{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:17:48Z","timestamp":1790025468821,"version":"4.0.1"},"reference-count":90,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities","award":["202301BA070001-033"],"award-info":[{"award-number":["202301BA070001-033"]}]},{"name":"the Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities","award":["AG2024003"],"award-info":[{"award-number":["AG2024003"]}]},{"name":"the Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities","award":["KYBS2021063"],"award-info":[{"award-number":["KYBS2021063"]}]},{"name":"the Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities","award":["Yunfagaizi-23-11"],"award-info":[{"award-number":["Yunfagaizi-23-11"]}]},{"name":"the Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&amp;D","award":["202301BA070001-033"],"award-info":[{"award-number":["202301BA070001-033"]}]},{"name":"the Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&amp;D","award":["AG2024003"],"award-info":[{"award-number":["AG2024003"]}]},{"name":"the Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&amp;D","award":["KYBS2021063"],"award-info":[{"award-number":["KYBS2021063"]}]},{"name":"the Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&amp;D","award":["Yunfagaizi-23-11"],"award-info":[{"award-number":["Yunfagaizi-23-11"]}]},{"name":"Research and Development Fund Special Project of Dali University, the Yunnan Provincial Three Areas Science and Technology Talent Special Program of 2004-Li Huiying, the Scientific Startup Foundation for Doctors of Dali University","award":["202301BA070001-033"],"award-info":[{"award-number":["202301BA070001-033"]}]},{"name":"Research and Development Fund Special Project of Dali University, the Yunnan Provincial Three Areas Science and Technology Talent Special Program of 2004-Li Huiying, the Scientific Startup Foundation for Doctors of Dali University","award":["AG2024003"],"award-info":[{"award-number":["AG2024003"]}]},{"name":"Research and Development Fund Special Project of Dali University, the Yunnan Provincial Three Areas Science and Technology Talent Special Program of 2004-Li Huiying, the Scientific Startup Foundation for Doctors of Dali University","award":["KYBS2021063"],"award-info":[{"award-number":["KYBS2021063"]}]},{"name":"Research and Development Fund Special Project of Dali University, the Yunnan Provincial Three Areas Science and Technology Talent Special Program of 2004-Li Huiying, the Scientific Startup Foundation for Doctors of Dali University","award":["Yunfagaizi-23-11"],"award-info":[{"award-number":["Yunfagaizi-23-11"]}]},{"name":"Special sub project of Yunnan Provincial Development and Reform Commission","award":["202301BA070001-033"],"award-info":[{"award-number":["202301BA070001-033"]}]},{"name":"Special sub project of Yunnan Provincial Development and Reform Commission","award":["AG2024003"],"award-info":[{"award-number":["AG2024003"]}]},{"name":"Special sub project of Yunnan Provincial Development and Reform Commission","award":["KYBS2021063"],"award-info":[{"award-number":["KYBS2021063"]}]},{"name":"Special sub project of Yunnan Provincial Development and Reform Commission","award":["Yunfagaizi-23-11"],"award-info":[{"award-number":["Yunfagaizi-23-11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study investigated the effects of Periplaneta americana residue (PAR) on the immune function, antioxidant capacity, and transcriptome of Sanhuang chickens. Six hundred 30-day-old Sanhuang chickens were divided into six groups with diets of varying PAR replacement of soybean meal from 0 to 100% in increments of 20%. Samples were taken on day 100. The results indicated that PAR did not significantly affect growth performance (p &gt; 0.05). PAR significantly elevated the levels of IL-1\u03b2, IL-2, TNF-\u03b1, IgA, IgG, and IgM in both the serum and spleen (p &lt; 0.05). Moreover, it markedly increased the GSH-Px, T-AOC, SOD, and CAT levels in the serum and liver (p &lt; 0.05) and reached optimal levels of immune factors and antioxidant indicators at diet 2. Transcriptomic analysis revealed that substituting PAR for soybean meal downregulated genes associated with immune diseases and infectious disease pathways. Substituting soybean meal with PAR enhanced the resistance of Sanhuang chickens to pathogenic factors and oxidative stress, with no impact on growth performance. The optimal improvement was observed with diet 2.<\/jats:p>","DOI":"10.3390\/ani15010094","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T07:10:17Z","timestamp":1735888217000},"page":"94","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Periplaneta americana Residue Feed on Immunity, Antioxidant Capacity, and Transcriptome in Chickens: A Study on Sanhuang Chickens"],"prefix":"10.3390","volume":"15","author":[{"given":"Yongfei","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Agriculture and Biological Sciences, Dali University, Dali 671000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzhang","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biological Sciences, Dali University, Dali 671000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunyi","family":"Zi","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biological Sciences, Dali University, Dali 671000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyu","family":"Ou","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biological Sciences, Dali University, Dali 671000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Li","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biological Sciences, Dali University, Dali 671000, China"},{"name":"Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali 671000, China"},{"name":"National-Local Joint Engineering Research Center of Entomoceutics, Dali University, Dali 671000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"ref_1","first-page":"37","article-title":"Cockroach (Periplaneta americana): Nutritional value as food and feed for man and livestock","volume":"15","author":"Ukoroije","year":"2020","journal-title":"Asian Food Sci. 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