{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:14:28Z","timestamp":1789564468901,"version":"build-2803163510"},"reference-count":97,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Similar to humans, dogs could suffer an Attention-Deficit\/Hyperactivity Disorder-like syndrome (ADHD-like). In fact, several studies highlight the use of dogs as a model for studying ADHD. This condition entails behavioral problems expressed through impulsivity, attention issues, hyperactivity, and\/or aggression, compromising the quality of life for both the caregiver and the dog. The pathophysiology of ADHD-like is complex and is associated with dysregulation of various neurotransmitters such as serotonin and dopamine. The expression of ADHD-like behavior in dogs would appear to depend on a classical gene\u2013environment interaction as is the case with many neurological disorders in humans. In addition to the described symptomatology, ADHD-like dogs can exhibit strong comorbidities with compulsive behaviors, aggressiveness, inappropriate elimination and fearfulness, in addition to epilepsy, foreign body ingestion, and pruritus. In spite of the fact that there is no veterinary consensus about the diagnosis of ADHD-like, some validated questionnaires could be helpful, but these cannot be used as a unique diagnostic tool. The use of drugs, such as fluoxetine, in addition to an adequate environmental enrichment, relaxation protocols, and behavior modification can achieve an adequate quality of life for both the dog and caregivers.<\/jats:p>","DOI":"10.3390\/ani14142067","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T08:35:17Z","timestamp":1721032517000},"page":"2067","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["New Advances in Attention-Deficit\/Hyperactivity Disorder-like Dogs"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8360-1879","authenticated-orcid":false,"given":"\u00c1ngela","family":"Gonz\u00e1lez-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Veterinary Teaching Hospital Rof Codina, Santiago de Compostela University, 27002 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Mu\u00f1iz de Miguel","sequence":"additional","affiliation":[{"name":"Anatomy, Animal Production and Clinical Veterinary Sciences Departament, Santiago de Compostela University, 27002 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3642-481X","authenticated-orcid":false,"given":"Francisco","family":"Di\u00e9guez","sequence":"additional","affiliation":[{"name":"Anatomy, Animal Production and Clinical Veterinary Sciences Departament, Santiago de Compostela University, 27002 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,14]]},"reference":[{"key":"ref_1","first-page":"368","article-title":"Hyperkinesis in Dogs: Six Case Reports","volume":"34","author":"Luescher","year":"1993","journal-title":"Can. Vet. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jveb.2021.03.007","article-title":"Effect of Fluoxetine at a Dosage of 2\u20134 mg\/kg Daily in Dogs Exhibiting Hypersensitivity-Hyperactivity Syndrome, a Retrospective Study","volume":"44","author":"Muller","year":"2021","journal-title":"J. Vet. Behav."},{"key":"ref_3","first-page":"1","article-title":"Assessment of a Canine Hypersensitivity-Hyperactivity Syndrome Rating Scale","volume":"8","author":"Marlois","year":"2022","journal-title":"Dog Behav."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.17140\/VMOJ-2-122","article-title":"Correlates of Attention Deficit Hyperactivity Disorder (ADHD)-Like Behavior in Domestic Dogs: First Results from a Questionnaire-Based Study","volume":"2","author":"Hoppe","year":"2017","journal-title":"Vet. Med. Open J."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Bleuer-Elsner, S., Zamansky, A., Fux, A., Kaplun, D., Romanov, S., Sinitca, A., Masson, S., and van der Linden, D. (2019). Computational Analysis of Movement Patterns of Dogs with ADHD-like Behavior. Animals, 9.","DOI":"10.3390\/ani9121140"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41398-021-01626-x","article-title":"Canine Hyperactivity, Impulsivity, and Inattention Share Similar Demographic Risk Factors and Behavioural Comorbidities with Human ADHD","volume":"11","author":"Sulkama","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.applanim.2006.03.017","article-title":"Measuring Attention Deficit and Activity in Dogs: A New Application and Validation of a Human ADHD Questionnaire","volume":"103","author":"Vas","year":"2007","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1744-9081-6-1","article-title":"Owner Reports of Attention, Activity, and Impulsivity in Dogs: A Replication Study","volume":"6","author":"Lit","year":"2010","journal-title":"Behav. Brain Funct."