{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:25:45Z","timestamp":1760145945329,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Radioiodine therapy (RAIT) is the gold standard for treatment of hyperthyroidism in cats. The aim of this study was to evaluate the effect of the presence of uni- or bilateral thyroid adenoma on changes in total thyroxine (TT4), thyroid-stimulating hormone (TSH), and creatinine concentration over a period of 6 to 12 months following RAIT. Fifty-one hyperthyroid cats presented for RAIT between April 2021 and April 2022 were prospectively enrolled. Cats with an increased creatinine concentration (creatinine \u2265 140 \u00b5mol\/L), renal morphology abnormalities, and suspected thyroid carcinoma were excluded. TT4, TSH, and creatinine were determined before and one week and one, three, six, and twelve months following RAIT. The effects of the re-examination timepoint following RAIT and the presence of uni- or bilateral thyroid adenoma based on technetium-99m scintigraphy on TT4, TSH, and creatinine were analysed by mixed effects modelling. Cats with bilateral adenoma had significantly higher TSH concentrations after RAIT compared to those with unilateral adenoma. TT4 concentration significantly decreased one week (p &lt; 0.001) and again one month following RAIT (p &lt; 0.001). TSH and creatinine concentration significantly increased one month post RAIT (both p &lt; 0.001). As indicated by an increase in TSH concentration, the pituitary\u2013thyroid axis needs a minimum of one month post RAIT to recover from hyperthyroidism-induced suppression, but hypothyroidism necessitating levothyroxine supplementation might not be diagnosed before 6 or even 12 months post RAIT. Although creatinine did not increase significantly after one month post RAIT in this cohort, an increased creatinine concentration was detected at later timepoints in individual cats.<\/jats:p>","DOI":"10.3390\/ani14182627","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T07:33:25Z","timestamp":1725953605000},"page":"2627","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Presence of Uni- or Bilateral Thyroid Adenoma on Recovery of Pituitary\u2013Thyroid Axis and Creatinine Concentration in Radioiodine-Treated Cats"],"prefix":"10.3390","volume":"14","author":[{"given":"Anna Paulina","family":"Menzel","sequence":"first","affiliation":[{"name":"Clinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig University of Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Lin","sequence":"additional","affiliation":[{"name":"Clinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig University of Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"G\u00fcssow","sequence":"additional","affiliation":[{"name":"Clinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig University of Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ve","family":"Patzelt","sequence":"additional","affiliation":[{"name":"Clinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig University of Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natali","family":"Bauer","sequence":"additional","affiliation":[{"name":"Clinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig University of Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7185-0446","authenticated-orcid":false,"given":"Katarina","family":"Hazuchova","sequence":"additional","affiliation":[{"name":"Clinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig University of Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jfms.2008.08.001","article-title":"Prevalence of and risk factors for feline hyperthyroidism in Hong Kong","volume":"11","author":"Mooney","year":"2009","journal-title":"J. Feline Med. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1939-1676.2011.00790.x","article-title":"Evaluation of Predictors for the Diagnosis of Hyperthyroidism in Cats","volume":"25","author":"Wakeling","year":"2011","journal-title":"J. Vet. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1136\/vr.102431","article-title":"Feline hyperthyroidism reported in primary-care veterinary practices in England: Prevalence, associated factors and spatial distribution","volume":"175","author":"Stephens","year":"2014","journal-title":"Vet. Rec."