{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:58:34Z","timestamp":1781881114851,"version":"3.54.5"},"reference-count":89,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Insulinomas are the most common neoplasms of the endocrine pancreas in dogs, leading to persistent hypoglycemia due to inappropriate insulin secretion. The standard treatment is surgical resection, but it carries significant risks, including pancreatitis and diabetes mellitus. This study investigates the efficacy and safety of percutaneous ultrasound-guided radiofrequency ablation (RFA) as an alternative to surgery. A total of 29 dogs diagnosed with insulinoma were treated with RFA, targeting both primary pancreatic tumors and metastases in regional lymph nodes or the liver. Blood glucose levels and tumor size were monitored before and after the procedure. RFA led to a significant increase in blood glucose levels and a reduction in tumor size in all patients, with minimal postoperative complications. The results suggest that RFA is a feasible and effective treatment option for insulinomas in dogs.<\/jats:p>","DOI":"10.3390\/ani14223301","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T13:03:14Z","timestamp":1731934994000},"page":"3301","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Percutaneous Ultrasound-Guided Radiofrequency Ablation as a Therapeutic Approach for the Management of Insulinomas and Associated Metastases in Dogs"],"prefix":"10.3390","volume":"14","author":[{"given":"Mar\u00eda Dolores","family":"Alf\u00e9rez","sequence":"first","affiliation":[{"name":"VetCorner Unavets, 50012 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9771-4143","authenticated-orcid":false,"given":"Andrea","family":"Corda","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1204-4356","authenticated-orcid":false,"given":"Ignacio","family":"de Blas","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, University of Zaragoza, 50013 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-6120","authenticated-orcid":false,"given":"Lucas","family":"Gago","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Science, University of Barcelona, 08007 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Telmo","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Imaginologia Veterinaria do Porto, 4490-479 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Rodr\u00edguez-Piza","sequence":"additional","affiliation":[{"name":"Anicura Gl\u00f2ries Hospital Veterinari, 08010 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Bala\u00f1\u00e1","sequence":"additional","affiliation":[{"name":"Hospital Aralar Veterinarios, 50410 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-7969","authenticated-orcid":false,"given":"Francesca","family":"Corda","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9193-7661","authenticated-orcid":false,"given":"Pablo","family":"G\u00f3mez Ochoa","sequence":"additional","affiliation":[{"name":"VetCorner Unavets, 50012 Zaragoza, Spain"},{"name":"Department of Animal Pathology, University of Zaragoza, 50013 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5326\/JAAHA-MS-5745","article-title":"Insulinoma in dogs: A review","volume":"48","author":"Goutal","year":"2012","journal-title":"J. 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