{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:57:22Z","timestamp":1772132242044,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health","award":["IZS PLV 13\/20 Ricerca Corrente"],"award-info":[{"award-number":["IZS PLV 13\/20 Ricerca Corrente"]}]},{"name":"Italian Ministry of Health","award":["IZS PLV 08\/22 Ricerca Corrente"],"award-info":[{"award-number":["IZS PLV 08\/22 Ricerca Corrente"]}]},{"name":"Italian Ministry of Health","award":["RRF-2.3.1-21-2022-00001"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00001"]}]},{"name":"National Laboratory for Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health, and Food Chain Safety","award":["IZS PLV 13\/20 Ricerca Corrente"],"award-info":[{"award-number":["IZS PLV 13\/20 Ricerca Corrente"]}]},{"name":"National Laboratory for Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health, and Food Chain Safety","award":["IZS PLV 08\/22 Ricerca Corrente"],"award-info":[{"award-number":["IZS PLV 08\/22 Ricerca Corrente"]}]},{"name":"National Laboratory for Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health, and Food Chain Safety","award":["RRF-2.3.1-21-2022-00001"],"award-info":[{"award-number":["RRF-2.3.1-21-2022-00001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>In 2022, a novel parvovirus was identified from an outbreak of fatal enteritis in weaned European hedgehogs (Erinaceus europaeus) at a wildlife rescue center in Southern Italy. During sequence analysis, the strain was found to be closely related (90.4% nucleotide identity) to a chaphamaparvovirus (ChPV) discovered in Amur hedgehogs (Erinaceus amurensis) during a large metaviromic investigation in game animals in China. In this study, we investigated the presence of this novel ChPV in necropsied European hedgehogs from different areas of North-Western Italy. Duodenal and liver samples collected from 194 necropsied hedgehogs were screened by using a specific quantitative PCR. A total of 38\/194 animals (19.6%) tested positive, with ChPV DNA being detected in the duodenum (9.3%, 18\/194), liver (7.2%, 14\/194) or in both (3.1%, 6\/194) tissue samples, with comparable rates and mean viral loads. The nearly full-length genome of four hedgehog ChPV strains was reconstructed. During phylogenetic analysis based on the NS1 and partial VP aa sequences, the four strains detected in this study tightly clustered with the prototype ChPVs previously identified in Amur and European hedgehogs within a potential novel candidate species of the genus Chaphamaparvovirus.<\/jats:p>","DOI":"10.3390\/ani14243624","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T09:17:58Z","timestamp":1734340678000},"page":"3624","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["European Hedgehogs as Hosts of Chaphamaparvovirus, Italy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7190-3835","authenticated-orcid":false,"given":"Federica","family":"Di Profio","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, Universit\u00e0 degli Studi di Teramo, Localit\u00e0 Piano D\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6192-7166","authenticated-orcid":false,"given":"Barbara","family":"Di Martino","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Universit\u00e0 degli Studi di Teramo, Localit\u00e0 Piano D\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4614-677X","authenticated-orcid":false,"given":"Gianvito","family":"Lanave","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Universit\u00e0 Aldo Moro di Bari, S.p. per Casamassima Km3, 70010 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-3425","authenticated-orcid":false,"given":"Serena","family":"Robetto","sequence":"additional","affiliation":[{"name":"Centro di Referenza Nazionale per le Malattie degli Animali Selvatici (CeRMAS), Istituto Zooprofilattico Sperimentale del Piemonte, della Liguria e della Valle d\u2019Aosta, 11020 Aosta, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6363-523X","authenticated-orcid":false,"given":"Ilaria","family":"Prandi","sequence":"additional","affiliation":[{"name":"Centro Animali Non Convenzionali (C.A.N.C), Department of Veterinary Sciences, University of Turin, 10095 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-0551","authenticated-orcid":false,"given":"Maria Teresa","family":"Capucchio","sequence":"additional","affiliation":[{"name":"Centro Animali Non Convenzionali (C.A.N.C), Department of Veterinary Sciences, University of Turin, 10095 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1296-6988","authenticated-orcid":false,"given":"Maria Lucia","family":"Mandola","sequence":"additional","affiliation":[{"name":"S.S. Virologia Specialistica, Istituto Zooprofilattico Sperimentale Piemonte, Liguria e Valle d\u2019Aosta, 10154 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8775-8401","authenticated-orcid":false,"given":"Giuseppe","family":"Quaranta","sequence":"additional","affiliation":[{"name":"Centro Animali Non Convenzionali (C.A.N.C), Department of Veterinary Sciences, University of Turin, 10095 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9027-1642","authenticated-orcid":false,"given":"Riccardo","family":"Orusa","sequence":"additional","affiliation":[{"name":"Centro di Referenza Nazionale per le Malattie degli Animali Selvatici (CeRMAS), Istituto Zooprofilattico Sperimentale del Piemonte, della Liguria e della Valle d\u2019Aosta, 11020 Aosta, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-1199","authenticated-orcid":false,"given":"Fulvio","family":"Marsilio","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Universit\u00e0 degli Studi di Teramo, Localit\u00e0 Piano D\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-6947","authenticated-orcid":false,"given":"Vito","family":"Martella","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Universit\u00e0 Aldo Moro di Bari, S.p. per Casamassima Km3, 70010 Bari, Italy"},{"name":"Department of Pharmacology and Toxicology, University of Veterinary Medicine, 1078 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2294-1624","authenticated-orcid":false,"given":"Vittorio","family":"Sarchese","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Universit\u00e0 degli Studi di Teramo, Localit\u00e0 Piano D\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03079458508436203","article-title":"Experimental infection of chicken embryos and day-old chickens with parvovirus of chicken origin","volume":"14","author":"Kisary","year":"1985","journal-title":"Avian Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"P\u00e9nzes, J.J., de Souza, W.M., Agbandje-McKenna, M., and Gifford, R.J. 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