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Mart\u00ednez, \u00c1., Mu\u00f1iz de Miguel, S., Gra\u00f1a, N., Costas, X., and Di\u00e9guez, F.J. (2023). Serotonin and Dopamine Blood Levels in ADHD-Like Dogs. Animals, 13.","DOI":"10.3390\/ani13061037"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.beproc.2018.03.012","article-title":"Impulsivity and Behaviour Problems in Dogs: A Reinforcement Sensitivity Theory Perspective","volume":"151","author":"Piotti","year":"2018","journal-title":"Behav. Process."},{"key":"ref_11","first-page":"11","article-title":"A One Health Approach to Neurodiversity and Attention-Deficit\/Hyperactivity Disorder in People and Dogs: Implications for Research, Treatments, and Acceptance","volume":"73","author":"Tsakiris","year":"2023","journal-title":"J. Am. Holist. Vet. Med. Assoc."},{"key":"ref_12","first-page":"423","article-title":"Biochemical Markers and Genetic Research of ADHD","volume":"26","author":"Paclt","year":"2005","journal-title":"Neuroendocrinol. Lett."},{"key":"ref_13","first-page":"4","article-title":"Comparing the Efficacy of Medications for ADHD Using Meta-Analysis","volume":"8","author":"Faraone","year":"2006","journal-title":"MedGenMed Medscape Gen. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S2215-0366(17)30049-4","article-title":"Subcortical Brain Volume Differences in Participants with Attention Deficit Hyperactivity Disorder in Children and Adults: A Cross-Sectional Mega-Analysis","volume":"4","author":"Hoogman","year":"2017","journal-title":"Artic. Lancet Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Csibra, B., Bunford, N., and G\u00e1csi, M. (2022). Evaluating ADHD Assessment for Dogs: A Replication Study. Animals, 12.","DOI":"10.3390\/ani12070807"},{"key":"ref_16","first-page":"111","article-title":"Methylphenidate Use in Dogs with Attention Deficit Hyperactivity Disorder (ADHD). A Case Report of a Weimaraner Bitch","volume":"42","author":"Piturru","year":"2014","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"key":"ref_17","first-page":"15","article-title":"Retrospective Study on Hypersensitivity-Hyperactivity Syndrome in Dogs: Long-Term Outcome of High Dose Fluoxetine Treatment and Proposal of a Clinical Score","volume":"4","author":"Masson","year":"2018","journal-title":"Dog Behav."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1037\/com0000151","article-title":"Associations among Behavioral Inhibition and Owner-Rated Attention, Hyperactivity\/Impulsivity, and Personality in the Domestic Dog (Canis Familiaris)","volume":"133","author":"Bunford","year":"2019","journal-title":"J. Comp. Psychol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1038\/s41598-022-07443-6","article-title":"Aggressiveness, ADHD-like Behaviour, and Environment Influence Repetitive Behaviour in Dogs","volume":"12","author":"Sulkama","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1038\/s41598-024-51924-9","article-title":"Development of a Human-Analogue, 3-Symptom Domain Dog ADHD and Functionality Rating Scale (DAFRS)","volume":"14","author":"Csibra","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jveb.2019.04.007","article-title":"Demographics and Comorbidity of Behavior Problems in Dogs","volume":"32","author":"Dinwoodie","year":"2019","journal-title":"J. Vet. Behav."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1038\/s41598-020-59837-z","article-title":"Prevalence, Comorbidity, and Breed Differences in Canine Anxiety in 13,700 Finnish Pet Dogs","volume":"10","author":"Salonen","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jveb.2020.06.003","article-title":"Problematic Behaviors in Companion Dogs: A Survey of Their Prevalence and Associated Factors","volume":"39","author":"Didehban","year":"2020","journal-title":"J. Vet. Behav."