{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:58:15Z","timestamp":1787698695458,"version":"build-2784847793"},"reference-count":81,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union Horizon 2020 Research and Innovation Program","award":["773436"],"award-info":[{"award-number":["773436"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Poor health and increased susceptibility to infectious diseases are among the main sources of economic losses in the pig industry worldwide, and they also serve as indicators of compromised animal welfare. However, there is limited information on long-lasting biomarkers of poor health and common infections experienced by piglets early in life. Hair cortisol, dehydroepiandrosterone sulfate (DHEA(S)), and their ratio have been proposed as components of the mammalian stress response due to the activation of the hypothalamus\u2013pituitary\u2013adrenal axis and were investigated in this study using 30 batches of pigs from 16 farms. The research hypothesis was that batches of piglets experiencing clinical syndromes (as indicated by enteric, neurological, cutaneous, and locomotor scores) during suckling would exhibit a different pattern of resilience and allostatic load later in life compared to healthy ones. Hair from 25 gilts per batch were collected at either 3.5 or 9 months of age, and hormone extraction was subsequently performed. The farm of origin and the age of the animals significantly influenced hormone concentrations. Moreover, batches affected by enteric disease showed lower DHEA(S) levels (p &lt; 0.0001; 15.89 vs. 23.51 pg\/mg) and higher cortisol\/DHEA(S) ratio (p &lt; 0.0001; 82.83 vs. 55.02) than healthy batches. Similar results were observed in batches with a neurological syndrome (DHEA(S): p &lt; 0.0001; 12.91 vs. 19.43; cortisol\/DHEA(S) ratio: p &lt; 0.0001; 97.15 vs. 70.26 pg\/mg). These results suggest that pig hair biomarkers carry an intrinsic and temporally stable signal related to early life health status.<\/jats:p>","DOI":"10.3390\/ani15071032","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T04:33:43Z","timestamp":1743654823000},"page":"1032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hair Dehydroepiandrosterone Sulfate (DHEA(S)) and Cortisol\/DHEA(S) Ratio as Long-Lasting Biomarkers of Clinical Syndromes Exhibited by Piglets Early in Life"],"prefix":"10.3390","volume":"15","author":[{"given":"Annalisa","family":"Scollo","sequence":"first","affiliation":[{"name":"Department of Veterinary Sciences, University of Torino, 10095 Grugliasco, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-9577","authenticated-orcid":false,"given":"Alessio","family":"Cotticelli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Production, University of Napoli Federico II, 80137 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5154-4222","authenticated-orcid":false,"given":"Tanja","family":"Peric","sequence":"additional","affiliation":[{"name":"Department of Agricultural Food, Environmental and Animal Science (DI4A), University of Udine, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Perrucci","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Torino, 10095 Grugliasco, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Prandi","sequence":"additional","affiliation":[{"name":"Department of Agricultural Food, Environmental and Animal Science (DI4A), University of Udine, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-3443","authenticated-orcid":false,"given":"Paolo","family":"Ferrari","sequence":"additional","affiliation":[{"name":"CRPA Research Centre for Animal Production, 42121 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0301-6226(03)00039-3","article-title":"Benefit to cost of vaccination against Mycoplasma hyopneumoniae in pig herds under Belgian market conditions from 1996 to 2000","volume":"83","author":"Maes","year":"2003","journal-title":"Livest. 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