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Higher Education Institutions (PAPD)","award":["BK20210808"],"award-info":[{"award-number":["BK20210808"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)","award":["JATS[2023]456"],"award-info":[{"award-number":["JATS[2023]456"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)","award":["8"],"award-info":[{"award-number":["8"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Endometritis represents a prevalent condition in perinatal dairy cows. Bovine endometrial epithelial cells (BEECs), as the primary interface between cavity and the external environment, are particularly vulnerable to infection by pathogenic bacteria following parturition. A20 is essential for regulating inflammation and modulating immune responses. Nevertheless, the exact role of A20 in the BEECs in response to inflammatory response is not fully understood. An endometritis model infected by Escherichia coli (E. coli) in vivo and a BEECs inflammation model induced with lipopolysaccharide (LPS) in vitro were built to investigate the function and governing mechanisms of A20 in endometritis. The results showed that infection with E. coli resulted in endometrial damage, inflammatory cell infiltration, and upregulation of inflammatory factors in dairy cows. Furthermore, A20 expression was upregulated in the endometrium of cows with endometritis and in BEECs following LPS stimulation. A20 overexpression attenuated the level of proinflammatory cytokines in LPS-stimulated BEECs; conversely, A20 knockdown lead to an exacerbated response to LPS stimulation. The overexpression of A20 was shown to activate autophagy and suppress the NF-\u03baB signaling pathway in LPS-stimulated BEECs. However, blocking autophagy with chloroquine notably attenuated the anti-inflammatory effect of A20, leading to the activation of the NF-\u03baB signaling pathway. In summary, the study demonstrated that A20\u2019s suppression of inflammation in LPS-stimulated BEECs is associated with the activation of autophagy. Therefore, the A20 protein showed potential as a novel treatment focus for managing endometritis in dairy cows.<\/jats:p>","DOI":"10.3390\/ani14192876","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T07:08:18Z","timestamp":1728284898000},"page":"2876","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A20 Alleviates the Inflammatory Response in Bovine Endometrial Epithelial Cells by Promoting Autophagy"],"prefix":"10.3390","volume":"14","author":[{"given":"Junsheng","family":"Dong","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education, Yangzhou 225009, China"},{"name":"International 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HMGB1\/NF-\u03baB Activation in bEECs","volume":"44","author":"Liu","year":"2021","journal-title":"Inflammation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.3168\/jds.2018-15595","article-title":"A model of clinical endometritis in Holstein heifers using pathogenic Escherichia coli and Trueperella pyogenes","volume":"102","author":"Piersanti","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev-animal-020518-115227","article-title":"Tolerance and Innate Immunity Shape the Development of Postpartum Uterine Disease and the Impact of Endometritis in Dairy Cattle","volume":"7","author":"Sheldon","year":"2019","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Wu, Y., Chen, J., Sun, Y., Dong, X., Wang, Z., Chen, J., and Dong, G. (2020). PGN and LTA from Staphylococcus aureus Induced Inflammation and Decreased Lactation through Regulating DNA Methylation and Histone H3 Acetylation in Bovine Mammary Epithelial Cells. Toxins, 12.","DOI":"10.3390\/toxins12040238"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.14202\/vetworld.2017.1529-1532","article-title":"Insights into bovine endometritis with special reference to phytotherapy","volume":"10","author":"Mandhwani","year":"2017","journal-title":"Vet. World"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"106912","DOI":"10.1016\/j.intimp.2020.106912","article-title":"MiR-505 as an anti-inflammatory regulator suppresses HMGB1\/NF-\u03baB pathway in lipopolysaccharide-mediated endometritis by targeting HMGB1","volume":"88","author":"Liu","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e13676","DOI":"10.14814\/phy2.13676","article-title":"Regulation of inflammatory mediator expression in bovine endometrial cells: Effects of lipopolysaccharide, interleukin 1 beta, and tumor necrosis factor alpha","volume":"6","author":"Koh","year":"2018","journal-title":"Physiol. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.theriogenology.2021.03.012","article-title":"Analysis of miRNA expression changes in bovine endometrial stromal cells treated with lipopolysaccharide","volume":"167","author":"Yan","year":"2021","journal-title":"Theriogenology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jid.2018.06.191","article-title":"Keratinocyte Expression of A20\/TNFAIP3 Controls Skin Inflammation Associated with Atopic Dermatitis and Psoriasis","volume":"139","author":"Devos","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1126\/science.1182364","article-title":"Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes","volume":"327","author":"Shembade","year":"2010","journal-title":"Science"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Liu, Y., Xu, K., Yao, Y., and Liu, Z. (2023). Current research into A20 mediation of allergic respiratory diseases and its potential usefulness as a therapeutic target. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1166928"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"103914","DOI":"10.1016\/j.cellimm.2019.04.002","article-title":"A20: A multifunctional tool for regulating immunity and preventing disease","volume":"340","author":"Malynn","year":"2019","journal-title":"Cell. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.immuni.2014.12.031","article-title":"A20 restricts ubiquitination of pro-interleukin-1\u03b2 protein complexes and suppresses NLRP3 inflammasome activity","volume":"42","author":"Duong","year":"2015","journal-title":"Immunity"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Han, X., Xu, T., Fang, Q., Zhang, H., Yue, L., Hu, G., and Sun, L. (2021). Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy. Redox. Biol., 44.","DOI":"10.1016\/j.redox.2021.102010"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s00018-022-04139-y","article-title":"A20 undermines alternative NF-\u03baB activity and expression of anti-apoptotic genes in Helicobacter pylori infection","volume":"79","author":"Lim","year":"2022","journal-title":"Cell. Mol. Life. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/15548627.2019.1628536","article-title":"Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation","volume":"16","author":"Wu","year":"2020","journal-title":"Autophagy"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nri.2016.100","article-title":"Crosstalk between autophagy and inflammatory signalling pathways: Balancing defence and homeostasis","volume":"16","author":"Cadwell","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10753-020-01324-8","article-title":"Focus on the Multimodal Role of Autophagy in Rheumatoid Arthritis","volume":"44","author":"Chadha","year":"2021","journal-title":"Inflammation"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ebiom.2017.06.012","article-title":"The NOD2-Smoking Interaction in Crohn\u2019s Disease is likely Specific to the 1007fs Mutation and may be Explained by Age at Diagnosis: A Meta-Analysis and Case-Only Study","volume":"21","author":"Kuenzig","year":"2017","journal-title":"eBioMedicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.crohns.2012.08.009","article-title":"Impaired autophagy leads to abnormal dendritic cell-epithelial cell interactions","volume":"7","author":"Strisciuglio","year":"2013","journal-title":"J. Crohns. Colitis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1080\/15548627.2018.1458804","article-title":"TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytes","volume":"14","author":"Zhai","year":"2018","journal-title":"Autophagy"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.theriogenology.2018.09.013","article-title":"The influence of experimentally induced endometritis on the PPAR expression profile in the bovine endometrium","volume":"122","author":"Socha","year":"2018","journal-title":"Theriogenology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e13820","DOI":"10.1111\/aji.13820","article-title":"Autophagy activation alleviates the LPS-induced inflammatory response in endometrial epithelial cells in dairy cows","volume":"91","author":"Dong","year":"2024","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1210\/en.2008-1379","article-title":"Bacterial lipopolysaccharide induces an endocrine switch from prostaglandin F2alpha to prostaglandin E2 in bovine endometrium","volume":"150","author":"Herath","year":"2009","journal-title":"Endocrinology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.gene.2016.01.030","article-title":"Characterization of bovine A20 gene: Expression mediated by NF-\u03baB pathway in MDBK cells infected with bovine viral diarrhea virus-1","volume":"581","author":"Fredericksen","year":"2016","journal-title":"Gene"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.3168\/jds.2022-22846","article-title":"Induced endometritis in early lactation compromises production and reproduction in dairy cows","volume":"106","author":"Husnain","year":"2023","journal-title":"J. Dairy. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.theriogenology.2020.01.017","article-title":"Preventing postpartum uterine disease in dairy cattle depends on avoiding, tolerating and resisting pathogenic bacteria","volume":"150","author":"Sheldon","year":"2020","journal-title":"Theriogenology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"107668","DOI":"10.1016\/j.intimp.2021.107668","article-title":"MicroRNA-211 regulates the expression of TAB1 and inhibits the NF-\u03baB signaling pathway in lipopolysaccharide-induced endometritis","volume":"96","author":"Yang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Li, Y., Mooney, E.C., Xia, X.J., Gupta, N., and Sahingur, S.E. (2020). A20 Restricts Inflammatory Response and Desensitizes Gingival Keratinocytes to Apoptosis. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00365"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1038\/s41467-022-33767-y","article-title":"Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1165\/rcmb.2010-0339TR","article-title":"A20 regulation of nuclear factor-\u03baB: Perspectives for inflammatory lung disease","volume":"44","author":"Kelly","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: Mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1126\/science.289.5488.2350","article-title":"Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice","volume":"289","author":"Lee","year":"2000","journal-title":"Science"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/15548627.2015.1071759","article-title":"Modulation of inflammation by autophagy: Consequences for human disease","volume":"12","author":"Plantinga","year":"2016","journal-title":"Autophagy"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41419-023-06154-8","article-title":"Autophagy: Regulator of cell death","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","article-title":"Biological Functions of Autophagy Genes: A Disease Perspective","volume":"176","author":"Levine","year":"2019","journal-title":"Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ebiom.2018.08.035","article-title":"Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-\u03baB pathway quenches intestinal inflammation and oxidative stress injury","volume":"35","author":"Zhou","year":"2018","journal-title":"eBioMedicine"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Liu, J., Qiu, R., Liu, R., Song, P., Lin, P., Chen, H., Zhou, D., Wang, A., and Jin, Y. (2022). Autophagy Mediates Escherichia coli-Induced Cellular Inflammatory Injury by Regulating Calcium Mobilization, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232214174"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Silwal, P., Paik, S., Kim, J.K., Yoshimori, T., and Jo, E.K. (2021). Regulatory Mechanisms of Autophagy-Targeted Antimicrobial Therapeutics Against Mycobacterial Infection. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.633360"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1080\/21505594.2020.1739411","article-title":"Streptococcus pneumoniae PepO promotes host anti-infection defense via autophagy in a Toll-like receptor 2\/4 dependent manner","volume":"11","author":"Shu","year":"2020","journal-title":"Virulence"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e0025222","DOI":"10.1128\/iai.00252-22","article-title":"Butyrate Ameliorates Intraocular Bacterial Infection by Promoting Autophagy and Attenuating the Inflammatory Response","volume":"91","author":"Singh","year":"2023","journal-title":"Infect. Immun."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Han, F., Wang, L., Shen, L., Liu, W., Li, Y., Ma, H., and Wu, X. (2023). A20 ameliorates Aspergillus fumigatus keratitis by promoting autophagy and inhibiting NF-\u03baB signaling. Int. J. Biol. Macromol., 253.","DOI":"10.1016\/j.ijbiomac.2023.127640"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbrc.2021.02.115","article-title":"A20 regulates inflammation through autophagy mediated by NF-\u03baB pathway in human nucleus pulposus cells and ameliorates disc degeneration in vivo","volume":"549","author":"Zhang","year":"2021","journal-title":"Biochem. Biophys. Res. 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