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.biopsych.2004.09.008","article-title":"Causal Models of Attention-Deficit\/Hyperactivity Disorder: From Common Simple Deficits to Multiple Developmental Pathways","volume":"57","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1001\/jama.288.14.1740","article-title":"Developmental Trajectories of Brain Volume Abnormalities in Children and Adolescents with Attention-Deficit\/Hyperactivity Disorder","volume":"288","author":"Castellanos","year":"2022","journal-title":"JAMA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1001\/jamapsychiatry.2014.3162","article-title":"Developmentally Stable Whole-Brain Volume Reductions and Developmentally Sensitive Caudate and Putamen Volume Alterations in Those with Attention-Deficit\/hyperactivity disorder and their unaffected siblings","volume":"72","author":"Greven","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"19663","DOI":"10.1073\/pnas.0710329105","article-title":"Neuro-Anatomic Evidence for the Maturational Delay Hypothesis of ADHD","volume":"104","author":"Rubia","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/sj.mp.4001244","article-title":"The Serotonin 5-HT1B Receptor Gene and Attention Deficit Hyperactivity Disorder","volume":"8","author":"Quist","year":"2003","journal-title":"Mol. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/00019052-200312002-00002","article-title":"Dopamine: A Key Regulator to Adapt Action, Emotion, Motivation and Cognition","volume":"16","author":"Nieoullon","year":"2003","journal-title":"Curr. Opin. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1001\/jama.2009.1308","article-title":"Evaluating Dopamine Reward Pathway in ADHD: Clinical Implications","volume":"302","author":"Volkow","year":"2009","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e6838","DOI":"10.7717\/peerj.6838","article-title":"Dominance in Dogs as Rated by Owners Corresponds to Ethologically Valid Markers of Dominance","volume":"2019","author":"Kubinyi","year":"2019","journal-title":"PeerJ"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kubinyi, E., Vas, J., Hejjas, K., Ronai, Z., Br\u00fader, I., Turcs\u00e1n, B., Sasvari-Szekely, M., and Mikl\u00f3si, \u00c1. (2012). Polymorphism in the Tyrosine Hydroxylase (TH) Gene Is Associated with Activity-Impulsivity in German Shepherd Dogs. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030271"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1292\/jvms.66.815","article-title":"Allele Frequency Distribution of the Canine Dopamine Receptor D4 Gene Exon III and I in 23 Breeds","volume":"66","author":"Ito","year":"2004","journal-title":"J. Vet. Med. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00335-007-9070-0","article-title":"Novel Repeat Polymorphisms of the Dopaminergic Neurotransmitter Genes among Dogs and Wolves","volume":"18","author":"Hejjas","year":"2007","journal-title":"Mamm. Genome"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1601-183X.2008.00475.x","article-title":"Molecular and Behavioral Analysis of the Intron 2 Repeat Polymorphism in the Canine Dopamine D4 Receptor Gene","volume":"8","author":"Hejjas","year":"2009","journal-title":"Genes Brain Behav."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neuint.2015.02.001","article-title":"Does Serotonin Deficit Mediate Susceptibility to ADHD?","volume":"82","author":"Banerjee","year":"2015","journal-title":"Neurochem. Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00702-014-1180-8","article-title":"Glutamate as a Neurotransmitter in the Healthy Brain","volume":"121","author":"Zhou","year":"2014","journal-title":"J. Neural Transm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.tvjl.2009.07.029","article-title":"Serotonin Transporter Activity in Platelets and Canine Aggression","volume":"186","author":"Rosado","year":"2010","journal-title":"Vet. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jveb.2012.01.005","article-title":"Assessment of Serotonin in Serum, Plasma, and Platelets of Aggressive Dogs","volume":"7","author":"Rosado","year":"2012","journal-title":"J. Vet. Behav. Clin. Appl. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.applanim.2010.01.009","article-title":"Blood Concentrations of Serotonin, Cortisol and Dehydroepiandrosterone in Aggressive Dogs","volume":"123","author":"Rosado","year":"2010","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jveb.2012.04.003","article-title":"Differences in Serotonin Serum Concentration between Aggressive English Cocker Spaniels and Aggressive Dogs of Other Breeds","volume":"8","author":"Amat","year":"2013","journal-title":"J. Vet. Behav. Clin. Appl. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.physbeh.2011.09.019","article-title":"Behavioural and Physiological Correlates of Impulsivity in the Domestic Dog (Canis Familiaris)","volume":"105","author":"Wright","year":"2012","journal-title":"Physiol. Behav."