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Selenium (Se) is an essential element for pigs, with documented roles encompassing antioxidative and anti-inflammatory properties via selenoproteins. Sodium selenite and Se-enriched yeast are commonly acknowledged as conventional sources of Se for piglets. In the past decade, several novel Se sources have emerged in the field of weaned piglet nutrition. In this review, we will initially outline the historical timeline of Se sources as reported in weaned piglet nutrition. Afterwards, our attention will turn towards the nutritional regulation of Se sources in relation to the antioxidant and anti-inflammatory aspects of healthy weaned piglets. Ultimately, we will provide a detailed review highlighting the potential of emerging Se sources in alleviating various adverse effects of stress challenges faced by weaned piglets. These challenges include oxidative stress, enterotoxigenic Escherichia coli infection, lipopolysaccharide-induced inflammation, heat stress, and exposure to feed mycotoxins. The output of this review will emphasize the fundamental importance of incorporating emerging Se sources in the diet of weaned piglets.<\/jats:p>","DOI":"10.3390\/ani14172599","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T09:20:29Z","timestamp":1725614429000},"page":"2599","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An Updated Review of Emerging Sources of Selenium in Weaned Piglet Nutrition"],"prefix":"10.3390","volume":"14","author":[{"given":"Wenyue","family":"Zhou","sequence":"first","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Han","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5651-4014","authenticated-orcid":false,"given":"Xingping","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiande","family":"Zou","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"You","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5037-3479","authenticated-orcid":false,"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.15406\/ijawb.2023.07.00187","article-title":"Review on diseases and health management of poultry and swine","volume":"7","author":"Serbessa","year":"2023","journal-title":"Int. J. Avian Wildl. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11495","DOI":"10.1073\/pnas.1806068115","article-title":"Global trends in infectious diseases of swine","volume":"115","author":"VanderWaal","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Tang, X., Xiong, K., Fang, R., and Li, M. (2022). Weaning stress and intestinal health of piglets: A review. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1042778"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Van Kerschaver, C., Turpin, D., Michiels, J., and Pluske, J. (2023). Reducing weaning stress in piglets by pre-weaning socialization and gradual separation from the sow: A review. Animals, 13.","DOI":"10.3390\/ani13101644"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2527\/jas.2015-9767","article-title":"Invited review: Aspects of gastrointestinal tract growth and maturation in the pre- and postweaning period of pigs","volume":"94","author":"Pluske","year":"2016","journal-title":"J. Anim. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Modina, S.C., Polito, U., Rossi, R., Corino, C., and Di Giancamillo, A. (2019). Nutritional regulation of gut barrier integrity in weaning piglets. Animals, 9.","DOI":"10.3390\/ani9121045"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Novais, A.K., Desch\u00eane, K., Martel-Kennes, Y., Roy, C., Laforest, J.-P., Lessard, M., Matte, J.J., and Lapointe, J. (2021). Weaning differentially affects mitochondrial function, oxidative stress, inflammation and apoptosis in normal and low birth weight piglets. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0247188"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"612","DOI":"10.2527\/jas.2013-6986","article-title":"Development of an antioxidant system after early weaning in piglets","volume":"92","author":"Yin","year":"2014","journal-title":"J. Anim. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.2527\/jas.2011-4444","article-title":"Impact of weaning and an antioxidant blend on intestinal barrier function and antioxidant status in pigs","volume":"90","author":"Zhu","year":"2012","journal-title":"J. Anim. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10142-014-0396-x","article-title":"Gut response induced by weaning in piglet features marked changes in immune and inflammatory response","volume":"14","author":"Bomba","year":"2014","journal-title":"Funct. Integr. Genom."