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Marked reductions in hepatic glycogen and triglycerides occurred from the seventh day of starvation until the end of the trial (p &lt; 0.05). However, no alterations in hepatic cholesterol or protein were detected throughout the entire experiment (p &gt; 0.05). During fasting, the activities of pyruvate kinase, lactate dehydrogenase, and glycogen phosphorylase a all rose firstly and then fell (p &lt; 0.05). The activities of hepatic fatty acid synthase and acetyl-CoA carboxylase were minimized to their lowest levels at the end of food deprivation (p &lt; 0.05), while lipase was elevated after 7\u201314 days of fasting (p &lt; 0.05). Catalase, glutathione, and the total antioxidative capacity were increased and maintained their higher values in the later stage of fasting (p &lt; 0.05), whereas malondialdehyde was not significantly changed (p &gt; 0.05). Hepatic vein congestion, remarkable cytoplasmic vacuoles, and irregular cell shape were present in S. hasta which endured 3\u20137 days of fasting and were less pronounced when food shortage was prolonged. In terms of genes associated with glucose and lipid metabolism, the hepatic phosphofructokinase gene was constantly up-regulated during fasting (p &lt; 0.05). However, the mRNA levels of glycogen synthase and glucose-6-phosphatase were obviously lower when the food scarcity extended to 7 days or more (p &lt; 0.05). Fatty acid synthase, stearoyl-CoA desaturase 1, and peroxisome proliferator-activated receptor \u03b3 were substantially down-regulated in S. hasta livers after 7\u201314 days of food deprivation (p &lt; 0.05). However, genes involved in lipolysis and fatty acid transport were transcriptionally enhanced to varying extents and peaked at the end of fasting (p &lt; 0.05). Overall, starvation lasting 7 days or more could concurrently mobilize hepatic carbohydrates and fat as energy resources and diminished their hepatic accumulation by suppressing biosynthesis and enhancing catabolism and transport, ultimately metabolically and structurally perturbing the liver in S. hasta. This work presents preliminary data on the dynamic characteristics of hepatic glucose and lipid metabolism in S. hasta in response to starvation, which may shed light on the sophisticated mechanisms of energetic homeostasis in fish facing nutrient unavailability and may benefit the utilization\/conservation of S. hasta.<\/jats:p>","DOI":"10.3390\/ani14182734","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T04:45:28Z","timestamp":1727066728000},"page":"2734","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Influence of Starvation on Biochemical, Physiological, Morphological, and Transcriptional Responses Associated with Glucose and Lipid Metabolism in the Liver of Javelin Goby (Synechogobius hasta)"],"prefix":"10.3390","volume":"14","author":[{"given":"Xiangyu","family":"Cui","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Marine Bioresources and 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