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2478\/bvip-2014-0040","article-title":"Prevalence of feline hyperthyroidism in mature cats in urban population in Warsaw","volume":"58","author":"Lechowski","year":"2014","journal-title":"Bull. Vet. Inst. Pulawy"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.15654\/TPK-150590","article-title":"Pr\u00e4valenz und Risikofaktoren der felinen Hyperthyreose in einer Klinikpopulation in S\u00fcddeutschland","volume":"44","author":"Ballhausen","year":"2016","journal-title":"Tieraerztliche Prax. Ausg. Kleintiere Heimtiere"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.2460\/javma.1995.207.11.1422","article-title":"Radioiodine treatment of 524 cats with hyperthyroidism","volume":"207","author":"Peterson","year":"1995","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/jsap.12695","article-title":"Serum thyroxine and thyroid-stimulating hormone concentration in hyperthyroid cats that develop azotaemia after radioiodine therapy","volume":"58","author":"Peterson","year":"2017","journal-title":"J. Small Anim. Pr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/jvim.13585","article-title":"Evaluation of Serum Thyroid-Stimulating Hormone Concentration as a Diagnostic Test for Hyperthyroidism in Cats","volume":"29","author":"Peterson","year":"2015","journal-title":"J. Vet. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1740-8261.1997.tb00846.x","article-title":"Changes in renal function in cats following treatment of hyperthyroidism using 131I","volume":"38","author":"Adamss","year":"1997","journal-title":"Vet. Radiol. Ultrasound"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/vr.161.21.711","article-title":"Changes in the glomerular filtration rate of 27 cats with hyperthyroidism after treatment with radioactive iodine","volume":"161","author":"Boag","year":"2007","journal-title":"Vet. Rec."},{"key":"ref_11","first-page":"45","article-title":"Short- and long-term follow-up of glomerular and tubular renal markers of kidney function in hyperthyroid cats after treatment with radioiodine","volume":"36","author":"Lefebvre","year":"2008","journal-title":"Domest. Anim. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/jvim.14646","article-title":"Efficacy of Low-dose (2 millicurie) versus Standard-dose (4 millicurie) Radioiodine Treatment for Cats with Mild-to-Moderate Hyperthyroidism","volume":"31","author":"Lucy","year":"2017","journal-title":"J. Vet. Intern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/jvim.15036","article-title":"Evaluation of Serum Symmetric Dimethylarginine Concentration as a Marker for Masked Chronic Kidney Disease in Cats with Hyperthyroidism","volume":"32","author":"Peterson","year":"2018","journal-title":"J. Vet. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1111\/jvim.16849","article-title":"Urine concentrating ability in cats with hyperthyroidism: Influence of radioiodine treatment, masked azotemia, and iatrogenic hypothyroidism","volume":"37","author":"Peterson","year":"2023","journal-title":"J. Vet. Intern. Med."},{"key":"ref_15","unstructured":"IRIS (2024, July 15). Staging of CKD (Modified 2023). Available online: http:\/\/www.iris-kidney.com\/pdf\/2_IRIS_Staging_of_CKD_2023.pdf."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1111\/jvim.16228","article-title":"A dosing algorithm for individualized radioiodine treatment of cats with hyperthyroidism","volume":"35","author":"Peterson","year":"2021","journal-title":"J. Vet. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"E258","DOI":"10.1177\/1098612X221104743","article-title":"Radioiodine treatment of hyperthyroidism in cats: Results of 165 cats treated by an individualised dosing algorithm in Spain","volume":"24","author":"Xifra","year":"2022","journal-title":"J. Feline Med. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1177\/1098612X15576587","article-title":"Effect of thyroid volume on radioiodine therapy outcome in hyperthyroid cats","volume":"18","author":"Volckaert","year":"2016","journal-title":"J. Feline Med. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/jvim.16319","article-title":"Predicting outcomes in hyperthyroid cats treated with radioiodine","volume":"36","author":"Peterson","year":"2022","journal-title":"J. Vet. Intern. Med."},{"key":"ref_20","first-page":"289","article-title":"Bestimmung von TSH und freien Schilddr\u00fcsenhormonen in der Hyperthyreosediagnostik der Katze","volume":"28","author":"Puille","year":"2000","journal-title":"Tierarztl. Prax. Ausg. K Kleintiere-Heimtiere"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1055\/s-0038-1622651","article-title":"Radiojodtherapie der felinen Hyperthyreose: 105 F\u00e4lle","volume":"35","author":"Puille","year":"2007","journal-title":"Tier\u00e4rztliche Prax. Ausg. K Kleintiere-Heimtiere"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1055\/s-0030-1248273","article-title":"Nuklearmedizinische Diagnostik und Therapie der felinen Hyperthyreose","volume":"33","author":"Puille","year":"2010","journal-title":"Nuklearmediziner"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1177\/1098612X18820145","article-title":"Coagulation parameters in hyperthyroid cats before and after radioiodine treatment compared with healthy controls","volume":"21","author":"Cui","year":"2019","journal-title":"J. Feline Med. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/vru.12165","article-title":"Thyroid scintigraphy findings in 2096 cats with hyperthyroidism","volume":"56","author":"Peterson","year":"2015","journal-title":"Vet. Radiol. Ultrasound"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1748-5827.1994.tb03287.x","article-title":"Radioactive iodine therapy for feline hyperthyroidism: Efficacy and administration routes","volume":"35","author":"Mooney","year":"1994","journal-title":"J. Small Anim. Pract."},{"key":"ref_26","first-page":"260","article-title":"Diagnosis and management of iatrogenic hypothyroidism","volume":"7","author":"Peterson","year":"2015","journal-title":"August\u2019s Consult. Feline Intern. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/1098612X16631234","article-title":"ISFM Consensus Guidelines on the Diagnosis and Management of Feline Chronic Kidney Disease","volume":"18","author":"Sparkes","year":"2016","journal-title":"J. Feline Med. Surg."},{"key":"ref_28","first-page":"1","article-title":"Evaluation of a novel, sensitive thyroid-stimulating hormone assay as a diagnostic test for thyroid disease in cats","volume":"1","author":"Peterson","year":"2024","journal-title":"Am. J. Vet. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.2460\/ajvr.1994.55.12.1745","article-title":"Changes in renal function associated with treatment of hyperthyroidism in cats","volume":"55","author":"Graves","year":"1994","journal-title":"Am. J. Vet. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"215","DOI":"10.5326\/15473317-36-3-215","article-title":"Effects of methimazole on renal function in cats with hyperthyroidism","volume":"36","author":"Becker","year":"2000","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1111\/jvim.12359","article-title":"Effect on Renal Function of Restoration of Euthyroidism in Hyperthyroid Cats with Iatrogenic Hypothyroidism","volume":"28","author":"Williams","year":"2014","journal-title":"J. Vet. Intern. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/j.1939-1676.2010.0566.x","article-title":"Association of Iatrogenic Hypothyroidism with Azotemia and Reduced Survival Time in Cats Treated for Hyperthyroidism","volume":"24","author":"Williams","year":"2010","journal-title":"J. Vet. Intern. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/jvim.16930","article-title":"Research communications of the 33rd ECVIM-CA Congress","volume":"38","author":"Silva","year":"2024","journal-title":"J. Vet. Intern. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.5455\/OVJ.2022.v12.i2.11","article-title":"Outcome of radioiodine therapy for feline hyperthyroidism: Fixed dose versus individualized dose based on a clinical scoring system","volume":"12","author":"Matos","year":"2022","journal-title":"Open Vet. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1111\/jvim.15296","article-title":"Investigation of a novel variable dosing protocol for radioiodine treatment of feline hyperthyroidism","volume":"32","author":"Panciera","year":"2018","journal-title":"J. Vet. Intern. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1177\/1098612X18822396","article-title":"Prevalence of iatrogenic hypothyroidism in hyperthyroid cats treated with radioiodine using an individualised scoring system","volume":"21","author":"Fernandez","year":"2019","journal-title":"J. Feline Med. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/jsap.13057","article-title":"Thyroid and renal function in cats following low-dose radioiodine (111Mbq) therapy","volume":"60","author":"Finch","year":"2019","journal-title":"J. Small Anim. Prac."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.2460\/ajvr.1993.54.10.1653","article-title":"Effects of dietary protein and calorie restriction in clinically normal cats and in cats with surgically induced chronic renal failure","volume":"54","author":"Adams","year":"1993","journal-title":"Am. J. Vet. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1748-5827.1994.tb03952.x","article-title":"Evaluation of renal biopsies in cats and dogs\u2014Histopathology in comparison with clinical data","volume":"35","author":"Minkus","year":"1994","journal-title":"J. Small Anim. Prac."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1111\/jvim.15909","article-title":"Correlation of thyroid hormone measurements with thyroid stimulating hormone stimulation test results in radioiodine-treated cats","volume":"34","author":"Wakeling","year":"2020","journal-title":"J. Vet. Intern. Med."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/18\/2627\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:53:03Z","timestamp":1760111583000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/14\/18\/2627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,10]]},"references-count":40,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["ani14182627"],"URL":"https:\/\/doi.org\/10.3390\/ani14182627","relation":{},"ISSN":["2076-2615"],"issn-type":[{"type":"electronic","value":"2076-2615"}],"subject":[],"published":{"date-parts":[[2024,9,10]]}}}