{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:51:36Z","timestamp":1789429896982,"version":"build-2803163510"},"reference-count":44,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidade de Bras\u00edlia","award":["23106.067374\/2024-16"],"award-info":[{"award-number":["23106.067374\/2024-16"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Cardiac congenital defects related to inheritance and teratogenesis have been reported in veterinary species and humans worldwide. Among these, ectopia cordis (EC), characterized by an externalized heart through a cleft, is extremely rare in sheep. This report presents the diagnostic features of two cases of complete thoracic EC in newborn lambs. Clinical findings in the lambs, aside from the EC, were unremarkable. Both animals exhibited exteriorized hearts without pericardial coverage, delineated in the thoracic cleft by a fibrous ring of the pericardium and adjacent skin. Histologically, the epicardium was thickened by fibrous tissue in both lambs, with one animal also showing marked edema, hemorrhage, and neutrophilic inflammatory infiltration. The prognosis of EC in the lambs of this study was poor, with fatal outcomes despite attempts at surgical correction.<\/jats:p>","DOI":"10.3390\/ani14152213","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T15:25:23Z","timestamp":1722353123000},"page":"2213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Complete Thoracic Ectopia Cordis in Two Lambs"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6353-6238","authenticated-orcid":false,"given":"Liz de Albuquerque","family":"Cerqueira","sequence":"first","affiliation":[{"name":"Veterinary Pathology Laboratory, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Bras\u00edlia 70910-900, Distrito Federal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7327-9143","authenticated-orcid":false,"given":"Isabel Luana de","family":"M\u00e2cedo","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Laboratory, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Bras\u00edlia 70910-900, Distrito Federal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1237-0693","authenticated-orcid":false,"given":"Davi Emanuel Ribeiro de","family":"Sousa","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Laboratory, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Bras\u00edlia 70910-900, Distrito Federal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1969-5709","authenticated-orcid":false,"given":"Haiane Arruda Luz","family":"Amorim","sequence":"additional","affiliation":[{"name":"Large Animal Veterinary Teaching Hospital, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Bras\u00edlia 70636-200, Distrito Federal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-4432","authenticated-orcid":false,"given":"Jos\u00e9 Renato Junqueira","family":"Borges","sequence":"additional","affiliation":[{"name":"Large Animal Veterinary Teaching Hospital, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Bras\u00edlia 70636-200, Distrito Federal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Henrique Bezerra","family":"Ximenes","sequence":"additional","affiliation":[{"name":"Large Animal Veterinary Teaching Hospital, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Bras\u00edlia 70636-200, Distrito Federal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6895-7210","authenticated-orcid":false,"given":"Antonio Carlos Lopes","family":"C\u00e2mara","sequence":"additional","affiliation":[{"name":"Large Animal Veterinary Teaching Hospital, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Bras\u00edlia 70636-200, Distrito Federal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-0856","authenticated-orcid":false,"given":"M\u00e1rcio Botelho de","family":"Castro","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Laboratory, College of Agronomy and Veterinary Medicine, Universidade de Bras\u00edlia, Bras\u00edlia 70910-900, Distrito Federal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1177\/030098589303000606","article-title":"Cervical-pectoral ectopia cordis in two Holstein calves","volume":"30","author":"Hiraga","year":"1993","journal-title":"Vet. 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