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/jn\/134.3.641","article-title":"Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets","volume":"134","author":"Blazy","year":"2004","journal-title":"J. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"100818","DOI":"10.1016\/j.animal.2023.100818","article-title":"Influence of body lesion severity on oxidative status and gut microbiota of weaned pigs","volume":"17","author":"Correa","year":"2023","journal-title":"Animal"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.fct.2013.05.033","article-title":"Effects of zearalenone on oxidative stress and inflammation in weanling piglets","volume":"58","author":"Marin","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1021\/jf300249j","article-title":"Effects of selenium-enriched probiotics on heat shock protein mRNA levels in piglet under heat stress conditions","volume":"61","author":"Gan","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Wu, Z., Zhang, L., Li, H., Li, J., Zhang, Z., Tan, B., and Wang, J. (2024). Ningxiang pig-derived Parabacteroides distasonis HNAU0205 alleviates ETEC-induced intestinal apoptosis, oxidative damage, and inflammation in piglets. Animals, 14.","DOI":"10.3390\/ani14152156"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Hu, X., Zhong, S., Yu, W., Wang, J., Zhu, W., Yang, T., Zhao, G., Jiang, Y., and Li, Y. (2022). Effects of continuous LPS induction on oxidative stress and liver injury in weaned piglets. Vet. Sci., 10.","DOI":"10.3390\/vetsci10010022"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zoidis, E., Seremelis, I., Kontopoulos, N., and Danezis, G.P. (2018). Selenium-dependent antioxidant enzymes: Actions and properties of selenoproteins. Antioxidants, 7.","DOI":"10.3390\/antiox7050066"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Avery, J.C., and Hoffmann, P.R. (2018). Selenium, selenoproteins, and immunity. Nutrients, 10.","DOI":"10.3390\/nu10091203"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.anifeedsci.2015.11.006","article-title":"Selenium in sow nutrition","volume":"211","author":"Surai","year":"2016","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"730","DOI":"10.5713\/ajas.14.0593","article-title":"Selenium in pig nutrition and reproduction: Boars and semen quality\u2014A review","volume":"28","author":"Surai","year":"2015","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.anifeedsci.2018.01.020","article-title":"The influence of selenium and selenoproteins on immune responses of poultry and pigs","volume":"238","author":"Dalgaard","year":"2018","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.anifeedsci.2016.08.022","article-title":"Selenium and vitamin E in sow diets: I. Effect on antioxidant status and reproductive performance in multiparous sows","volume":"221","author":"Chen","year":"2016","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.anifeedsci.2016.08.021","article-title":"Selenium and vitamin E in sow diets: II. Effect on selenium status and antioxidant status of the progeny","volume":"221","author":"Chen","year":"2016","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jtemb.2019.07.004","article-title":"Increasing selenium supplementation to a moderately-reduced energy and protein diet improves antioxidant status and meat quality without affecting growth performance in finishing pigs","volume":"56","author":"Chen","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.anifeedsci.2006.03.020","article-title":"Effects of different selenium source on selenium distribution, loin quality and antioxidant status in finishing pigs","volume":"132","author":"Zhan","year":"2007","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.2527\/jas.2006-067","article-title":"Efficacy of dietary selenium sources on growth and carcass characteristics of growing-finishing pigs fed diets containing high endogenous selenium","volume":"85","author":"Mateo","year":"2007","journal-title":"J. Anim. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2527\/jas1978.462384x","article-title":"Effect of increasing the level of inorganic selenium supplementation in the post-weaning diets of swine","volume":"46","author":"Mahan","year":"1978","journal-title":"J. Anim. Sci."},{"key":"ref_28","first-page":"5","article-title":"Effects of organic selenium yeast administration on perinatal performance, growth efficiency and health status in pigs","volume":"14","author":"Zavodnik","year":"2011","journal-title":"Arch. Zootech."