{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:38:35Z","timestamp":1790149115499,"version":"4.0.1"},"reference-count":31,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nutricorp"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This experiment evaluated the effects of bovine appeasing substance (BAS) administration at feedlot entry on growth, temperament, inflammation, response to vaccination, behavior, carcass characteristics, and meat quality of beef heifers. Thirty heifers were weaned and assigned to (d 0): (1) BAS (n = 15; SecureCattle; IRSEA Group) or (2) Saline (n = 15). On d 0, heifers were also vaccinated against respiratory diseases and slaughtered on d 150. Administering BAS increased (p = 0.05) average daily gain from d 6 to 45, reduced (p \u2264 0.03) plasma ceruloplasmin and serum cortisol concentrations on d 15 and 45 and increased (p = 0.03) the response to vaccination. Additionally, BAS reduced (p &lt; 0.01) the entry scores on d 6, 15, and 45 and reduced (p = 0.05) exit scores on d 2, 6, and 15. The BAS increased (p \u2264 0.04) walking, drinking, and eating time, and tended (p \u2264 0.10) to increase lying and ruminating time. Lastly, BAS tended (p \u2264 0.10) to increase the myofibrillar fragmentation index and reduce the thiobarbituric acid reactive substance concentration in meat. Thus, BAS administration increased growth, reduced stress, and inflammation, and improved immune responses, behavior, and meat quality of heifers.<\/jats:p>","DOI":"10.3390\/ani14233517","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T06:24:44Z","timestamp":1733379884000},"page":"3517","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Appeasing Substance Administration at Feedlot Entry Impacted Temperament, Pen Behavior, Immunocompetence, and Meat Quality of Beef Heifers"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7962-5155","authenticated-orcid":false,"given":"Douglas Gomes","family":"Vieira","sequence":"first","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade Federal de Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-6990","authenticated-orcid":false,"given":"Marcelo","family":"Vedovatto","sequence":"additional","affiliation":[{"name":"Dean Lee Research and Extension Center, Louisiana State University, Alexandria, LA 71302, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Fellipe","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Hill Farm Research Station, Louisiana State University, Homer, LA 71040, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-2577","authenticated-orcid":false,"given":"Juliana","family":"Ranches","sequence":"additional","affiliation":[{"name":"Eastern Oregon Agricultural Research Center, Oregon State University, Burns, OR 97720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Ieda","family":"Cappellozza","sequence":"additional","affiliation":[{"name":"Novonesis, 2970 H\u00f8rsholm, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-7012","authenticated-orcid":false,"given":"Osvaldo Alex","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Nutricorp, Araras 13601-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Canuto","sequence":"additional","affiliation":[{"name":"Unidade Universit\u00e1ria de Aquidauana, Universidade Estadual de Mato Grosso do Sul, Aquidauana 79200-000, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"de Nadai Bonin Gomes","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade Federal de Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7617-9711","authenticated-orcid":false,"given":"Henrique Jorge","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Unidade Universit\u00e1ria de Aquidauana, Universidade Estadual de Mato Grosso do Sul, Aquidauana 79200-000, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.2527\/jas.2006-501","article-title":"BOARD-INVITED REVIEW: Recent Advances in Management of Highly Stressed, Newly Received Feedlot Cattle","volume":"85","author":"Duff","year":"2007","journal-title":"J. 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