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This study aims to investigate the effects of Parabacteroides distasonis (PBd) derived from Ningxiang pigs on growth performance, intestinal apoptosis, oxidative damage, and inflammation in ETEC-challenged weaned piglets. A total of 22 Duroc \u00d7 Landrace \u00d7 Yorkshire (DLY) piglets, 24 days old with similar body weights, were randomly divided into three groups: Control (n = 7), ETEC (n = 7), and PBd + ETEC (n = 8). The results show that, compared to the Control group, ETEC challenge led to decreased growth performance, reduced villus height in the duodenum and jejunum, increased crypt depth in the duodenum, a decreased villus-height-to-crypt-depth ratio, increased expression of apoptosis-related genes (Caspase-8 and Caspase-9), increased expression of oxidative damage-related genes (Nrf2, GSH-PX, mTOR, and Beclin1), increased expression of inflammation-related genes (Myd88, P65, TNF-\u03b1, and IL-6), and reduced the contents of SCFAs in the colonic chyme (acetate, propionate, butyrate, valerate, and total SCFAs). Compared to the ETEC group, the PBd + ETEC group alleviated the reduction in growth performance, mitigated intestinal morphological damage, and reduced the expression of the aforementioned apoptosis, oxidative damage, and inflammation-related genes with the increase in SCFAs. In conclusion, PBd derived from Ningxiang pigs effectively reduces ETEC-induced intestinal damage in weaned piglets, improves intestinal health, and increases the content of SCFAs in the colonic chyme, thereby enhancing growth performance.<\/jats:p>","DOI":"10.3390\/ani14152156","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T14:55:47Z","timestamp":1721832947000},"page":"2156","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ningxiang Pig-Derived Parabacteroides distasonis HNAU0205 Alleviates ETEC-Induced Intestinal Apoptosis, Oxidative Damage, and Inflammation in Piglets"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4673-4368","authenticated-orcid":false,"given":"Zichen","family":"Wu","sequence":"first","affiliation":[{"name":"Hunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China"},{"name":"Yuelushan Laboratory, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China"},{"name":"Yuelushan Laboratory, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9531-0273","authenticated-orcid":false,"given":"Hongkun","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China"},{"name":"Yuelushan Laboratory, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyao","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-1530","authenticated-orcid":false,"given":"Bie","family":"Tan","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China"},{"name":"Yuelushan Laboratory, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China"},{"name":"Yuelushan Laboratory, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tang, X., Xiong, K., Fang, R., and Li, M. (2022). Weaning Stress and Intestinal Health of Piglets: A Review. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1042778"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"612","DOI":"10.2527\/jas.2013-6986","article-title":"Development of an Antioxidant System after Early Weaning in Piglets","volume":"92","author":"Yin","year":"2014","journal-title":"J. Anim. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kim, K., Song, M., Liu, Y., and Ji, P. (2022). Enterotoxigenic Escherichia coli Infection of Weaned Pigs: Intestinal Challenges and Nutritional Intervention to Enhance Disease Resistance. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.885253"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"skaa012","DOI":"10.1093\/jas\/skaa012","article-title":"Ingestion of Organic Acids and Cinnamaldehyde Improves Tissue Homeostasis of Piglets Exposed to Enterotoxic Escherichia coli (ETEC)","volume":"98","author":"Berrios","year":"2020","journal-title":"J. Anim. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e01296-22","DOI":"10.1128\/aem.01296-22","article-title":"Bifidobacterium Animalis Promotes the Growth of Weaning Piglets by Improving Intestinal Development, Enhancing Antioxidant Capacity, and Modulating Gut Microbiota","volume":"88","author":"Pang","year":"2022","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Xiang, Q., Wu, X., Pan, Y., Wang, L., Cui, C., Guo, Y., Zhu, L., Peng, J., and Wei, H. (2020). Early-Life Intervention Using Fecal Microbiota Combined with Probiotics Promotes Gut Microbiota Maturation, Regulates Immune System Development, and Alleviates Weaning Stress in Piglets. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21020503"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Li, W., Xu, B., Wang, L., Sun, Q., Deng, W., Wei, F., Ma, H., Fu, C., Wang, G., and Li, S. (2021). Effects of Clostridium butyricum on Growth Performance, Gut Microbiota and Intestinal Barrier Function of Broilers. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.777456"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1136\/gutjnl-2022-329386","article-title":"Parabacteroides distasonis: An Emerging Probiotic?","volume":"72","author":"Wu","year":"2023","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1136\/gutjnl-2022-327756","article-title":"Gut Commensal Parabacteroides distasonis Alleviates Inflammatory Arthritis","volume":"72","author":"Sun","year":"2023","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.celrep.2018.12.028","article-title":"Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids","volume":"26","author":"Wang","year":"2019","journal-title":"Cell Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1016\/j.cmet.2023.07.011","article-title":"Hyodeoxycholic Acid Alleviates Non-Alcoholic Fatty Liver Disease through Modulating the Gut-Liver Axis","volume":"35","author":"Kuang","year":"2023","journal-title":"Cell Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/s41564-023-01418-7","article-title":"Parabacteroides distasonis Uses Dietary Inulin to Suppress NASH via Its Metabolite Pentadecanoic Acid","volume":"8","author":"Wei","year":"2023","journal-title":"Nat. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1922241","DOI":"10.1080\/19490976.2021.1922241","article-title":"Parabacteroides distasonis: Intriguing Aerotolerant Gut Anaerobe with Emerging Antimicrobial Resistance and Pathogenic and Probiotic Roles in Human Health","volume":"13","author":"Ezeji","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ma, M., Fu, T., Wang, Y., Zhang, A., Gao, P., Shang, Q., and Yu, G. (2022). Polysaccharide from Edible Alga Enteromorpha clathrata Improves Ulcerative Colitis in Association with Increased Abundance of Parabacteroides spp. in the Gut Microbiota of Dextran Sulfate Sodium-Fed Mice. Mar. Drugs, 20.","DOI":"10.3390\/md20120764"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e00078-24","DOI":"10.1128\/mbio.00078-24","article-title":"Akkermansia muciniphila and Parabacteroides distasonis Synergistically Protect from Colitis by Promoting ILC3 in the Gut","volume":"15","author":"Gaifem","year":"2024","journal-title":"mBio"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Cuffaro, B., Assohoun, A.L.W., Boutillier, D., S\u00faken\u00edkov\u00e1, L., Desramaut, J., Boudebbouze, S., Salom\u00e9-Desnoulez, S., Hrd\u00fd, J., Waligora-Dupriet, A.J., and Maguin, E. (2020). In Vitro Characterization of Gut Microbiota-Derived Commensal Strains: Selection of Parabacteroides distasonis Strains Alleviating TNBS-Induced Colitis in Mice. Cells, 9.","DOI":"10.3390\/cells9092104"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"14192","DOI":"10.1021\/acs.jafc.1c05839","article-title":"Protective Effect of l -Theanine against DSS-Induced Colitis by Regulating the Lipid Metabolism and Reducing Inflammation via the NF-\u039aB Signaling Pathway","volume":"69","author":"Zhang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"107584","DOI":"10.1016\/j.intimp.2021.107584","article-title":"Effects of Niacin on Intestinal Immunity, Microbial Community and Intestinal Barrier in Weaned Piglets during Starvation","volume":"95","author":"Feng","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Li, H., Ma, L., Li, Z., Yin, J., Tan, B., Chen, J., Jiang, Q., and Ma, X. (2021). Evolution of the Gut Microbiota and Its Fermentation Characteristics of Ningxiang Pigs at the Young Stage. Animals, 11.","DOI":"10.3390\/ani11030638"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Canibe, N., H\u00f8jberg, O., Kongsted, H., Vodolazska, D., Lauridsen, C., Nielsen, T.S., and Sch\u00f6nherz, A.A. (2022). Review on Preventive Measures to Reduce Post-Weaning Diarrhoea in Piglets. Animals, 12.","DOI":"10.3390\/ani12192585"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"16140","DOI":"10.1038\/s41598-019-52530-w","article-title":"Feed Intake of the Sow and Playful Creep Feeding of Piglets Influence Piglet Behaviour and Performance before and after Weaning","volume":"9","author":"Middelkoop","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Blavi, L., Sol\u00e0-Oriol, D., Llonch, P., L\u00f3pez-Verg\u00e9, S., Mart\u00edn-Or\u00fae, S.M., and P\u00e9rez, J.F. (2021). Management and Feeding Strategies in Early Life to Increase Piglet Performance and Welfare around Weaning: A Review. Animals, 11.","DOI":"10.3390\/ani11020302"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.aninu.2020.11.004","article-title":"The Impact of Probiotics on Gut Health via Alternation of Immune Status of Monogastric Animals","volume":"7","author":"Ding","year":"2021","journal-title":"Anim. