{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:18:02Z","timestamp":1789690682135,"version":"4.0.1"},"reference-count":36,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:00:00Z","timestamp":1720828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Colciencias-Colombian government","award":["FP44842-131-2017"],"award-info":[{"award-number":["FP44842-131-2017"]}]},{"name":"Universidad Cooperativa de Colombia","award":["FP44842-131-2017"],"award-info":[{"award-number":["FP44842-131-2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The aim of this work was to develop a liver tissue function index during the transition period of dairy cows managed in low-tropic conditions. In two farms, twenty crossbred and synthetic native cows during the peripartum period were selected, and blood samples were taken on days \u221230 and \u221215 prepartum, the calving day, and 7, 20, 35, 50, 65, 80 and 105 days postpartum for serum metabolic tests. On each measurement day, body condition scores (BCS) and parameters on nitrogen metabolism (total protein\u2014TP, albumin\u2014ALB, globulin\u2014GLOB, urea), adipose tissue metabolism (cholesterol\u2014COL, non-esterified fatty acids\u2014NEFA) and two transaminases (alanine aminotransferase\u2014ALT and aspartate aminotransferase\u2014AST) were evaluated. Data analysis included the Spearman correlation, principal components, multiple linear regression and cluster analysis. Results showed that regarding the days after calving and BCS, a liver tissue function index can be constructed using the TP, urea, COL, ALT and NEFA. The estimated index generated three groupings, both by days after calving and BCS. In the former, the index discriminated the metabolic behavior in the prepartum, parturition and postpartum periods, while in the latter, the index discriminated between extreme (2.25, 2.50 and 4.25), slightly low (2.75 and 3.0) and slightly high (3.25 to 4) conditions. The results allow us to conclude that it is feasible to construct mathematical function indexes for liver function to monitor metabolic changes during highly demanding productive phases in dairy cows under tropical conditions.<\/jats:p>","DOI":"10.3390\/ani14142056","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T08:35:17Z","timestamp":1721032517000},"page":"2056","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Index Development to Comprehensive Assess Liver Function during the Dairy Cows\u2019 Transition Period in Low-Tropic Conditions"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8626-4888","authenticated-orcid":false,"given":"R\u00f3mulo","family":"Campos-Gaona","sequence":"first","affiliation":[{"name":"Facultad de Ciencias Agropecuarias, Universidad Nacional de Colombia, Sede Palmira, Palmira 763531, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Correa-Orozco","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Agropecuarias, Universidad Nacional de Colombia, Sede Palmira, Palmira 763531, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5416-5906","authenticated-orcid":false,"given":"Arcesio","family":"Salamanca-Carre\u00f1o","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Veterinaria y Zootecnia, Universidad Cooperativa de Colombia, Villavicencio 500001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"V\u00e9lez-Terranova","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Agropecuarias, Universidad Nacional de Colombia, Sede Palmira, Palmira 763531, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.3168\/jds.2019-18119","article-title":"ADSA Foundation Scholar Award: Influencing hepatic metabolism: Can nutrient partitioning be modulated to optimize metabolic health in the transition dairy cow?","volume":"103","author":"White","year":"2020","journal-title":"J. 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