{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:38:44Z","timestamp":1760146724403,"version":"build-2065373602"},"reference-count":101,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis University","doi-asserted-by":"publisher","award":["Start-up Grant No. CO-11725","RRF-2.3.1-21-2022-00010 \u2018National Laboratory of Virology\u2019"],"award-info":[{"award-number":["Start-up Grant No. CO-11725","RRF-2.3.1-21-2022-00010 \u2018National Laboratory of Virology\u2019"]}],"id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["Start-up Grant No. CO-11725","RRF-2.3.1-21-2022-00010 \u2018National Laboratory of Virology\u2019"],"award-info":[{"award-number":["Start-up Grant No. CO-11725","RRF-2.3.1-21-2022-00010 \u2018National Laboratory of Virology\u2019"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Adenovirus (AdV) infection has been rarely documented in cats and other felids. Partial sequences of the hexon and fiber genes of a Hungarian feline adenovirus isolate (FeAdV isolate) showed a close relationship to human AdV (HAdV) type C1. Further molecular and biological characterization is reported here. Whole-genome sequencing revealed two silent mutations in the genome of the FeAdV isolate compared to a HAdV-C1 reference strain (at positions 14,096 and 15,082). Competitive antibody binding to the Coxsackie\u2013adenovirus receptor and \u03b1v\u03b23 and \u03b1v\u03b25 integrin coreceptors inhibited the binding of the FeAdV isolate in different cell lines, but residual infections suggested alternative entry routes. The FeAdV isolate was found to be more sensitive to heat, low pH and detergents, but more resistant to alkaline and free chlorine treatments, as well as to ribavirin, stavudine and cidofovir treatments, than other human AdV types. We observed a suppression of IL-10 and TGF-\u03b21 production during the entire course of viral replication. This immunomodulation may restore intratumoral immunity; thus, the FeAdV isolate could serve as an alternative oncolytic vector. Collectively, our results support that the Hungarian FeAdV isolate is a variant of common HAdV-C1. The cohabitation of cats with humans might result in reverse zoonotic infection. Felids appear to be susceptible to persistent and productive adenovirus infection, but further studies are needed to better understand the clinical and epidemiological implications.<\/jats:p>","DOI":"10.3390\/ani14233502","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T04:47:22Z","timestamp":1733287642000},"page":"3502","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feline Adenovirus Isolate Shows Silent Nucleotide Alterations, Alternative Receptor\/Coreceptor Binding, High Resistance to Disinfectants and Antiviral Drugs, as Well as Immunomodulation"],"prefix":"10.3390","volume":"14","author":[{"given":"Katalin R\u00e9ka","family":"Tarcsai","sequence":"first","affiliation":[{"name":"Doctoral School, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kriszti\u00e1n","family":"B\u00e1nyai","sequence":"additional","affiliation":[{"name":"Pathogen Discovery Group, HUN-REN Veterinary Medical Research Institute, 1143 Budapest, Hungary"},{"name":"Department of Pharmacology and Toxicology, University of Veterinary Medicine, 1078 Budapest, Hungary"},{"name":"Szent\u00e1gothai Research Centre, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"},{"name":"Department of Laboratory Medicine, Medical School, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztina","family":"Bali","sequence":"additional","affiliation":[{"name":"Pathogen Discovery Group, HUN-REN Veterinary Medical Research Institute, 1143 Budapest, Hungary"},{"name":"Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, 1078 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Anoir","family":"Abbas","sequence":"additional","affiliation":[{"name":"Doctoral School, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria","family":"K\u00f6vesdi","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-2878","authenticated-orcid":false,"given":"J\u00f3zsef","family":"Ongr\u00e1di","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Department of Transfusion Medicine, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1002\/1873-3468.13696","article-title":"Innate immunity to adenovirus: Lessons from mice","volume":"593","author":"Atasheva","year":"2019","journal-title":"FEBS Lett."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1128\/CMR.00116-13","article-title":"Adenovirus infections in immunocompetent and immunocompromised patients","volume":"17","author":"Lion","year":"2014","journal-title":"Clin. 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