{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:20:32Z","timestamp":1787746832078,"version":"build-2784847793"},"reference-count":69,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022ZD0115704"],"award-info":[{"award-number":["2022ZD0115704"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Expression quantitative trait locus (eQTL) mapping is an effective tool for identifying genetic variations that regulate gene expression. An increasing number of studies suggested that SNPs associated with complex traits in farm animals are considered as expression quantitative trait loci. Identifying eQTLs associated with gene expression levels in the endometrium helps to unravel the regulatory mechanisms of genes related to reproductive functions in this tissue and provides molecular markers for the genetic improvement of high-fertility sow breeding. In this study, 218 RNA-seq data from pig endometrial tissue were used for eQTL analysis to identify genetic variants regulating gene expression. Additionally, weighted gene co-expression network analysis (WGCNA) was performed to identify hub genes involved in reproductive functions. The eQTL analysis identified 34,876 significant cis-eQTLs regulating the expression of 5632 genes (FDR \u2264 0.05), and 90 hub genes were identified by WGCNA analysis. By integrating eQTL and WGCNA results, 14 candidate genes and 16 fine-mapped cis-eQTLs were identified, including FRK, ARMC3, SLC35F3, TMEM72, FFAR4, SOWAHA, PSPH, FMO5, HPN, FUT2, RAP1GAP, C6orf52, SEL1L3, and CLGN, which were involved in the physiological processes of reproduction in sows through hormone regulation, cell adhesion, and amino acid and lipid metabolism. These eQTLs regulate the high expression of candidate genes in the endometrium, thereby affecting reproductive-related physiological functions. These findings enhance our understanding of the genetic basis of reproductive traits and provide valuable genetic markers for marker-assisted selection (MAS), which can be applied to improve sow fecundity and optimize breeding strategies for high reproductive performance.<\/jats:p>","DOI":"10.3390\/ani15071038","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T03:36:45Z","timestamp":1743737805000},"page":"1038","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of Candidate Genes and eQTLs Related to Porcine Reproductive Function"],"prefix":"10.3390","volume":"15","author":[{"given":"Tong","family":"Zeng","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Wang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhexi","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"},{"name":"Frontier Technology Research Institute of China Agricultural University in Shenzhen, Shenzhen 518119, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Municipal General Station for Animal Husbandry & Veterinary Service, Beijing 100107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-8118","authenticated-orcid":false,"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Ai","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Deng","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keliang","family":"Wu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"},{"name":"Sichuan Advanced Agricultural & Industrial Institute, China Agricultural University, Chengdu 611430, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Benjamin, M., and Yik, S. (2019). Precision Livestock Farming in Swine Welfare: A Review for Swine Practitioners. Animals, 9.","DOI":"10.3390\/ani9040133"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/mrd.23625","article-title":"Functional Genomics of Reproduction in Pigs: Are We There Yet?","volume":"90","author":"Nonneman","year":"2023","journal-title":"Mol. Reprod. Dev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/mrd.22875","article-title":"Genetic Control of Complex Traits, with a Focus on Reproduction in Pigs","volume":"84","author":"Zak","year":"2017","journal-title":"Mol. Reprod. Dev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.tvjl.2005.11.013","article-title":"Genetic Approaches to the Improvement of Fertility Traits in the Pig","volume":"172","author":"Distl","year":"2006","journal-title":"Vet. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101062","DOI":"10.1016\/j.animal.2023.101062","article-title":"Using Genomic Selection to Improve the Accuracy of Genomic Prediction for Multi-Populations in Pigs","volume":"18","author":"Yin","year":"2024","journal-title":"Animal"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"106656","DOI":"10.1016\/j.domaniend.2021.106656","article-title":"Pregnancy in Pigs: The Journey of an Early Life","volume":"78","author":"Almeida","year":"2022","journal-title":"Domest. Anim. Endocrinol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.theriogenology.2015.08.001","article-title":"Placentation, Maternal\u2013Fetal Interface, and Conceptus Loss in Swine","volume":"85","author":"Kridli","year":"2016","journal-title":"Theriogenology"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zhang, H., Liu, Z., Wang, J., Zeng, T., Ai, X., and Wu, K. (2023). An Integrative ATAC-Seq and RNA-Seq Analysis of the Endometrial Tissues of Meishan and Duroc Pigs. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914812"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Li, W.-T., Zhang, M.-M., Li, Q.-G., Tang, H., Zhang, L.-F., Wang, K.-J., Zhu, M.-Z., Lu, Y.-F., Bao, H.-G., and Zhang, Y.-M. (2017). Whole-Genome Resequencing Reveals Candidate Mutations for Pig Prolificacy. Proc. R. Soc. B Biol. Sci., 284.","DOI":"10.1098\/rspb.2017.2437"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Liu, Z., Xu, R., Zhang, H., Wang, D., Wang, J., and Wu, K. (2022). A Unique 15-Bp InDel in the First Intron of BMPR1B Regulates Its Expression in Taihu Pigs. BMC Genom., 23.","DOI":"10.1186\/s12864-022-08988-6"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Liu, Z., Zhang, H., Wang, J., Wang, D., Zeng, T., Ai, X., Wang, X., Zhao, X., and Wu, K. (2025). Functional Effects of BMPR1B in Porcine Endometrium Provides Novel Insights into the High Fecundity of Taihu Pigs. Int. J. Biol. Macromol., 293.","DOI":"10.1016\/j.ijbiomac.2024.139188"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Xing, L., Lu, X., Zhang, W., Wang, Q., and Zhang, W. (2024). Genetic Structure and Genome-Wide Association Analysis of Growth and Reproductive Traits in Fengjing Pigs. Animals, 14.","DOI":"10.3390\/ani14172449"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"100672","DOI":"10.1016\/j.animal.2022.100672","article-title":"Genome-Wide Association Studies Uncover Genes Associated with Litter Traits in the Pig","volume":"16","author":"Zhao","year":"2022","journal-title":"Animal"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Chen, Z., Ye, S., He, Y., Huang, S., Yuan, X., Chen, Z., Zhang, H., and Li, J. (2019). Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population. Animals, 9.","DOI":"10.3390\/ani9100732"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"R73","DOI":"10.1093\/hmg\/ddac198","article-title":"Demystifying Non-Coding GWAS Variants: An Overview of Computational Tools and Methods","volume":"31","author":"Schipper","year":"2022","journal-title":"Hum. Mol. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-biodatasci-122120-010010","article-title":"Functional Characterization of Genetic Variant Effects on Expression","volume":"5","author":"Flynn","year":"2022","journal-title":"Annu. Rev. Biomed. Data Sci."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Pai, A.A., Pritchard, J.K., and Gilad, Y. (2015). The Genetic and Mechanistic Basis for Variation in Gene Regulation. PLoS Genet., 11.","DOI":"10.1371\/journal.pgen.1004857"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Safaei, S.M.H., Dadpasand, M., Mohammadabadi, M., Atashi, H., Stavetska, R., Klopenko, N., and Kalashnyk, O. (2023). An Origanum majorana Leaf Diet Influences Myogenin Gene Expression, Performance, and Carcass Characteristics in Lambs. Animals, 13.","DOI":"10.3390\/ani13010014"},{"key":"ref_19","first-page":"6848","article-title":"Analysis of Bovine Growth Hormone Gene Polymorphism of Local and Holstein Cattle Breeds in Kerman Province of Iran Using Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP)","volume":"9","author":"Mohammadabadi","year":"2010","journal-title":"Afr. J. Biotechnol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Cai, W., Hu, J., Zhang, Y., Guo, Z., Zhou, Z., and