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Cao, J., Guo, F., Zhang, L., Dong, B., and Gong, L. (2014). Effects of dietary selenomethionine supplementation on growth performance, antioxidant status, plasma selenium concentration, and immune function in weaning pigs. J. Anim. Sci. Biotechnol., 5.","DOI":"10.1186\/2049-1891-5-46"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/1745039X.2019.1641368","article-title":"Effects of different levels of dietary hydroxy-analogue of selenomethionine on growth performance, selenium deposition and antioxidant status of weaned piglets","volume":"73","author":"Chao","year":"2019","journal-title":"Arch. Anim. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"114381","DOI":"10.1016\/j.anifeedsci.2019.114381","article-title":"Supplemental hot melt extruded nano-selenium increases expression profiles of antioxidant enzymes in the livers and spleens of weanling pigs","volume":"262","author":"Lee","year":"2020","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_32","first-page":"385","article-title":"Effects of organic selenium on growth properties, selenium absorption and utilization, antioxidant activity and immunity in weaning piglets","volume":"11","author":"Zhang","year":"2020","journal-title":"Food Nutr. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Wang, D., Zhang, Y., Chen, Q., Kuang, Y., Fan, J., Xu, X., Zhu, H., Gao, Q., Cheng, S., and Cong, X. (2022). Selenium-enriched Cardamine violifolia improves growth performance with potential regulation of intestinal health and antioxidant function in weaned pigs. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.964766"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Conway, E., Sweeney, T., Dowley, A., Vigors, S., Ryan, M., Yadav, S., Wilson, J., and O\u2019Doherty, J.V. (2022). Selenium-enriched mushroom powder enhances intestinal health and growth performance in the absence of zinc oxide in post-weaned pig diets. Animals, 12.","DOI":"10.3390\/ani12121503"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Dowley, A., Sweeney, T., Conway, E., Vigors, S., Ryan, M.T., Yadav, S., Wilson, J., and O\u2019Doherty, J.V. (2023). The effects of dietary supplementation with mushroom or selenium enriched mushroom powders on the growth performance and intestinal health of post-weaned pigs. J. Anim. Sci. Biotechnol., 14.","DOI":"10.1186\/s40104-022-00808-x"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"txad049","DOI":"10.1093\/tas\/txad049","article-title":"Evaluation of selenium source on nursery pig growth performance, serum and tissue selenium concentrations, and serum antioxidant status","volume":"7","author":"Rao","year":"2023","journal-title":"Transl. Anim. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.aninu.2023.08.003","article-title":"Replacing dietary sodium selenite with biogenic selenium nanoparticles improves the growth performance and gut health of early-weaned piglets","volume":"15","author":"Qiao","year":"2023","journal-title":"Anim. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1017\/S0007114520000689","article-title":"Organic selenium supplement partially alleviated diquat-induced oxidative insults and hepatic metabolic stress in nursery pigs","volume":"124","author":"Doan","year":"2020","journal-title":"Br. J. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"115448","DOI":"10.1016\/j.ecoenv.2023.115448","article-title":"Mannan oligosaccharides selenium ameliorates intestinal mucosal barrier, and regulate intestinal microbiota to prevent Enterotoxigenic Escherichia coli-induced diarrhea in weaned piglets","volume":"264","author":"Zha","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s12011-023-03713-0","article-title":"Selenium-enriched Cardamine violifolia alleviates LPS-induced hepatic damage and inflammation by suppressing TLR4\/NODs\u2013necroptosis signal axes in piglets","volume":"202","author":"Wang","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1007\/s11427-022-2274-7","article-title":"Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs","volume":"66","author":"Wang","year":"2023","journal-title":"Sci. China Life Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/jpn.12326","article-title":"Effects of dietary supplementation of selenium-enriched probiotics on production performance and intestinal microbiota of weanling piglets raised under high ambient temperature","volume":"99","author":"Lv","year":"2015","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1021\/jf501065d","article-title":"Selenium-enriched probiotics improve antioxidant status, immune function, and selenoprotein gene expression of piglets raised under high ambient temperature","volume":"62","author":"Gan","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.rvsc.2021.07.007","article-title":"Effects of selenium-enriched probiotics on ochratoxin A-induced kidney injury and DNMTs expressions in piglets","volume":"139","author":"Gan","year":"2021","journal-title":"Res. Vet. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Qin, S., Peng, Y., She, F., Zhang, J., Li, L., and Chen, F. (2023). Positive effects of selenized-oligochitosan on zearalenone-induced intestinal dysfunction in piglets. Front. Vet. Sci., 10.","DOI":"10.3389\/fvets.2023.1184969"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Zhong, H., Huang, Z., Li, L., Chen, X., Zou, T., Chen, J., and You, J. (2024). Selenomethionine supplementation mitigates liver dysfunction, oxidative injury and apoptosis through enhancing antioxidant capacity and inhibiting JNK MAPK pathway in piglets fed deoxynivalenol-contaminated diets. Antioxidants, 13.","DOI":"10.3390\/antiox13030295"},{"key":"ref_47","first-page":"1037","article-title":"The role of vitamin E and selenium in the nutrition of the pig","volume":"16","author":"Eggert","year":"1957","journal-title":"J. Anim. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Edmunds, C.E., Welch, C.B., Lourenco, J.M., Callaway, T.R., Pringle, T.D., and Dove, C.R. (2023). The effects of dietary manganese and selenium on growth and the fecal microbiota of nursery piglets. Vet. Sci., 10.","DOI":"10.3390\/vetsci10110650"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"105100","DOI":"10.1016\/j.livsci.2022.105100","article-title":"The effect of varying dietary manganese and selenium levels on the growth performance and manganese-superoxide dismutase activity in nursery pigs","volume":"265","author":"Edmunds","year":"2022","journal-title":"Livest. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Liu, L., Chen, D., Yu, B., Luo, Y., Huang, Z., Zheng, P., Mao, X., Yu, J., Luo, J., and Yan, H. (2021). Influences of selenium-enriched yeast on growth performance, immune function, and antioxidant capacity in weaned pigs exposure to oxidative stress. BioMed Res. Int., 2021.","DOI":"10.1155\/2021\/5533210"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5490743","DOI":"10.1155\/2020\/5490743","article-title":"Selenium-enriched yeast alleviates oxidative stress-induced intestinal mucosa disruption in weaned pigs","volume":"2020","author":"Liu","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/1753425919888566","article-title":"Comparative study of yeast selenium vs. sodium selenite on growth performance, nutrient digestibility, anti-inflammatory and anti-oxidative activity in weaned piglets challenged by Salmonella typhimurium","volume":"26","author":"Lv","year":"2020","journal-title":"Innate Immun."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Papakonstantinou, G.I., Meletis, E., Petrotos, K., Kostoulas, P., Tsekouras, N., Kantere, M.C., Voulgarakis, N., Gougoulis, D., Filippopoulos, L., and Christodoulopoulos, G. (2023). Effects of a natural polyphenolic product from olive mill wastewater on oxidative stress and post-weaning diarrhea in piglets. Agriculture, 13.","DOI":"10.3390\/agriculture13071356"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2018.04.560","article-title":"Evolution, regulation, and function of porcine selenogenome","volume":"127","author":"Chen","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Roh, Y.J., Han, S.-J., Park, I., Lee, H.M., Ok, Y.S., Lee, B.C., and Lee, S.-R. (2020). Role of selenoproteins in redox regulation of signaling and the antioxidant system: A review. Antioxidants, 9.","DOI":"10.3390\/antiox9050383"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Campbell, J.M., Crenshaw, J.D., and Polo, J. (2013). The biological stress of early weaned piglets. J. Anim. Sci. Biotechnol., 4.","DOI":"10.1186\/2049-1891-4-19"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"338","DOI":"10.5713\/ab.21.0010","article-title":"Understanding intestinal health in nursery pigs and the relevant nutritional strategies","volume":"34","author":"Kim","year":"2021","journal-title":"Anim. Biosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/jas\/skx062","article-title":"Weaning disrupts intestinal antioxidant status, impairs intestinal barrier and mitochondrial function, and triggers mitophagy in piglets","volume":"96","author":"Cao","year":"2018","journal-title":"J. Anim. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Jin, S., Xu, H., Yang, C., and Karmin, O. (2024). Regulation of oxidative stress in the intestine of piglets after enterotoxigenic Escherichia coli (ETEC) infection. Biochim. Biophys. Acta Mol. Cell Res., 1871.","DOI":"10.1016\/j.bbamcr.2024.119711"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.aninu.2017.10.001","article-title":"Intestinal challenge with enterotoxigenic Escherichia coli in pigs, and nutritional intervention to prevent postweaning diarrhea","volume":"3","author":"Sun","year":"2017","journal-title":"Anim. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/jpn.13540","article-title":"Seaweed polysaccharide mitigates intestinal barrier dysfunction induced by enterotoxigenic Escherichia coli through NF\u2014\u03baB pathway suppression in porcine intestinal epithelial cells","volume":"105","author":"Guo","year":"2021","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Kim, K., Song, M., Liu, Y., and Ji, P. (2022). Enterotoxigenic Escherichia coli infection of weaned pigs: Intestinal challenges and nutritional intervention to enhance disease resistance. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.885253"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jff.2018.05.015","article-title":"Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model","volume":"46","author":"Wang","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/jpn.13071","article-title":"Spray-dried porcine plasma improves feed intake of weaned piglets subjected to heat stress","volume":"103","author":"Schinckel","year":"2019","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_65","first-page":"91","article-title":"Evaluating the behavior, growth performance, immune parameters, and intestinal morphology of weaned piglets after simulated transport and heat stress when antibiotics are eliminated from the diet or replaced with L-glutamine","volume":"95","author":"Johnson","year":"2017","journal-title":"J. Anim. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.aninu.2016.03.001","article-title":"Impact of mycotoxin on immune response and consequences for pig health","volume":"2","author":"Pierron","year":"2016","journal-title":"Anim. Nutr."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Huang, Z., Zhong, H., Li, T., Wang, Z., Chen, X., Zou, T., You, J., and Chen, J. (2024). Selenomethionine alleviates deoxynivalenol-induced oxidative injury in porcine intestinal epithelial cells independent of MAPK pathway regulation. Antioxidants, 13.","DOI":"10.3390\/antiox13030356"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Chen, J., Huang, Z., Cao, X., Chen, X., Zou, T., and You, J. (2022). Plant-derived polyphenols as Nrf2 activators to counteract oxidative stress and intestinal toxicity induced by deoxynivalenol in swine: An emerging research direction. Antioxidants, 11.","DOI":"10.3390\/antiox11122379"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.micpath.2018.02.035","article-title":"Post-weaning piglets fed with different levels of fungal mycotoxins and spray-dried porcine plasma have improved weight gain, feed intake and reduced diarrhea incidence","volume":"117","author":"Paiano","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Khoi, C.-S., Chen, J.-H., Lin, T.-Y., Chiang, C.-K., and Hung, K.-Y. (2021). Ochratoxin A-induced nephrotoxicity: Up-to-date evidence. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011237"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Han, Y., Zhan, T., Tang, C., Zhao, Q., Dansou, D.M., Yu, Y., Barbosa, F.F., and Zhang, J. (2021). Effect of replacing in-feed antibiotic growth promoters with a combination of egg immunoglobulins and phytomolecules on the performance, serum immunity, and intestinal health of weaned pigs challenged with Escherichia coli K88. Animals, 11.","DOI":"10.3390\/ani11051292"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Xu, B., Fu, J., Zhu, L., Li, Z., Jin, M., and Wang, Y. (2021). Overall assessment of antibiotic substitutes for pigs: A set of meta-analyses. J. Anim. Sci. Biotechnol., 12.","DOI":"10.1186\/s40104-020-00534-2"},{"key":"ref_73","first-page":"992","article-title":"Hot melt extruded-based nano zinc as an alternative to the pharmacological dose of ZnO in weanling piglets","volume":"33","author":"Oh","year":"2020","journal-title":"Asian-Australas. J. Anim. Sci."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/17\/2599\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:49:52Z","timestamp":1760111392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/17\/2599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":73,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["ani14172599"],"URL":"https:\/\/doi.org\/10.3390\/ani14172599","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,6]]}}}