{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:40:54Z","timestamp":1760146854991,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Gastric lymphofollicular hyperplasia (GLFH) is characterized by large lymphoid nodules in the lamina propria. Its etiology and immunohistochemical characteristics are poorly understood. This study analyzed 41 canine GLFH cases, including clinical, endoscopic, histopathological, and immunohistochemical evaluations. Young French Bulldogs (75.06%) were the most affected. Endoscopically, lymphoid nodules were identified in both the antrum and gastric body. Lymphoid follicle diameters were similar in the gastric body (mean 295.587 \u03bcm) and antrum (mean 294.641 \u03bcm). Associated lesions included glandular atrophy, lymphoplasmacytic inflammation, and fibrosis. Minimal, moderate, and severe colonization with Helicobacter-like organisms (HLOs) were observed in 20, 6, and 3 cases, respectively. B-cell lymphocytes positive for Bcl6 and Pax5 were localized centrally in large follicles, surrounded by CD3+ T lymphocytes. Small follicles lacked germinal centers and showed mixed T and B lymphocytes. A positive correlation was found between the follicle diameter and both HLOs colonization (p = 0.049) and follicular hyperplasia (p &lt; 0.001). A regression analysis indicated that HLOs colonization and hyperplasia accounted for 42.3% of follicle diameter variance (R2 = 0.423, p &lt; 0.001). Additional studies are required to investigate potential correlations between GLFH and HLOs, as well as to assess the role of this lesion in the progression to neoplasia.<\/jats:p>","DOI":"10.3390\/ani14243605","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T09:17:58Z","timestamp":1734340678000},"page":"3605","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathological and Immunohistochemical Characterization of Follicular Gastritis (Gastric Lymphofollicular Hyperplasia) in 41 Dogs"],"prefix":"10.3390","volume":"14","author":[{"given":"Andrada","family":"Negoescu","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0455-1366","authenticated-orcid":false,"given":"Corina","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-9737","authenticated-orcid":false,"given":"Claudiu","family":"Gal","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"},{"name":"Department of Veterinary Pathology, Synevovet, 81 Pache Protopopescu, 021408 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"Ifteme","sequence":"additional","affiliation":[{"name":"Endoscopy and Minimal Invasive Surgery Veterinary Center, 077190 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Bofan","sequence":"additional","affiliation":[{"name":"Endoscopy and Minimal Invasive Surgery Veterinary Center, 077190 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-8549","authenticated-orcid":false,"given":"Teodoru","family":"Soare","sequence":"additional","affiliation":[{"name":"Histovet, 050855 Bucharest, Romania"},{"name":"Department of Pathology and Forensic Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Blvd., 011464 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-1631","authenticated-orcid":false,"given":"Irina","family":"Amorim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"},{"name":"Department of Pathology and Molecular Immunology of the Institute of Biomedical Sciences Abel Salazar, University of Porto, 4050-313 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1899-5977","authenticated-orcid":false,"given":"Raluca Maria","family":"Pop","sequence":"additional","affiliation":[{"name":"Pharmacology, Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, Victor Babe\u0219, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015etefan Cristian","family":"Vesa","sequence":"additional","affiliation":[{"name":"Pharmacology, Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, Victor Babe\u0219, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8268-288X","authenticated-orcid":false,"given":"Drago\u0219","family":"Hodor","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-5141","authenticated-orcid":false,"given":"Elvira","family":"Gagniuc","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Synevovet, 81 Pache Protopopescu, 021408 Bucharest, Romania"},{"name":"Department of Pathology and Forensic Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Blvd., 011464 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornel","family":"C\u0103toi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-6038","authenticated-orcid":false,"given":"Marian","family":"Taulescu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4102\/jsava.v74i3.515","article-title":"The Prevalence of Subclinical Gastroduodenal Ulceration in Dachshunds with Intervertebral Disc Prolapse","volume":"74","author":"Dowdle","year":"2003","journal-title":"J. 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