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.aninu.2017.06.007","article-title":"Using Probiotics to Improve Swine Gut Health and Nutrient Utilization","volume":"3","author":"Liao","year":"2017","journal-title":"Anim. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejphar.2015.03.002","article-title":"Magnolol and Honokiol Regulate the Calcium-Activated Potassium Channels Signaling Pathway in Enterotoxigenic Escherichia coli-Induced Diarrhea Mice","volume":"755","author":"Deng","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Xu, J., Jia, Z., Xiao, S., Long, C., and Wang, L. (2023). Effects of Enterotoxigenic Escherichia coli Challenge on Jejunal Morphology and Microbial Community Profiles in Weaned Crossbred Piglets. Microorganisms, 11.","DOI":"10.3390\/microorganisms11112646"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"25640","DOI":"10.1038\/srep25640","article-title":"Proteome Analysis for the Global Proteins in the Jejunum Tissues of Enterotoxigenic Escherichia coli-Infected Piglets","volume":"6","author":"Ren","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_28","first-page":"3461768","article-title":"Effect of Probiotics and Herbal Products on Intestinal Histomorphological and Immunological Development in Piglets","volume":"2020","author":"Ansonska","year":"2020","journal-title":"Vet. Med. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s42269-021-00522-0","article-title":"Probiotics Role of Saccharomyces cerevisiae and Bacillus subtilis in Improving the Health Status of Rabbits\u2019 Gastrointestinal Tract","volume":"45","author":"Helal","year":"2021","journal-title":"Bull. Natl. Res. Cent."},{"key":"ref_30","first-page":"91","article-title":"Effect of Probiotic Supplementation on Nutrients Digestibility and Intestinal Histomorphology of Growing Rabbits","volume":"14","author":"Maklad","year":"2023","journal-title":"J. Anim. Poult. Prod."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jnutbio.2013.12.006","article-title":"Dietary Supplementation of Aspartate Enhances Intestinal Integrity and Energy Status in Weanling Piglets after Lipopolysaccharide Challenge","volume":"25","author":"Pi","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wu, T., Shi, Y., Zhang, Y., Zhang, M., Zhang, L., Ma, Z., Zhao, D., Wang, L., Yu, H., and Hou, Y. (2021). Lactobacillus rhamnosus LB1 Alleviates Enterotoxigenic Escherichia coli-Induced Adverse Effects in Piglets by Improving Host Immune Response and Anti-Oxidation Stress and Restoring Intestinal Integrity. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.724401"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.2147\/JIR.S318327","article-title":"Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity","volume":"14","author":"Yang","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Qian, S., Wei, Z., Yang, W., Huang, J., Yang, Y., and Wang, J. (2022). The Role of BCL-2 Family Proteins in Regulating Apoptosis and Cancer Therapy. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.985363"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1007\/s12035-023-03433-5","article-title":"A Review on Caspases: Key Regulators of Biological Activities and Apoptosis","volume":"60","author":"Sahoo","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s10495-022-01780-7","article-title":"BCL-2 Protein Family: Attractive Targets for Cancer Therapy","volume":"28","author":"Kaloni","year":"2023","journal-title":"Apoptosis"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.micpath.2018.09.032","article-title":"Enterotoxigenic Escherichia coli Infection Promotes Apoptosis in Piglets","volume":"125","author":"Xia","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1128\/IAI.70.8.4669-4677.2002","article-title":"Escherichia coli Shiga-like Toxins Induce Apoptosis and Cleavage of Poly(ADP-Ribose) Polymerase via in Vitro Activation of Caspases","volume":"70","author":"Ching","year":"2002","journal-title":"Infect. Immun."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hao, Y., Xing, M., and Gu, X. (2021). Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs. Animals, 11.","DOI":"10.3390\/ani11051384"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Novais, A.K., Desch\u00eane, K., Martel-Kennes, Y., Roy, C., Laforest, J.P., Lessard, M., Matte, J.J., and Lapointe, J. (2021). Weaning Differentially Affects Mitochondrial Function, Oxidative Stress, Inflammation and Apoptosis in Normal and Low Birth Weight Piglets. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0247188"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/anu.13094","article-title":"Beneficial Effects on Growth, Haematic Indicators, Immune Status, Antioxidant Function and Gut Health in Juvenile Nile Tilapia (Oreochromis niloticus) by Dietary Administration of a Multi-Strain Probiotic","volume":"26","author":"Chen","year":"2020","journal-title":"Aquac. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Yu, Y., Li, Q., Zeng, X., Xu, Y., Jin, K., Liu, J., and Cao, G. (2022). Effects of Probiotics on the Growth Performance, Antioxidant Functions, Immune Responses, and Caecal Microbiota of Broilers Challenged by Lipopolysaccharide. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.846649"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1152\/physrev.00010.2014","article-title":"Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications","volume":"96","author":"Lei","year":"2015","journal-title":"Physiol. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"116986","DOI":"10.1016\/j.lfs.2019.116986","article-title":"The Role of Nrf2 Signaling in Cancer Stem Cells: From Stemness and Self-Renewal to Tumorigenesis and Chemoresistance","volume":"239","author":"Kahroba","year":"2019","journal-title":"Life Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.cellsig.2016.05.007","article-title":"Bridges between Mitochondrial Oxidative Stress, ER Stress and MTOR Signaling in Pancreatic \u03b2 Cells","volume":"28","author":"Wang","year":"2016","journal-title":"Cell. Signal."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/cdd.2010.191","article-title":"The Beclin 1 Network Regulates Autophagy and Apoptosis","volume":"18","author":"Kang","year":"2011","journal-title":"Cell Death Differ."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1631\/jzus.B2200674","article-title":"Engineered Bacillus Subtilis Alleviates Intestinal Oxidative Injury through Nrf2-Keap1 Pathway in Enterotoxigenic Escherichia coli (ETEC) K88-Infected Piglet","volume":"24","author":"Wen","year":"2023","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u039aB Signaling in Inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1087262","article-title":"Role of Adaptor TRIF in the MyD88-Independent Toll-like Receptor Signaling Pathway","volume":"301","author":"Yamamoto","year":"2003","journal-title":"Science"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Li, H., Liu, X., Shang, Z., and Qiao, J. (2021). Clostridium butyricum Helps to Alleviate Inflammation in Weaned Piglets Challenged with Enterotoxigenic Escherichia coli K88. Front. Vet. Sci., 8.","DOI":"10.3389\/fvets.2021.683863"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Li, H., Zhang, L., Chen, L., Zhu, Q., Wang, W., and Qiao, J. (2016). Lactobacillus acidophilus Alleviates the Inflammatory Response to Enterotoxigenic Escherichia coli K88 via Inhibition of the NF-\u039aB and P38 Mitogen-Activated Protein Kinase Signaling Pathways in Piglets. BMC Microbiol., 16.","DOI":"10.1186\/s12866-016-0862-9"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Liu, D., Zhang, S., Li, S., Zhang, Q., Cai, Y., Li, P., Li, H., Shen, B., Liao, Q., and Hong, Y. (2023). Indoleacrylic Acid Produced by Parabacteroides distasonis Alleviates Type 2 Diabetes via Activation of AhR to Repair Intestinal Barrier. BMC Biol., 21.","DOI":"10.1186\/s12915-023-01578-2"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/carcin\/bgaa018","article-title":"Parabacteroides distasonis Attenuates Tumorigenesis, Modulates Inflammatory Markers and Promotes Intestinal Barrier Integrity in Azoxymethane-Treated A\/J Mice","volume":"41","author":"Koh","year":"2021","journal-title":"Carcinogenesis"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jff.2016.06.032","article-title":"Colon Microbiota Fermentation of Dietary Prebiotics towards Short-Chain Fatty Acids and Their Roles as Anti-Inflammatory and Antitumour Agents: A Review","volume":"25","author":"Villar","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12964-022-00869-5","article-title":"Regulatory Role of Short-Chain Fatty Acids in Inflammatory Bowel Disease","volume":"20","author":"Zhang","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3748\/wjg.v23.i1.60","article-title":"Sodium Butyrate Attenuates High-Fat Diet-Induced Steatohepatitis in Mice by Improving Gut Microbiota and Gastrointestinal Barrier","volume":"23","author":"Zhou","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s11033-021-06991-w","article-title":"Effects of Valerate on Intestinal Barrier Function in Cultured Caco-2 Epithelial Cell Monolayers","volume":"49","author":"Gao","year":"2022","journal-title":"Mol. Biol. 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