Hou, S. (2024). Cis-eQTLs in Seven Duck Tissues Identify Novel Candidate Genes for Growth and Carcass Traits. BMC Genom., 25.","DOI":"10.1186\/s12864-024-10338-7"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Cai, W., Zhang, Y., Chang, T., Wang, Z., Zhu, B., Chen, Y., Gao, X., Xu, L., Zhang, L., and Gao, H. (2023). The eQTL Colocalization and Transcriptome-Wide Association Study Identify Potentially Causal Genes Responsible for Economic Traits in Simmental Beef Cattle. J. Anim. Sci. Biotechnol., 14.","DOI":"10.1186\/s40104-023-00876-7"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1152\/physiolgenomics.00125.2018","article-title":"Characterization of eQTLs Associated with Androstenone by RNA Sequencing in Porcine Testis","volume":"51","author":"Drag","year":"2019","journal-title":"Physiol. Genom."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"The GTEx Consortium, Aguet, F., Anand, S., Ardlie, K.G., Gabriel, S., Getz, G.A., Graubert, A., Hadley, K., Handsaker, R.E., and Huang, K.H. (2020). The GTEx Consortium Atlas of Genetic Regulatory Effects across Human Tissues. Science, 369, 1318\u20131330.","DOI":"10.1126\/science.aaz1776"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41588-023-01585-7","article-title":"A Compendium of Genetic Regulatory Effects across Pig Tissues","volume":"56","author":"Teng","year":"2024","journal-title":"Nat. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: A Flexible Trimmer for Illumina Sequence Data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast Universal RNA-Seq Aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie Enables Improved Reconstruction of a Transcriptome from RNA-Seq Reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: A MapReduce Framework for Analyzing next-Generation DNA Sequencing Data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-Generation PLINK: Rising to the Challenge of Larger and Richer Datasets","volume":"4","author":"Chang","year":"2015","journal-title":"GigaScience"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nprot.2011.457","article-title":"Using Probabilistic Estimation of Expression Residuals (PEER) to Obtain Increased Power and Interpretability of Gene Expression Analyses","volume":"7","author":"Stegle","year":"2012","journal-title":"Nat. Protoc."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Taylor-Weiner, A., Aguet, F., Haradhvala, N.J., Gosai, S., Anand, S., Kim, J., Ardlie, K., Van Allen, E.M., and Getz, G. (2019). Scaling Computational Genomics to Millions of Individuals with GPUs. Genome Biol., 20.","DOI":"10.1186\/s13059-019-1836-7"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"D956","DOI":"10.1093\/nar\/gkab1116","article-title":"Bringing the Animal QTLdb and CorrDB into the Future: Meeting New Challenges and Providing Updated Services","volume":"50","author":"Hu","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zhang, X., Jiang, W., and Zhao, H. (2024). Integration of Expression QTLs with Fine Mapping via SuSiE. PLoS Genet., 20.","DOI":"10.1371\/journal.pgen.1010929"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1101\/gr.216747.116","article-title":"Quantifying the Regulatory Effect Size of Cis-Acting Genetic Variation Using Allelic Fold Change","volume":"27","author":"Mohammadi","year":"2017","journal-title":"Genome Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Langfelder, P., and Horvath, S. (2008). WGCNA: An R Package for Weighted Correlation Network Analysis. BMC Bioinform., 9.","DOI":"10.1186\/1471-2105-9-559"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Xing, K., Liu, H., Zhang, F., Liu, Y., Shi, Y., Ding, X., and Wang, C. (2021). Identification of Key Genes Affecting Porcine Fat Deposition Based on Co-Expression Network Analysis of Weighted Genes. J. Anim. Sci. Biotechnol., 12.","DOI":"10.1186\/s40104-021-00616-9"},{"key":"ref_37","first-page":"100141","article-title":"clusterProfiler 4.0: A Universal Enrichment Tool for Interpreting Omics Data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Guan, D., Bai, Z., Zhu, X., Zhong, C., Hou, Y., Lan, F., Diao, S., Yao, Y., Zhao, B., and Zhu, D. (2023). The