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e145","DOI":"10.1016\/j.biopsych.2011.02.036","article-title":"The Roles of Dopamine and Noradrenaline in the Pathophysiology and Treatment of Attention-Deficit\/Hyperactivity Disorder","volume":"69","author":"Chamberlain","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/ng.1013","article-title":"Genome-Wide Copy Number Variation Study Associates Metabotropic Glutamate Receptor Gene Networks with Attention Deficit Hyperactivity Disorder","volume":"44","author":"Elia","year":"2012","journal-title":"Nat. Genet."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e999","DOI":"10.1038\/tp.2016.273","article-title":"Glutamatergic and GABAergic Gene Sets in Attention-Deficit\/Hyperactivity Disorder: Association to Overlapping Traits in ADHD and Autism","volume":"7","author":"Naaijen","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0301-0082(00)00039-3","article-title":"The Physiology of Brain Histamine","volume":"63","author":"Brown","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Miyazaki, C., Koyama, M., Ota, E., Swa, T., Mlunde, L.B., Amiya, R.M., Tachibana, Y., Yamamoto-Hanada, K., and Mori, R. (2017). Allergic Diseases in Children with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis. BMC Psychiatry, 17.","DOI":"10.1186\/s12888-017-1281-7"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/mp.2010.97","article-title":"Motivation Deficit in ADHD Is Associated with Dysfunction of the Dopamine Reward Pathway","volume":"16","author":"Volkow","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1086\/381561","article-title":"Joint Analysis of the DRD5 Marker Concludes Association with Attention-Deficit\/Hyperactivity Disorder Confined to the Predominantly Inattentive and Combined Subtypes","volume":"74","author":"Lowe","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1365-2052.2007.01657.x","article-title":"Association of Polymorphisms in the Dopamine D4 Receptor Gene and the Activity-Impulsivity Endophenotype in Dogs","volume":"38","author":"Hejjas","year":"2007","journal-title":"Anim. Genet."},{"key":"ref_51","first-page":"77","article-title":"Association of the Dopamine Beta Hydroxylase Gene with Attention Deficit Hyperactivity Disorder: Genetic Analysis of the Milwaukee Longitudinal Study","volume":"119","author":"Daly","year":"2003","journal-title":"Am. J. Med. Genet."},{"key":"ref_52","first-page":"32","article-title":"Hyperactivity in a Weimaraner Dog","volume":"1","author":"Rosado","year":"2015","journal-title":"Dog Behav."},{"key":"ref_53","unstructured":"(2022). Physiology of Behavior, Pearson Education."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/13651500701388310","article-title":"The Importance of Serotonin and Noradrenaline in Anxiety","volume":"11","author":"Blier","year":"2007","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Stahl, S.M. (2021). Stahl\u2019s Essential Psychopharmacology, Cambridge University Press. [5th ed.].","DOI":"10.1017\/9781108975292"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neubiorev.2016.11.002","article-title":"Clock Genes, ADHD and Aggression","volume":"91","author":"Mogavero","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0022-3476(71)80428-6","article-title":"Serotonin Concentrations in Whole Blood of Hyperactive Children","volume":"78","author":"Coleman","year":"1971","journal-title":"J. Pediatr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1600-0447.1999.tb07229.x","article-title":"Circulatory Levels of Catecholamines, Serotonin and Lipids in Attention Deficit Hyperactivity Disorder","volume":"99","author":"Spivak","year":"1999","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00004583-200102000-00022","article-title":"Genetics of Childhood Disorders: XXIII. ADHD, Part 7: The Serotonin System","volume":"40","author":"Lombroso","year":"2001","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1037\/0033-2909.121.1.65","article-title":"Behavioral Inhibition, Sustained Attention, and Executive Functions: Constructing a Unifying Theory of ADHD","volume":"121","author":"Barkley","year":"1997","journal-title":"Psychol. Bull."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.pbb.2011.01.020","article-title":"Catecholamine Influences on Prefrontal Cortical Function: Relevance to Treatment of Attention Deficit Hyperactivity Disorder and Related Disorders","volume":"99","author":"Arnsten","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_62","unstructured":"Rohde, L.A., Buitelaar, J.K., Gerlach, M., and Faraone, S.V. (2019). La Federaci\u00f3n Mundial de Gu\u00eda TDAH, Sociedad Espa\u00f1ola de Medicina de la Adolescencia (SEMA)."