{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:15:28Z","timestamp":1760145328799,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Veterinary Medicine Hannover, Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>An adult, 362 g, male, intact inland bearded dragon (Pogona vitticeps) was admitted to a veterinary clinic due to a temporary cloacal prolapse and a two-week history of reduced overall condition and forage intake. Physical examination revealed an approximately 2 \u00d7 1 cm round-shaped, rigid intracoelomic tissue mass. Multiple sand deposits were present on the cloacal mucous membranes, though no signs of cloacal prolapse were present. The lizard was otherwise responsive but showed reduced body tension and movement behavior. Initial fecal examination revealed a high-grade oxyuriasis. A 2 \u00d7 1.5 cm sized intracoelomic, well-vascularized, round-shaped mass was subsequently visualized by ultrasonography. After a two-day stabilization therapy, the intracoelomic mass was removed by performing a standard ventral coeliotomy under general anesthesia. Histopathological examination of the excised mass revealed an acinar pancreatic adenocarcinoma with infiltration of the peritumorous connective soft tissue. The lizard remained at the clinic for a further seven days. Its postsurgical condition improved slowly. However, the lizard started regular forage intake 10 days after surgery, and general behavior enhanced constantly within the following three weeks. The animal was presented for a follow-up six weeks after surgery, showing bright and alert behavior with no signs of disease or illness. The lizard was re-examined 20 months after the initial presentation due to a reduced overall condition and reduced food intake. Blood chemistry evaluation revealed markedly decreased protein parameters, and moderate ascites was identified ultrasonographically. A distinct association with the preceding neoplastic disease could not be made, and the lizard returned to its regular condition under supportive therapy within three weeks. To the authors\u2019 knowledge, this is the first report of successful treatment of a pancreatic carcinoma in a bearded dragon.<\/jats:p>","DOI":"10.3390\/ani14131976","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T03:52:58Z","timestamp":1720065178000},"page":"1976","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Treatment of an Acinar Pancreatic Carcinoma in an Inland Bearded Dragon (Pogona vitticeps): A Case Report"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8997-5944","authenticated-orcid":false,"given":"Johannes","family":"Hetterich","sequence":"first","affiliation":[{"name":"Department of Small Mammal, Reptile and Avian Medicine and Surgery, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Hewicker-Trautwein","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8223-7233","authenticated-orcid":false,"given":"Wencke","family":"Reineking","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8822-4409","authenticated-orcid":false,"given":"Lisa","family":"Allnoch","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7244-9697","authenticated-orcid":false,"given":"Michael","family":"Pees","sequence":"additional","affiliation":[{"name":"Department of Small Mammal, Reptile and Avian Medicine and Surgery, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"unstructured":"Divers, S.J., and Stahl, S.J. (2018). Mader\u2019s Reptile and Amphibian Medicine and Surgery-e-Book, Elsevier Health Sciences.","key":"ref_1"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1094-9194(02)00054-3","article-title":"Diseases of the reptile pancreas","volume":"6","author":"Stahl","year":"2003","journal-title":"Vet Clin. N. Am. Exot. Anim. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1638\/2016-0131.1","article-title":"Multihormonal islet cell carcinomas in three komodo dragons (Varanus komodoensis)","volume":"48","author":"Eustace","year":"2017","journal-title":"J. Zoo Wildl. Med."},{"unstructured":"Frye, F.L., McNeely, H.E., and Corcoran, J.H. (1999, January 5\u20139). Functional pancreatic glucagonoma in the rhinoceros iguana Cyclura c. figgensi, characterized by immunocytochemistry. 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Hung."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jcpa.2021.05.004","article-title":"Pathology of the Bearded Dragon (Pogona vitticeps): A Retrospective Analysis of 36 Cases","volume":"186","author":"Crouch","year":"2021","journal-title":"J. Comp. 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