ChickenGTEx Pilot Analysis: A Reference of Regulatory Variants across 28 Chicken Tissues. bioRxiv.","DOI":"10.1101\/2023.06.27.546670"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Tang, Y., Zhang, J., Li, W., Liu, X., Chen, S., Mi, S., Yang, J., Teng, J., Fang, L., and Yu, Y. (2024). Identification and Characterization of Whole Blood Gene Expression and Splicing Quantitative Trait Loci during Early to Mid-Lactation of Dairy Cattle. BMC Genom., 25.","DOI":"10.1186\/s12864-024-10346-7"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Diniz, W.J.S., Afonso, J., Kertz, N.C., Dyce, P.W., and Banerjee, P. (2024). Mapping Expression Quantitative Trait Loci Targeting Candidate Genes for Pregnancy in Beef Cows. Biomolecules, 14.","DOI":"10.3390\/biom14020150"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41576-019-0127-1","article-title":"Benefits and Limitations of Genome-Wide Association Studies","volume":"20","author":"Tam","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s43586-022-00188-6","article-title":"Molecular Quantitative Trait Loci","volume":"3","author":"Aguet","year":"2023","journal-title":"Nat. Rev. Methods Primers"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-Scale Cis- and Trans-eQTL Analyses Identify Thousands of Genetic Loci and Polygenic Scores That Regulate Blood Gene Expression","volume":"53","author":"Claringbould","year":"2021","journal-title":"Nat. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41576-018-0016-z","article-title":"From Genome-Wide Associations to Candidate Causal Variants by Statistical Fine-Mapping","volume":"19","author":"Schaid","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kim, J.-M., Park, J.-E., Yoo, I., Han, J., Kim, N., Lim, W.-J., Cho, E.-S., Choi, B., Choi, S., and Kim, T.-H. (2018). Integrated Transcriptomes throughout Swine Oestrous Cycle Reveal Dynamic Changes in Reproductive Tissues Interacting Networks. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-23655-1"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Forde, N., Simintiras, C.A., Sturmey, R., Mamo, S., Kelly, A.K., Spencer, T.E., Bazer, F.W., and Lonergan, P. (2014). Amino Acids in the Uterine Luminal Fluid Reflects the Temporal Changes in Transporter Expression in the Endometrium and Conceptus during Early Pregnancy in Cattle. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0100010"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s12964-024-01763-y","article-title":"Metabolic Reprogramming and Heterogeneity during the Decidualization Process of Endometrial Stromal Cells","volume":"22","author":"Jia","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/humupd\/dmac026","article-title":"Lipid Metabolism and Endometrial Receptivity","volume":"28","author":"Yang","year":"2022","journal-title":"Hum. Reprod. Update"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Artimovi\u010d, P., Badovsk\u00e1, Z., Toporcerov\u00e1, S., \u0160pakov\u00e1, I., Smolko, L., Sabolov\u00e1, G., Kriv\u00e1kov\u00e1, E., and Rabajdov\u00e1, M. (2024). Oxidative Stress and the Nrf2\/PPAR\u03b3 Axis in the Endometrium: Insights into Female Fertility. Cells, 13.","DOI":"10.3390\/cells13131081"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1007\/s11033-022-08168-5","article-title":"Allelic to Genome Wide Perspectives of Swine Genetic Variation to Litter Size and Its Component Traits","volume":"50","author":"Vaishnav","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/molehr\/gar070","article-title":"Macrophages Regulate Expression of A1,2-Fucosyltransferase Genes in Human Endometrial Epithelial Cells","volume":"18","author":"Nakamura","year":"2012","journal-title":"Mol. Hum. Reprod."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Wu, Z., Feng, H., Cao, Y., Huang, Y., Dai, C., Wu, S., and Bao, W. (2018). New Insight into the Molecular Mechanism of the FUT2 Regulating Escherichia coli F18 Resistance in Weaned Piglets. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113301"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s13258-017-0623-7","article-title":"Association Analysis of the SNP (Rs345476947) in the FUT2 Gene with the Production and Reproductive Traits in Pigs","volume":"40","author":"Wang","year":"2018","journal-title":"Genes Genom."