{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:50:11Z","timestamp":1782733811893,"version":"3.54.5"},"reference-count":40,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Background: The purpose of this study is to evaluate differences in transdiaphragmatic pressure (Pdi) in dogs suffering from cervical myelopathy (CM) and thoracolumbar myelopathy (TLM) anaesthetised with isoflurane (ISO). Methods: This prospective cohort study included ASA II-status dogs diagnosed with either CM or TLM, anaesthetised for diagnostic or surgical purposes between September 2021 and July 2023. Patients followed the same anaesthetic protocol, and maximum Pdi was recorded at 10 (Pdimax10), 20 (Pdimax20), and 30 (Pdimax30) minutes using balloon catheters placed in the stomach (Pgast) and in the mid-third of the oesophagus (Poes). Results: A total of 50 dogs were included: 25 in the CM group and 25 in the TLM group. In the TLM group, Pdimax10 was 9.4 mmHg \u00b1 6.1, and in the CM group, it was 7.2 mmHg \u00b1 4.6 (p = 0.167). Pdimax20 was 10.2 mmHg \u00b1 5.8 in the TLM group and 8 mmHg \u00b1 5.1 in the CM group (p = 0.155). Pdimax30 was 9.2 mmHg \u00b1 5.5 in the TLM group and 8.1 mmHg \u00b1 5.5 in the CM group (p = 0.479). Conclusions: The findings suggest that diaphragmatic contractility is similar in dogs with CM and TLM under ISO anaesthesia.<\/jats:p>","DOI":"10.3390\/ani15020147","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:17:08Z","timestamp":1736399828000},"page":"147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differences in Transdiaphragmatic Pressure of Dogs Suffering from Cervical or Thoracolumbar Myelopathy Anaesthetised with Isoflurane"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8703-6994","authenticated-orcid":false,"given":"Eirini","family":"Sarpekidou","sequence":"first","affiliation":[{"name":"Surgery & Obstetrics Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-3811","authenticated-orcid":false,"given":"Kyriaki","family":"Pavlidou","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5575-7244","authenticated-orcid":false,"given":"Ioannis","family":"Savvas","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4039-2398","authenticated-orcid":false,"given":"Zoe","family":"Polizopoulou","sequence":"additional","affiliation":[{"name":"Diagnostic Laboratory, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6678-2824","authenticated-orcid":false,"given":"George","family":"Kazakos","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"ref_1","unstructured":"Evans, H., and de Lahunta, A. (2013). Miller\u2019s Anatomy of the Dog, Elsevier. [4th ed.]."},{"key":"ref_2","unstructured":"Silverstein, D.C., and Hopper, K. (2009). Small Animal Critical Care Medicine, Saunders Elsevier."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1152\/japplphysiol.00960.2009","article-title":"Diagrammatic analysis of the respiratory action of the diaphragm","volume":"108","author":"Wilson","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1371\/journal.pone.0075341","article-title":"The Effect of Four Anaesthetic Protocols for Maintenance of Anaesthesia on Trans-Diaphragmatic Pressure in Dogs","volume":"8","author":"Pavlidou","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_5","unstructured":"de Lahunta, A., and Glass Eric, K.M. (2020). Veterinary Neuroanatomy and Clinical Neurology, Elsevier Inc.. [5th ed.]."},{"key":"ref_6","unstructured":"Dewey, W.C., and da Costa, C.R. (2016). Practical Guide to Canine and Feline Neurology, John Wiley & Sons."},{"key":"ref_7","unstructured":"Skerritt, G. (2022). Book King\u2019s Applied Anatomy of the Central Nervous System of Domestic Mammals, John Wiley & Sons Ltd.. [2nd ed.]."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Grimm, K.A., Lamont, L.A., Tranquilli, W.J., Greene, S.A., and Robertson, S.A. (2015). Veterinary Anesthesia and Analgesia the Fifth Edition of Lumb and Jones, John and Wiley & Sons, Inc.","DOI":"10.1002\/9781119421375"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.2460\/javma.2001.218.1598","article-title":"Ventilatory failure, ventilator management, and outcome in dogs with cervical spinal disorders: 14 cases (1991\u20131999)","volume":"218","author":"Beal","year":"2001","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_10","unstructured":"Sharp, N.J., and Wheeler, S.J. (2005). Small Animal Spinal Disorders, Elsevier Ltd.. [2nd ed.]."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1939-1676.2010.0661.x","article-title":"Neurological Cause s of Diaphr agmatic Paralysis in 11 Alpacas (Vicugna pacos)","volume":"25","author":"Byers","year":"2011","journal-title":"J. Vet. Intern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Galeiras V\u00e1zquez, R., Rascado Sedes, P., Mourelo Fari\u00f1a, M., Montoto Marqu\u00e9s, A., and Ferreiro Velasco, M.E. (2013). Respiratory management in the patient with spinal cord injury. Biomed Res. Int., 2013.","DOI":"10.1155\/2013\/168757"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0014-4886(86)90206-2","article-title":"Effect of cervical spinal cord hemisection and hemidiaphragm paralysis on arterial blood gases, pH, and respiratory rate in the adult rat","volume":"93","author":"Goshgarian","year":"1986","journal-title":"Exp. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.nbd.2005.12.019","article-title":"A new model of upper cervical spinal contusion inducing a persistent unilateral diaphragmatic deficit in the adult rat","volume":"22","author":"Baussart","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1152\/japplphysiol.00960.2005","article-title":"Recovery of phrenic activity and ventilation after cervical spinal hemisection in rats","volume":"100","author":"Fuller","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.2460\/javma.2000.216.1104","article-title":"Risk factors affecting the outcome of surgery for atlantoaxial subluxation in dogs: 46 cases (1978\u20131998)","volume":"216","author":"Beaver","year":"2000","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.5326\/15473317-35-2-135","article-title":"Cervical Vertebral Fractures in 56 Dogs: A Retrospective Study","volume":"35","author":"Hawthorne","year":"1999","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1152\/jappl.1994.77.4.1705","article-title":"Use of twitch pressures to assess diaphragmatic function and central drive","volume":"77","author":"Ferguson","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1183\/09031936.02.00302702","article-title":"Postprandial effects on twitch transdiaphragmatic pressure","volume":"20","author":"Man","year":"2002","journal-title":"Eur. Respir. