{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:15:47Z","timestamp":1793128547912,"version":"4.5.0"},"reference-count":93,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The S\u00e3o Paulo Research Foundation","award":["2021\/05445\u20137"],"award-info":[{"award-number":["2021\/05445\u20137"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The implantation of the embryo into the maternal endometrium is a complex process associated with the evolution of viviparity and placentation in mammals. In this review, we provide an overview of maternal recognition of pregnancy signals and implantation modes in eutherians, focusing on their diverse mechanisms and evolutionary patterns. Different pregnancy recognition signals and implantation modes have evolved in eutherian mammals, reflecting the remarkable diversity of specializations in mammals following the evolution of viviparity. Superficial implantation is the ancestral implantation mode in Eutheria and its major clades. The other modes, secondary, partially, and primary interstitial implantation have each independently evolved multiple times in the evolutionary history of eutherians. Although significant progress has been made in understanding pregnancy recognition signals and implantation modes, there is still much to uncover. Rodents and chiropterans (especially Phyllostomidae) offer valuable opportunities for studying the transitions among implantation modes, but data is still scarce for these diverse orders. Further research should focus on unstudied taxa so we can establish robust patterns of evolutionary changes in pregnancy recognition signaling and implantation modes.<\/jats:p>","DOI":"10.3390\/ani14142077","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T08:48:29Z","timestamp":1721206109000},"page":"2077","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evolutionary Patterns of Maternal Recognition of Pregnancy and Implantation in Eutherian Mammals"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-6827","authenticated-orcid":false,"given":"Henrique Bartolomeu","family":"Braz","sequence":"first","affiliation":[{"name":"Ecology and Evolution Laboratory, Butantan Institute, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5240-6959","authenticated-orcid":false,"given":"Rodrigo da Silva Nunes","family":"Barreto","sequence":"additional","affiliation":[{"name":"Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, S\u00e3o Paulo State University, Jaboticabal 14884-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Norberto da","family":"Silva-J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-270, SP, Brazil"},{"name":"Department of Veterinary Medicine, University of Mar\u00edlia, Mar\u00edlia 17525-902, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca de Oliveira","family":"Horvath-Pereira","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-270, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7848-8558","authenticated-orcid":false,"given":"Thamires Santos da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-270, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica Duarte da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-270, SP, Brazil"},{"name":"Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9657-3978","authenticated-orcid":false,"given":"Francisco","family":"Acu\u00f1a","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata B1900, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-115X","authenticated-orcid":false,"given":"Maria Angelica","family":"Miglino","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Mar\u00edlia, Mar\u00edlia 17525-902, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/jmor.20272","article-title":"Evolution of Vertebrate Viviparity and Specializations for Fetal Nutrition: A Quantitative and Qualitative Analysis","volume":"276","author":"Blackburn","year":"2015","journal-title":"J. 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