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.ebiom.2018.12.019","article-title":"Protective Role of GPR120 in the Maintenance of Pregnancy by Promoting Decidualization via Regulation of Glucose Metabolism","volume":"39","author":"Huang","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12031-014-0355-y","article-title":"FRK Inhibits Migration and Invasion of Human Glioma Cells by Promoting N-Cadherin\/\u03b2-Catenin Complex Formation","volume":"55","author":"Shi","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.bbrc.2017.02.044","article-title":"Rap1GAP Inhibits Tumor Progression in Endometrial Cancer","volume":"485","author":"Tamate","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/mrd.23312","article-title":"Adhesion Molecules in Gamete Transport, Fertilization, Early Embryonic Development, and Implantation\u2014Role in Establishing a Pregnancy in Cattle: A Review","volume":"87","author":"Campanile","year":"2020","journal-title":"Mol. Reprod. Dev."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Huang, Y., Jiang, Z., Gao, X., Luo, P., and Jiang, X. (2021). ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.791597"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Patir, A., Fraser, A.M., Barnett, M.W., McTeir, L., Rainger, J., Davey, M.G., and Freeman, T.C. (2020). The Transcriptional Signature Associated with Human Motile Cilia. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-66453-4"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrm.2017.21","article-title":"The Development and Functions of Multiciliated Epithelia","volume":"18","author":"Spassky","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/42484","article-title":"The Putative Chaperone Calmegin Is Required for Sperm Fertility","volume":"387","author":"Ikawa","year":"1997","journal-title":"Nature"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Zang, X.-L., Han, W.-Q., Yang, F.-P., Ji, K.-D., Wang, J.-G., Gao, P.-J., He, G., and Wu, S.-N. (2016). Association of a SNP in SLC35F3 Gene with the Risk of Hypertension in a Chinese Han Population. Front. Genet., 7.","DOI":"10.3389\/fgene.2016.00108"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ygcen.2015.03.003","article-title":"Estrogen Regulation of Phosphoserine Phosphatase during Regression and Recrudescence of Female Reproductive Organs","volume":"214","author":"Lee","year":"2015","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Uno, Y., Shimizu, M., Ogawa, Y., Makiguchi, M., Kawaguchi, H., Yamato, O., Ishizuka, M., and Yamazaki, H. (2022). Molecular and Functional Characterization of Flavin-Containing Monooxygenases in Pigs, Dogs, and Cats. Biochem. Pharmacol., 202.","DOI":"10.1016\/j.bcp.2022.115125"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1210\/jcem.82.9.4239","article-title":"Progesterone Regulated Expression of Flavin-Containing Monooxygenase 5 by the B-Isoform of Progesterone Receptors: Implications for Tamoxifen Carcinogenicity","volume":"82","author":"Miller","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_66","first-page":"1","article-title":"Integrated Transcriptomic Analysis on Small Yellow Follicles Reveals That Sosondowah Ankyrin Repeat Domain Family Member A Inhibits Chicken Follicle Selection","volume":"34","author":"Zhong","year":"2020","journal-title":"Anim. Biosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/1878-0261.13545","article-title":"Hepsin Promotes Breast Tumor Growth Signaling via the TGF\u03b2-EGFR Axis","volume":"18","author":"Munne","year":"2024","journal-title":"Mol. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1111\/febs.16697","article-title":"ER Export Signals Mediate Plasma Membrane Localization of Transmembrane Protein TMEM72","volume":"290","author":"Ding","year":"2023","journal-title":"FEBS J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1021\/acs.jproteome.2c00382","article-title":"Tissue Proteogenomic Landscape Reveals the Role of Uncharacterized SEL1L3 in Progression and Immunotherapy Response in Lung Adenocarcinoma","volume":"22","author":"Shen","year":"2023","journal-title":"J. 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