{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:55:53Z","timestamp":1790477753080,"version":"4.1.0"},"reference-count":71,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011011","name":"Plan Andaluz de Investigacion","doi-asserted-by":"publisher","award":["AGR-277"],"award-info":[{"award-number":["AGR-277"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Cordoba (Spain)","award":["AGR-277"],"award-info":[{"award-number":["AGR-277"]}]},{"name":"Programa Operativo de Fondos FEDER Andalucia (Spain)","award":["AGR-277"],"award-info":[{"award-number":["AGR-277"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Systemic inflammatory response syndrome (SIRS) in donkeys is observed to be secondary to colic, diarrhea or pleuropneumonia, among other disorders. Horses with SIRS develop secondary disturbances such as hyperlipemia, laminitis, disseminated intravascular coagulopathy, and hemodynamic and cardiac derangements, which impair their prognosis and increase the mortality rate. In donkeys, no information is available on the effect of experimentally induced endotoxemia in the cardiovascular system. Acute experimental endotoxemia was induced by lipopolysaccharide (LPS) infusion in six healthy adult non-pregnant jennies. Physical signs, arterial (systolic, diastolic and mean) and central venous pressure were monitored during 360 min. Cardiac troponin I (cTnI) concentrations were measured in blood samples, and echocardiography was performed. LPS infusion caused an increase in cTnI, hypotension and diminution of central venous pressure, cardiac dysfunction, with a decrease in stroke volume (SV), cardiac output (CO) and cardiac index, and impairment of ultrasonographic ventricular function parameters. Intravenous meloxicam administration prevented the cTnI increase, hypotension, diminution of SV and CO, and changes in ultrasonographic parameters related to ventricular dysfunction. Thus, meloxicam could be proposed as an effective therapeutical option to control the hemodynamic and cardiac derangements observed in donkeys with SIRS.<\/jats:p>","DOI":"10.3390\/ani14243660","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T11:17:22Z","timestamp":1734520642000},"page":"3660","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hemodynamic Response to Lipopolysaccharide Infusion and Effect of Meloxicam Administration on Cardiac Function in Donkeys"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7725-8080","authenticated-orcid":false,"given":"Francisco J.","family":"Mendoza","sequence":"first","affiliation":[{"name":"Department of Animal Medicine and Surgery, University of Cordoba, 14014 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Buzon-Cuevas","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, University of Cordoba, 14014 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Aguilera-Aguilera","sequence":"additional","affiliation":[{"name":"Egabro Veterinary Center, Cabra, 14940 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Gonzalez-De Cara","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, University of Cordoba, 14014 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelaida","family":"De Las Heras","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, University of Cordoba, 14014 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-0940","authenticated-orcid":false,"given":"Alejandro","family":"Perez-Ecija","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, University of Cordoba, 14014 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mendoza, F.J., Toribio, R.E., and Perez-Ecija, A. (2024). Metabolic and endocrine insights in donkeys. Animals, 14.","DOI":"10.3390\/ani14040590"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jevs.2017.11.008","article-title":"The current situation and trend of donkey industry in Europe","volume":"65","author":"Camillo","year":"2018","journal-title":"J. Equine. Vet. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Costa, L.R.R., Aleman, M., and Davis, E. (2019). Comprehensive report of the caseload of donkeys and mules presented to a veterinary medical teaching hospital over a ten-year period. Animals, 9.","DOI":"10.3390\/ani9070413"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1939-1676.2011.0748.x","article-title":"Coagulation profiles of healthy Andalusian donkeys are different than those of healthy horses","volume":"25","author":"Mendoza","year":"2011","journal-title":"J. Vet. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/evj.12685","article-title":"Characterisation of clotting factors, anticoagulant protein activities and viscoelastic analysis in healthy donkeys","volume":"49","author":"Mendoza","year":"2017","journal-title":"Equine Vet. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cveq.2019.07.001","article-title":"Metabolic and endocrine disorders in donkeys","volume":"35","author":"Mendoza","year":"2019","journal-title":"Vet. Clin. N. Am. Equine Pract."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.2042-3306.2012.00622.x","article-title":"Thyroid hormone concentrations differ between donkeys and horses","volume":"45","author":"Mendoza","year":"2013","journal-title":"Equine Vet. J."},{"key":"ref_8","unstructured":"Reed, S.M., Bayly, W.M., and Sellon, D.C. (2018). Aspects of clinical relevance in donkeys. Equine Internal Medicine, Elsevier. [4th ed.]."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/eve.12290","article-title":"A review of equine sepsis","volume":"27","author":"Taylor","year":"2015","journal-title":"Equine Vet. Educ."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jevs.2018.02.001","article-title":"Donkey internal medicine\u2014Part I: Metabolic, endocrine, and alimentary tract disturbances","volume":"65","author":"Mendoza","year":"2018","journal-title":"J. Equine Vet. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jevs.2018.02.025","article-title":"Donkey Internal Medicine\u2014Part II: Cardiovascular, respiratory, neurologic, urinary, ophthalmic, dermatology, and musculoskeletal Disorders","volume":"65","author":"Mendoza","year":"2018","journal-title":"J. Equine Vet. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.cveq.2019.08.011","article-title":"Clinical pharmacology in donkeys and mules","volume":"35","author":"Mendoza","year":"2019","journal-title":"Vet. Clin. N. Am. Equine Pract."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1751-0813.2005.tb12191.x","article-title":"Equine endotoxaemia\u2014A state-of-the-art review of therapy","volume":"83","author":"Sykes","year":"2005","journal-title":"Aust. Vet. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cveq.2009.04.012","article-title":"Update on treatments for endotoxemia","volume":"25","author":"Kelmer","year":"2009","journal-title":"Vet. Clin. N. Am. Equine Pract."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.2042-3306.2012.00574.x","article-title":"Pattern recognition receptors in equine endotoxaemia and sepsis","volume":"44","author":"Werners","year":"2012","journal-title":"Equine Vet. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.17221\/133\/2016-VETMED","article-title":"The influence of experimentally-induced endotoxaemia on clinical variables and markers of systemic inflammation in donkeys (Equus asinus)","volume":"62","author":"Aamer","year":"2017","journal-title":"Vet. Med. Czech"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"102788","DOI":"10.1016\/j.jevs.2019.102788","article-title":"Comparative anti-inflammatory effects of insulin and flunixin on acute-phase responses and cardiovascular biomarkers during inflammatory phase in miniature donkeys","volume":"81","author":"Samimi","year":"2019","journal-title":"J. Equine Vet. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1111\/jvim.15783","article-title":"Meloxicam ameliorates the systemic inflammatory response syndrome associated with experimentally induced endotoxemia in adult donkeys","volume":"34","year":"2020","journal-title":"J. Vet. Intern. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Perez-Ecija, A., Buzon-Cuevas, A., Aguilera-Aguilera, R., Gonzalez-De Cara, C.A., and Mendoza, F.J. (2020). Blood storage conditions affect hematological analysis in samples from healthy donkeys and donkeys with experimentally-induced endotoxemia. Front. Vet. Sci., 7.","DOI":"10.3389\/fvets.2020.00640"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/jvim.16015","article-title":"Reference intervals of acute phase proteins in healthy Andalusian donkeys and response to experimentally induced endotoxemia","volume":"35","year":"2021","journal-title":"J. Vet. Intern. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.tvjl.2011.05.013","article-title":"Cardiac troponin I and the occurrence of cardiac arrhythmias in horses with experimentally induced endotoxaemia","volume":"192","author":"Nostell","year":"2012","journal-title":"Vet. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1111\/j.1939-1676.2006.tb00761.x","article-title":"Cardiovascular and pulmonary effects of Hetastarch plus hypertonic saline solutions during experimental endotoxemia in anesthetized horses","volume":"20","author":"Pantaleon","year":"2006","journal-title":"J. Vet. Intern. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/evj.13513","article-title":"Cardiopulmonary function and intestinal blood flow in anaesthetised, experimentally endotoxaemic horses given a constant rate infusion of dexmedetomidine","volume":"54","author":"Hector","year":"2021","journal-title":"Equine Vet. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9713326","DOI":"10.1155\/2022\/9713326","article-title":"High-sensitivity troponin: A review on characteristics, assessment, and clinical implications","volume":"2022","author":"Lazar","year":"2022","journal-title":"Dis. Markers"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.2460\/ajvr.1997.58.11.1300","article-title":"Effects of pentoxifylline infusion on response of horses to in vivo challenge exposure with endotoxin","volume":"58","author":"Barton","year":"1997","journal-title":"Am. J. Vet. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2746\/0425164044868350","article-title":"Polymyxin B protects horses against induced endotoxaemia in vivo","volume":"36","author":"Barton","year":"2004","journal-title":"Equine Vet. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.2042-3306.2012.00634.x","article-title":"Ethyl pyruvate diminishes the inflammatory response to lipopolysaccharide infusion in horses","volume":"45","author":"Jacobs","year":"2013","journal-title":"Equine Vet. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/jvim.16663","article-title":"Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia","volume":"37","author":"Mercer","year":"2023","journal-title":"J. Vet. Intern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"104205","DOI":"10.1016\/j.jevs.2022.104205","article-title":"Oral Administration of meloxicam and flunixin meglumine have similar analgesic effects after lipopolysaccharide-induced inflammatory response in Thoroughbred horses","volume":"121","author":"Urayama","year":"2023","journal-title":"J. Equine Vet. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.2460\/ajvr.67.6.1082","article-title":"Comparative pharmacokinetics of meloxicam in clinically normal horses and donkeys","volume":"67","author":"Sinclair","year":"2006","journal-title":"Am. J. Vet. Res."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Sheats, M.K. (2019). A comparative review of equine SIRS, sepsis, and neutrophils. Front. Vet. Sci., 6.","DOI":"10.3389\/fvets.2019.00069"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jvc.2010.01.002","article-title":"Assessment of left ventricular size and function in horses using anatomical M-mode echocardiography","volume":"12","author":"Grenacher","year":"2010","journal-title":"J. Vet. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.1939-1676.2010.0542.x","article-title":"Quantitative analysis of stress echocardiograms in healthy horses with 2-dimensional (2D) echocardiography, anatomical M-mode, tissue Doppler imaging, and 2D speckle tracking","volume":"24","author":"Schefer","year":"2010","journal-title":"J. Vet. Intern. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jevs.2015.01.016","article-title":"Two-dimensional and M-mode echocardiographic measurements in the healthy donkey (Equus asinus)","volume":"35","author":"Hassan","year":"2015","journal-title":"J. Equine Vet. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/vr.103734","article-title":"Echocardiographic reference ranges for sedentary donkeys in the UK","volume":"179","author":"Roberts","year":"2016","journal-title":"Vet. Rec."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0034-5288(91)90053-Q","article-title":"Effects of an infusion of dopamine on the cardiopulmonary effects of Escherichia coli endotoxin in anaesthetised horses","volume":"50","author":"Trim","year":"1991","journal-title":"Res. Vet. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/vcp.12006","article-title":"ASVCP reference interval guidelines: Determination of de novo reference intervals in veterinary species and other related topics","volume":"41","author":"Friedrichs","year":"2012","journal-title":"Vet. Clin. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Tharwat, M., and Al-Sobayil, F. (2014). Influence of the cardiac glycoside digoxin on cardiac troponin I, acid-base and electrolyte balance, and haematobiochemical profiles in healthy donkeys (Equus asinus). BMC Vet. Res., 10.","DOI":"10.1186\/1746-6148-10-64"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e445","DOI":"10.1111\/eve.13524","article-title":"Comparative anti-inflammatory effects of insulin and dexamethasone on cardiovascular biomarkers and antioxidants in miniature donkeys subjected to induced carbohydrate overload","volume":"34","author":"Samimi","year":"2022","journal-title":"Equine Vet. Educ."