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Sanders, A.R., Bhongir, N., vonHoldt, B., and Pellegrini, M. (2022). Association of DNA Methylation with Energy and Fear-Related Behaviors in Canines. Front. Psychol., 13.","DOI":"10.3389\/fpsyg.2022.1025494"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jveb.2016.03.004","article-title":"Social Rearing Environment Influences Dog Behavioral Development","volume":"16","author":"Harvey","year":"2016","journal-title":"J. Vet. Behav. Clin. Appl. Res."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Lindsay, S. (2001). Handbook of Applied Dog Behavior and Training, Vol 2: Etiology and Assessment of Behavior Problems, Iowa State University Press.","DOI":"10.1002\/9780470376997"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0003-3472(67)90024-3","article-title":"The Effects of Early Experience on the Development of Inter and Intraspecies Social Relationships in the Dog","volume":"15","author":"Fox","year":"1967","journal-title":"Anim. Behav."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1749-6632.1969.tb12974.x","article-title":"The Role of Early Experience in Emotional Arousal","volume":"159","author":"Melzack","year":"1969","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_68","unstructured":"Morrison, J. (2015). DSM-5\u00ae Gu\u00eda Para El Diagn\u00f3stico Cl\u00ednico, Manual Moderno."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"15020","DOI":"10.1038\/nrdp.2015.20","article-title":"Attention-Deficit\/Hyperactivity Disorder","volume":"1","author":"Faraone","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"210","DOI":"10.46867\/IJCP.2011.24.02.03","article-title":"Development and Validation of a Psychometric Tool for Assessing Impulsivity in the Domestic Dog (Canis Familiaris)","volume":"24","author":"Wright","year":"2011","journal-title":"Int. J. Comp. Psychol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2460\/javma.244.3.309","article-title":"Evaluation of the Risk and Age of Onset of Cancer and Behavioral Disorders in Gonadectomized Vizslas","volume":"244","author":"Zink","year":"2014","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"22162","DOI":"10.1038\/srep22162","article-title":"Differences in Trait Impulsivity Indicate Diversification of Dog Breeds into Working and Show Lines","volume":"6","author":"Fadel","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"22","DOI":"10.17140\/VMOJ-2-113","article-title":"The Social Behaviour of Neutered Male Dogs Compared to Intact Dogs (Canis Lupus Familiaris): Video Analyses, Questionnaires and Case Studies","volume":"2","author":"Kaufmann","year":"2017","journal-title":"Vet. Med. Open J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/s41598-023-28263-2","article-title":"Owner\u2014Rated Hyperactivity\/Impulsivity Is Associated with Sleep Efficiency in Family Dogs: A Non - Invasive EEG Study","volume":"13","author":"Carreiro","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_75","unstructured":"Landsberg, G., and Radosta, L.A.L. (2024). Behavior Problems of the Dog and Cat, Elsevier Inc.. [4th ed.]."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1176\/ajp.150.12.1792","article-title":"Patterns of Psychiatric Comorbidity, Cognition, and Psychosocial Functioning in Adults with Attention Deficit Hyperactivity Disorder","volume":"150","author":"Biederman","year":"1993","journal-title":"Am. J. Psychiatry"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0165-1781(95)02596-O","article-title":"Attention Deficit Hyperactivity Disorder and Whole-Blood Serotonin Levels: Effects of Comorbidity","volume":"57","author":"Cook","year":"1995","journal-title":"Psychiatry Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00787-014-0577-0","article-title":"Comorbidity of ADHD and Incontinence in Children","volume":"24","author":"Equit","year":"2015","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"106060","DOI":"10.1016\/j.tvjl.2023.106060","article-title":"Epilepsy Is More than a Simple Seizure Disorder: Parallels between Human and Canine Cognitive and Behavioural Comorbidities","volume":"303","author":"Peek","year":"2024","journal-title":"Vet. J."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jveb.2021.04.001","article-title":"Link between Foreign Body Ingestion and Behavioural Disorder in Dogs","volume":"45","author":"Masson","year":"2021","journal-title":"J. Vet. Behav."