric oxide in inducible nitric oxide synthase expression in macrophages","volume":"5","author":"Han","year":"2001","journal-title":"Nitric Oxide"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni1001-907","article-title":"Nitric oxide and the immune response","volume":"2","author":"Bogdan","year":"2001","journal-title":"Nat. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1089-8603(03)00032-6","article-title":"Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-kappaB-mediated iNOS protein expression","volume":"8","author":"Aktan","year":"2003","journal-title":"Nitric Oxide"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1096\/fj.01-0240hyp","article-title":"Cysteine-Zn2+ complexes: Unique molecular switches for inducible nitric oxide synthase-derived NO","volume":"15","author":"Kroncke","year":"2001","journal-title":"FASEB J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0006-2952(01)00775-4","article-title":"Immunomodulatory activity of resveratrol: Suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production","volume":"62","author":"Gao","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2478\/v10004-007-0020-8","article-title":"Evaluation of resveratrol and piceatannol cytotoxicity in macrophages, T cells, and skin cells","volume":"58","author":"Radkar","year":"2007","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/excr.1999.4471","article-title":"Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines","volume":"249","author":"Hsieh","year":"1999","journal-title":"Exp. Cell Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0304-3835(00)00511-5","article-title":"Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells","volume":"158","author":"Schneider","year":"2000","journal-title":"Cancer Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0377-8401(03)00163-9","article-title":"A review of interactions between dietary fibre and the intestinal mucosa, and their consequences on digestive health in young non-ruminant animals","volume":"108","author":"Montagne","year":"2003","journal-title":"Anim. Feed Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1039\/C5FO01338K","article-title":"Resveratrol modulates intestinal morphology and HSP70\/90, NF-\u03baB and EGF expression in the jejunal mucosa of black-boned chickens on exposure to circular heat stress","volume":"7","author":"Liu","year":"2016","journal-title":"Food Funct."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"skz373","DOI":"10.1093\/jas\/skz373","article-title":"Dietary pterostilbene supplementation attenuates intestinal damage and immunological stress of broiler chickens challenged with lipopolysaccharide","volume":"98","author":"Zhang","year":"2020","journal-title":"J. Anim. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.3382\/ps\/pex266","article-title":"Resveratrol alleviates heat stress-induced impairment of intestinal morphology, microflora, and barrier integrity in broilers","volume":"96","author":"Zhang","year":"2017","journal-title":"Poult. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.intimp.2018.09.009","article-title":"Polydatin ameliorates dextran sulfate sodium-induced colitis by decreasing oxidative stress and apoptosis partially via Sonic hedgehog signaling pathway","volume":"64","author":"Lv","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1080\/14728222.2016.1177023","article-title":"Polydatin ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3 activation-mediated mitochondrial protection","volume":"20","author":"Zeng","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Bereswill, S., Mu\u00f1oz, M., Fischer, A., Plickert, R., Haag, L.-M., Otto, B., K\u00fchl, A.A., Loddenkemper, C., G\u00f6bel, U.B., and Heimesaat, M.M. (2010). Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015099"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1021\/acs.chemrestox.6b00001","article-title":"Protective capacity of resveratrol, a natural polyphenolic compound, against deoxynivalenol-induced intestinal barrier dysfunction and bacterial translocation","volume":"29","author":"Ling","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/mi.2014.35","article-title":"Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut","volume":"7","author":"Caruso","year":"2014","journal-title":"Mucosal Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1053\/j.gastro.2017.05.022","article-title":"Intestinal epithelial sirtuin 1 regulates intestinal inflammation during aging in mice by altering the intestinal microbiota","volume":"153","author":"Wellman","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1124\/jpet.109.160838","article-title":"Resveratrol (trans-3, 5, 4\u2032-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-\u03baB activation to abrogate dextran sulfate sodium-induced colitis","volume":"332","author":"Singh","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/13\/1851\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:02:55Z","timestamp":1760108575000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/13\/1851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,22]]},"references-count":63,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ani14131851"],"URL":"https:\/\/doi.org\/10.3390\/ani14131851","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,22]]}}}