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/jamacardio.2023.4356","article-title":"High-sensitivity vs conventional troponin cutoffs for risk stratification in patients with acute pulmonary embolism","volume":"9","author":"Bikdeli","year":"2024","journal-title":"JAMA Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/1040638717747070","article-title":"Analytical validation of cardiac troponin I assays in horses","volume":"30","author":"Rossi","year":"2018","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00280-014-2544-3","article-title":"Modulatory effects of meloxicam on cardiotoxicity and antitumor activity of doxorubicin in mice","volume":"74","author":"Hassan","year":"2014","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00580-021-03261-w","article-title":"Comparative effects of meloxicam and dexamethasone in chickens with experimental systemic inflammation: Clinical outcome and cardiovascular parameters","volume":"30","author":"Nakhaee","year":"2021","journal-title":"Comp. Clin. Path"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1540-8183.2007.00336.x","article-title":"Increased troponin levels in nonischemic cardiac conditions and noncardiac diseases","volume":"21","author":"Brunetti","year":"2008","journal-title":"J. Interv. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2460\/ajvr.71.1.55","article-title":"Measurement of plasma cardiac troponin I concentration by use of a point-of-care analyzer in clinically normal horses and horses with experimentally induced cardiac disease","volume":"71","author":"Kraus","year":"2010","journal-title":"Am. J. Vet. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1532-950X.1995.tb01300.x","article-title":"Hemodynamic responses of horses to anesthesia and surgery, before and after administration of a low dose of endotoxin","volume":"24","author":"Wagner","year":"1995","journal-title":"Vet. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jevs.2011.01.011","article-title":"Echocardiographic assessment of left ventricular systolic function in colic horses","volume":"31","author":"Borde","year":"2011","journal-title":"J. Equine Vet. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.2042-3306.1981.tb04120.x","article-title":"Endotoxaemia in the horse","volume":"13","author":"Burrows","year":"1981","journal-title":"Equine Vet. J."},{"key":"ref_49","first-page":"999","article-title":"Thromboxane, prostaglandin I2 (epoprostenol), and the hemodynamic changes in equine endotoxin shock","volume":"43","author":"Bottoms","year":"1982","journal-title":"Am. J. Vet. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2746\/0425164044877260","article-title":"Endotoxin-induced digital vasoconstriction in horses: Associated changes in plasma concentrations of vasoconstrictor mediators","volume":"36","author":"Bailey","year":"2004","journal-title":"Equine Vet. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.rvsc.2013.01.003","article-title":"Effects of oral clenbuterol on the clinical and inflammatory response to endotoxaemia in the horse","volume":"94","author":"Cudmore","year":"2013","journal-title":"Res. Vet. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Pratt, S., Barnes, T.S., Cowling, N., de Klerk, K., Rainger, J., Sole-Guitart, A., Woldeyohannes, S., and Goodwin, W. (2022). Bias associated with peripheral non-invasive compared to invasive arterial blood pressure monitoring in healthy anaesthetised and standing horses using the Bionet BM7Vet. Vet. Sci., 9.","DOI":"10.3390\/vetsci9020052"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1939-1676.2005.tb02729.x","article-title":"Accuracy of indirect measurement of blood pressure in neonatal foals","volume":"19","author":"Giguere","year":"2005","journal-title":"J. Vet. Intern. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/jvim.13928","article-title":"Accuracy and precision of noninvasive blood pressure in normo-, hyper-, and hypotensive standing and anesthetized adult horses","volume":"30","author":"Heliczer","year":"2016","journal-title":"J. Vet. Intern. Med."},{"key":"ref_55","unstructured":"Matthews, N.S., and Taylor, T. (2004). Doppler echocardiographic reference values in healthy donkeys. Veterinary Care of Donkeys, International Veterinary Information Service."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/vr.103733","article-title":"Assessment of cardiovascular disease in the donkey: Clinical, echocardiographic and pathological observations","volume":"179","author":"Roberts","year":"2016","journal-title":"Vet. Rec."