{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:57:51Z","timestamp":1780527471353,"version":"3.54.1"},"reference-count":32,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","award":["MCIN\/AEI\/10.13039\/50110 0 011033\/FEDER"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/50110 0 011033\/FEDER"]}]},{"name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","award":["PID2022-141906OB-C22"],"award-info":[{"award-number":["PID2022-141906OB-C22"]}]},{"name":"Consejer\u00eda de Medio Rural y Pol\u00edtica Agraria from Government of the Principality of Asturias","award":["MCIN\/AEI\/10.13039\/50110 0 011033\/FEDER"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/50110 0 011033\/FEDER"]}]},{"name":"Consejer\u00eda de Medio Rural y Pol\u00edtica Agraria from Government of the Principality of Asturias","award":["PID2022-141906OB-C22"],"award-info":[{"award-number":["PID2022-141906OB-C22"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Reports on neoplasms in bears are scarce, especially concerning ovarian tumors. A large primary ovarian neoplasm with multiple metastasis was found during the necropsy of a 14-year-old free-ranging Eurasian brown bear (Ursus arctos) from Northwestern Spain. Histopathology and immunohistochemistry allowed for the diagnosis of a sex cord stromal tumor. This is a complex group of neoplasms which differ in the predominant cell morphology and immunohistochemical features. The microscopic examination revealed two types of cells, one with eosinophilic cytoplasm, intermingled with larger vacuolated cells rich in lipids. The evaluation of the immunoreactivity to different markers, frequently used in the characterization of gonadal tumors (INHA, inhibin-alpha; PLAP, placental alkaline phosphatase; Ki-67; \u03b1-SMA, actin alpha-smooth muscle) and inflammation patterns (IBA1, ionized calcium-binding adapter molecule for macrophages; CD3 for T lymphocytes; CD20 for B lymphocytes), displayed significant INHA positive immunostaining of neoplastic cells, as well as inflammatory cell infiltration, mainly composed of macrophages and B lymphocytes. These findings were consistent with a malignant ovarian steroid cell tumor, not otherwise specified. The present study characterizes an unusual type of neoplasm, and also represents the first report of an ovarian sex cord stromal tumor in Ursidae.<\/jats:p>","DOI":"10.3390\/ani14131936","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T04:53:27Z","timestamp":1719809607000},"page":"1936","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ovarian Sex Cord Stromal Tumor in a Free-Ranging Brown Bear (Ursus arctos)"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5027-3072","authenticated-orcid":false,"given":"Natalia","family":"Garc\u00eda-\u00c1lvarez","sequence":"first","affiliation":[{"name":"Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4080-3057","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Oleaga","sequence":"additional","affiliation":[{"name":"Sociedad de Servicios del Principado de Asturias S.A. (SERPA), La Laboral, 33203 Gij\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-6561","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Garc\u00eda-Iglesias","sequence":"additional","affiliation":[{"name":"Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8060-6368","authenticated-orcid":false,"given":"Claudia","family":"P\u00e9rez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Sociedad de Servicios del Principado de Asturias S.A. (SERPA), La Laboral, 33203 Gij\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Miguel","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n General de Planificaci\u00f3n Agraria del Principado de Asturias, 33007 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Balsera","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n General de Planificaci\u00f3n Agraria del Principado de Asturias, 33007 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5121-7264","authenticated-orcid":false,"given":"Ana","family":"Balseiro","sequence":"additional","affiliation":[{"name":"Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"},{"name":"Departamento de Sanidad Animal, Instituto de Ganader\u00eda de Monta\u00f1a (CSIC-ULE), Finca Marzanas, Grulleros, 24346 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.7589\/JWD-D-20-00014","article-title":"Peritoneal Mesothelioma in a Free-Ranging American Black Bear (Ursus Americanus)","volume":"57","author":"Kelly","year":"2021","journal-title":"J. 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