{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T05:47:29Z","timestamp":1771998449090,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Canine paraplegia is a common condition in small animal medicine, referred to as Wei Syndrome (WS) in Traditional Chinese Veterinary Medicine (TCVM). Common clinical manifestations encompass hind limb paralysis, motor dysfunction, muscle atrophy, and the absence of pain perception. WS is considered a difficult-to-treat disease in small animal practice. The objective of this study was to investigate the epidemiology of canine WS and the characteristics of hemorheology. A total of 53 dogs with WS and 53 healthy dogs were included in this study. A retrospective case-controlled study design was employed. Data regarding the gender, season of WS occurrence, breed, and age of dogs with WS, as well as hemorheology from dogs with WS and healthy dogs, were collected and analyzed using SPSS 27.0. The study findings revealed that male dogs were more susceptible to WS (77.36%, 41\/53). WS cases occurred more frequently in Winter (33.96%, 18\/53), and were commonly found in Poodle breeds (43.40%, 23\/53). The most affected age of WS was between 3 and 6 years old (54.72%, 29\/53). Except for plasma viscosity and fibrinogen, the hemorheology indices of canine WS were significantly higher than those of healthy dogs (p &lt; 0.05), especially in male dogs, Poodles and Bulldogs, those between 3 to 10 years, and in Autumn and Winter. This study provides evidence that male Poodles and Bulldogs aged 3 to 6 years are more prone to developing WS, with Winter being the season of high disease incidence. Abnormal hemorheology is a characteristic feature in dogs with WS, which should be considered during the treatment of WS.<\/jats:p>","DOI":"10.3390\/ani14182658","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T10:15:27Z","timestamp":1726136127000},"page":"2658","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiology of Canine Wei Syndrome and Its Hemorheology Characteristics"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4386-4215","authenticated-orcid":false,"given":"Shuo","family":"Yang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6764-2342","authenticated-orcid":false,"given":"Yuting","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Xi\u2019an Veterinary Teaching Hospital, Northwest A&F University, Xi\u2019an 710065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Mi","sequence":"additional","affiliation":[{"name":"Xi\u2019an Veterinary Teaching Hospital, Northwest A&F University, Xi\u2019an 710065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangbo","family":"Tai","sequence":"additional","affiliation":[{"name":"Xi\u2019an Veterinary Teaching Hospital, Northwest A&F University, Xi\u2019an 710065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7846-0056","authenticated-orcid":false,"given":"Wuren","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China"},{"name":"Xi\u2019an Veterinary Teaching Hospital, Northwest A&F University, Xi\u2019an 710065, China"},{"name":"Institute of Traditional Chinese Veterinary Medicine, Northwest A&F University, Yangling 712100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000528047","article-title":"Four Patterns of Canine Wei Syndrome Treated with Traditional Chinese Medicine","volume":"30","author":"Wang","year":"2023","journal-title":"Complement. 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