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1183\/20734735.012616","article-title":"Respiratory problems and management in people with spinal cord injury","volume":"12","author":"Berlowitz","year":"2016","journal-title":"Breathe"},{"key":"ref_21","first-page":"853","article-title":"Respiratory Dysfunction and Management in Spinal Cord Injury","volume":"51","author":"Brown","year":"2006","journal-title":"Respir. Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1097\/01.ta.0000196005.49422.e6","article-title":"Respiratory complications and mortality risk associated with thoracic spine injury","volume":"59","author":"Cotton","year":"2005","journal-title":"J. Trauma\u2014Inj. Infect. Crit. Care"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Andruzzi, M.N., Simon, B.T., and Boudreau, E. (2021). Subclinical Hypoventilation in Dogs Undergoing Ventral Slot Decompressive Surgery for Cervical Myelopathy Due to Intervertebral Disc Herniation. Front. Vet. Sci., 8.","DOI":"10.3389\/fvets.2021.777052"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e3603","DOI":"10.1002\/vetr.3603","article-title":"Respiratory compromise in French bulldogs presented with intervertebral disc extrusion","volume":"193","author":"Foster","year":"2023","journal-title":"Vet. Rec."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/vru.12833","article-title":"Diaphragmatic dysfunction in dogs with cervical spinal disorders before and after surgery using fluoroscopy, motion-mode ultrasound and radiography was not different than a group of control dogs","volume":"61","author":"Drury","year":"2020","journal-title":"Vet. Radiol. Ultrasound"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"513","DOI":"10.5326\/0390513","article-title":"Severe Respiratory Compromise Secondary to Cervical Disk Herniation in Two Dogs","volume":"19","author":"Kube","year":"2003","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.prevetmed.2009.02.016","article-title":"Description and repeatability of a newly developed spinal cord injury scale for dogs","volume":"89","author":"Levine","year":"2009","journal-title":"Prev. Vet. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2460\/javma.235.3.281","article-title":"Incidence of and risk factors for postoperative pneumonia in dogs anesthetized for diagnosis or treatment of intervertebral disk disease","volume":"235","author":"Java","year":"2009","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_29","unstructured":"Garcia, E.R. (2018). BSAVA Manual of Canine and Feline Anaesthesia and Analgesia, British Small Animal Veterinary Association."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1939-1676.2002.tb02395.x","article-title":"Diaphragmatic Paralysis Due to Phrenic Nerve Degeneration in a Llama","volume":"16","author":"Bedenice","year":"2002","journal-title":"J. Vet. Intern. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1532-950X.2013.12039.x","article-title":"Acute adverse events associated with ventral slot decompression in 546 dogs with cervical intervertebral disc disease","volume":"42","author":"Rossmeisl","year":"2013","journal-title":"Vet. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3415\/vcot-17-05-0074","article-title":"Ventral Slot Surgery to Manage Cervical Intervertebral Disc Disease in Three Cats","volume":"31","author":"Crawford","year":"2018","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jfms.2007.03.009","article-title":"Acute non-ambulatory tetraparesis attributable to cranial cervical intervertebral disc disease in a cat","volume":"9","author":"Maritato","year":"2007","journal-title":"J. Feline Med. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1399-6576.1993.tb03710.x","article-title":"Diaphragmatic activity during isoflurane anaesthesia in dogs","volume":"37","author":"Ide","year":"1993","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/bja\/89.3.479","article-title":"Effects of halothane and isoflurane on the contraction, relaxation and energetics of rat diaphragmatic muscle","volume":"89","author":"Bouhemad","year":"2002","journal-title":"Br. J. Anaesth."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1378\/chest.130.3.827","article-title":"The effects of body mass index on lung volumes","volume":"130","author":"Jones","year":"2006","journal-title":"Chest"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.rmed.2017.01.004","article-title":"The effects of obesity on lung volumes and oxygenation","volume":"124","author":"Littleton","year":"2017","journal-title":"Respir. Med."},{"key":"ref_38","first-page":"190","article-title":"Association between the effects of body mass index on lung volumes among students in jiangsu province","volume":"25","author":"Musa","year":"2018","journal-title":"Pol. Ann. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.tvjl.2011.10.013","article-title":"Effects of obesity on lung function and airway reactivity in healthy dogs","volume":"193","author":"Manens","year":"2012","journal-title":"Vet. J."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Sarpekidou, E., Pavlidou, K., Savvas, I., Polizopoulou, Z., and Kazakos, G. (2024, January 18\u201321). Differences between transdiaphragmatic pressure of dogs suffering from cervical or thoracolumbar myelopathy anesthetized with isoflurane. Proceedings of the AVA Autumn Meeting, London, UK.","DOI":"10.1016\/j.vaa.2024.10.073"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/15\/2\/147\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:25:27Z","timestamp":1759919127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/15\/2\/147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,9]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["ani15020147"],"URL":"https:\/\/doi.org\/10.3390\/ani15020147","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,9]]}}}