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jevs.2016.01.004","article-title":"Effects of tilmicosin phosphate administration on echocardiographic parameters in healthy donkeys (Equus asinus): An experimental study","volume":"38","author":"Youssef","year":"2016","journal-title":"J. Equine Vet. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"102929","DOI":"10.1016\/j.jevs.2020.102929","article-title":"Reference values and repeatability of B-Mode and M-Mode echocardiographic parameters in healthy donkey (Equus asinus)\u2014The guide to assess healthy heart","volume":"88","author":"Farag","year":"2020","journal-title":"J. Equine Vet. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Cruz-Aleixo, A.S., de Oliveira, K.C., de Oliveira Ferreira, L.V., Cedeo Quevedo, D.A., Cruz, R.K.S., Tsunemi, M.H., Chiacchio, S.B., and Louren\u00e7o, M.L.G. (2023). Electrocardiographic and echocardiographic parameters in Pega breed donkeys: A descriptive study. Animals, 13.","DOI":"10.3390\/ani13050861"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Marzok, M., Kandeel, M., Alkhodair, K., Abdel-Raheem, S., Ismail, H., Farag, A., Ibrahim, H., El-Ashkar, M., Shousha, S., and El-Khodery, S. (2023). Evaluation of cardiac indices using M-mode echocardiography after administration of metoclopramide and ondansetron in donkeys (Equus asinus): An experimental study. Front. Vet. Sci., 10.","DOI":"10.3389\/fvets.2023.1189710"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.2042-3306.1995.tb04985.x","article-title":"Echocardiographic measurements of cardiac dimensions and indices of cardiac function in normal adult thoroughbred horses","volume":"27","author":"Patteson","year":"1995","journal-title":"Equine Vet. J. Suppl."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.2042-3306.2002.tb05467.x","article-title":"Heart size estimated by echocardiography correlates with maximal oxygen uptake","volume":"34","author":"Young","year":"2002","journal-title":"Equine Vet. J. Suppl."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.rvsc.2013.02.014","article-title":"Effect of breed, sex, age and body weight on echocardiographic measurements in the Equine species","volume":"95","author":"Farnir","year":"2013","journal-title":"Res. Vet. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/vec.12177","article-title":"Prognostic value of echocardiographic and Doppler parameters in horses admitted for colic complicated by systemic inflammatory response syndrome","volume":"24","author":"Borde","year":"2014","journal-title":"J. Vet. Emerg. Crit. Care"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.2460\/javma.241.9.1202","article-title":"Clinicopathologic evidence of myocardial injury in horses with acute abdominal disease","volume":"241","author":"Nath","year":"2012","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/jvim.12034","article-title":"Doppler and volumetric echocardiographic methods for cardiac output measurement in standing adult horses","volume":"27","author":"McConachie","year":"2013","journal-title":"J. Vet. Intern. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2460\/ajvr.1997.58.11.1291","article-title":"Effect of pentoxifylline, flunixin meglumine, and their combination on a model of endotoxemia in horses","volume":"58","author":"Baskett","year":"1997","journal-title":"Am. J. Vet. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jevs.2019.03.001","article-title":"Oral Administration of meloxicam suppresses low-dose endotoxin challenge\u2013induced pain in Thoroughbred horses","volume":"77","author":"Urayama","year":"2019","journal-title":"J. Equine Vet. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/evj.12356","article-title":"Identifying behavioural differences in working donkeys in response to analgesic administration","volume":"48","author":"Regan","year":"2016","journal-title":"Equine Vet. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1751-0813.2002.tb14790.x","article-title":"Repeatability of standard transthoracic echocardiographic measurements in horses","volume":"80","author":"Kriz","year":"2002","journal-title":"Aust. Vet. J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.2042-3306.2011.00503.x","article-title":"Intraoperator, intraobserver and interoperator variability of echocardiographic measurements in healthy foals","volume":"44","author":"Slack","year":"2012","journal-title":"Equine Vet. 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