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Harvey, N., Craigon, P., Shaw, S., Blott, S., and England, G. (2019). Behavioural Differences in Dogs with Atopic Dermatitis Suggest Stress Could Be a Significant Problem Associated with Chronic Pruritus. Animals, 9.","DOI":"10.3390\/ani9100813"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000533366","article-title":"Associations of Atopic Dermatitis with Attention Deficit\/Hyperactivity Disorder and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis","volume":"240","author":"Cheng","year":"2024","journal-title":"Dermatology"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Courtney, A., and Su, J.C. (2024). The Psychology of Atopic Dermatitis. J. Clin. Med., 13.","DOI":"10.3390\/jcm13061602"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12993-016-0091-2","article-title":"Non-Targeted Metabolite Profiling Reveals Changes in Oxidative Stress, Tryptophan and Lipid Metabolisms in Fearful Dogs","volume":"12","author":"Puurunen","year":"2016","journal-title":"Behav. Brain Funct."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s10071-013-0701-4","article-title":"Impulsive for Life? The Nature of Long-Term Impulsivity in Domestic Dogs","volume":"17","author":"Riemer","year":"2014","journal-title":"Anim. Cogn."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Csibra, B., Reicher, V., and Csepregi, M. (2024). Towards an Objective Measurement Tool for ADHD-like Traits in Family Dogs: A Comprehensive Test Battery. Animals, 14.","DOI":"10.3390\/ani14131841"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jveb.2011.03.001","article-title":"Physiological and Behavioral Effects of Dextroamphetamine on Beagle Dogs","volume":"6","author":"Stiles","year":"2011","journal-title":"J. Vet. Behav. Clin. Appl. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"104831","DOI":"10.1016\/j.applanim.2019.104831","article-title":"Carrots versus Sticks: The Relationship between Training Methods and Dog-Owner Attachment","volume":"219","author":"Barrett","year":"2019","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Vieira de Castro, A.C., Fuchs, D., Morello, G.M., Pastur, S., de Sousa, L., and Olsson, I.A.S. (2020). Does Training Method Matter? Evidence for the Negative Impact of Aversive-Based Methods on Companion Dog Welfare. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0225023"},{"key":"ref_90","unstructured":"Horwitz, D.F. (2018). Canine and Feline Behavior, John Wiley and Sons. [2nd ed.]."},{"key":"ref_91","unstructured":"Overall, K. (2013). Manual of Clinical Behavioral Medicine for Dogs and Cats-E-Book, Mosby."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Flint, H.E., Atkinson, M., Lush, J., Hunt, A.B.G., and King, T. (2023). Long-Lasting Chews Elicit Positive Emotional States in Dogs during Short Periods of Social Isolation. Animals, 13.","DOI":"10.3390\/ani13040552"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.euroneuro.2023.03.012","article-title":"Efficacy and Safety of Selegiline across Different Psychiatric Disorders: A Systematic Review and Meta-Analysis of Oral and Transdermal Formulations","volume":"72","author":"Rossano","year":"2023","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/chi.0b013e31815d9af7","article-title":"Clonidine for Attention-Deficit\/Hyperactivity Disorder: I. Efficacy and Tolerability Outcomes","volume":"47","author":"Palumbo","year":"2008","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_95","first-page":"556","article-title":"Reproduced with Permission of the Copyright Owner. Further Reproduction Prohibited without","volume":"130","author":"DiFonzo","year":"1998","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.yebeh.2015.11.014","article-title":"Effects of a Ketogenic Diet on ADHD-like Behavior in Dogs with Idiopathic Epilepsy","volume":"55","author":"Packer","year":"2016","journal-title":"Epilepsy Behav."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jveb.2023.06.004","article-title":"A Retrospective Study on the Clinical Use and Owner Perception of Venlafaxine Efficacy as Part of a Multimodal Treatment for Canine Fear, Anxiety, and Aggression","volume":"64\u201365","author":"Maffeo","year":"2023","journal-title":"J. Vet. Behav."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/14\/2067\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:16:49Z","timestamp":1760109409000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/14\/2067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,14]]},"references-count":97,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ani14142067"],"URL":"https:\/\/doi.org\/10.3390\/ani14142067","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,14]]}}}