{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:58:59Z","timestamp":1790614739828,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>To investigate the possible protective effect of hesperidin on intestinal damage caused by high-temperature heat stress in yellow-feathered broilers, 960 broilers aged 21 days were randomly divided into four groups: HT, HT300, HT450, and HT600, with each group receiving different amounts of hesperidin supplementation (0, 300, 450, and 600 mg\/kg). The dietary supplementation of hesperidin could mitigate the elevation of corticosterone (CORT) and adrenocorticotropic hormone (ATCH) levels in serum from yellow-feathered broilers induced by heat stress. The supplementation of 300 mg\/kg and 450 mg\/kg of hesperidin reduced crypt depth and increased the V\/C ratio in the small intestine compared to the HT group. The dietary supplementation of hesperidin decreased endotoxin and D-lactic acid levels in the blood, and dietary supplementation of 300 mg\/kg of hesperidin increased the expression of claudin-1 and ZO-1 mRNA in the jejunum compared with the HT group. Furthermore, the dietary supplementation of 300 mg\/kg of hesperidin decreased serum IL-1\u03b2 and IL-6 levels. In comparison, supplementation with 300 mg\/kg and 450 mg\/kg of hesperidin decreased serum TNF-\u03b1 levels in yellow-feathered broilers compared to the HT group. Moreover, the dietary supplementation of hesperidin decreased NF-\u03baB mRNA levels. Overall, these data suggest that dietary supplementation with hesperidin potentially improves intestinal injury caused by heat stress in yellow-feathered broilers.<\/jats:p>","DOI":"10.3390\/ani14172585","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T06:44:29Z","timestamp":1725518669000},"page":"2585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hesperidin Helps Improve the Intestinal Structure, Maintain Barrier Function, and Reduce Inflammation in Yellow-Feathered Broilers Exposed to High Temperatures"],"prefix":"10.3390","volume":"14","author":[{"given":"Shaoping","family":"He","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"},{"name":"Animal Husbandry and Fisheries Research Center of Guangdong Haid Group Co., Ltd., Guangzhou 511400, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhi","family":"Bian","sequence":"additional","affiliation":[{"name":"Animal Husbandry and Fisheries Research Center of Guangdong Haid Group Co., Ltd., Guangzhou 511400, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu","family":"Guo","sequence":"additional","affiliation":[{"name":"Animal Husbandry and Fisheries Research Center of Guangdong Haid Group Co., Ltd., Guangzhou 511400, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3390\/ani3020356","article-title":"Impact of Heat Stress on Poultry Production","volume":"3","author":"Lara","year":"2013","journal-title":"Animals"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00484-020-02023-7","article-title":"Heat stress and poultry production: Impact and amelioration","volume":"65","author":"Vandana","year":"2021","journal-title":"Int. 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