{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:43:14Z","timestamp":1785156194344,"version":"3.55.0"},"reference-count":40,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Royal Canin SAS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Feline atopic skin syndrome (FASS) is a common inflammatory and highly pruritic skin condition. It typically manifests according to one or more of four different clinical lesion patterns: miliary dermatitis, self-induced alopecia, head and neck pruritus, and eosinophilic granuloma complex. FASS is a chronic and relapsing condition that often persists for life. Effective management can be a significant challenge for both clinicians and owners. Here, we investigated whether diet could act as an adjunct to conventional medicated therapies to improve the management of FASS. We conducted a six-month randomised, placebo-controlled, double-blinded study on client-owned FASS cats to test a novel pet food formulation. The main variables followed were the veterinarian (FeDESI) and the owner (VAScat) assessing symptom severity, in addition to medication requirements. Compared to the control diet, the test diet not only ameliorated symptoms but also significantly reduced the dependency on medication. The VAScat metric was improved after 3 months (p = 1.6 \u00d7 10\u22124) and 6 months (p = 5.7 \u00d7 10\u22125) in the test group only, and the cats\u2019 medication requirement significantly declined exclusively in the test group from month 2 onwards. The interpretation of the FeDESI results was hampered by high levels of variation, particularly in the control group. Nonetheless, in the test group, clinical scores showed evidence of improvement after 3 months (p = 0.037) and 6 months (p = 0.02), and no such improvement was detected in the control group. Overall, our findings suggest that tailored nutrition can significantly aid in the management of feline atopic skin syndrome.<\/jats:p>","DOI":"10.3390\/ani15101429","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T04:39:16Z","timestamp":1747283956000},"page":"1429","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Randomised-Controlled Study Demonstrates That Diet Can Contribute to the Clinical Management of Feline Atopic Skin Syndrome (FASS)"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7623-0457","authenticated-orcid":false,"given":"Adrian","family":"Watson","sequence":"first","affiliation":[{"name":"Royal Canin SAS, 30740 Aimargues, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Laxalde","sequence":"additional","affiliation":[{"name":"Royal Canin SAS, 30740 Aimargues, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Br\u00e9ment","sequence":"additional","affiliation":[{"name":"Veterinary Dermatology Referral Service EIRL Vet\u2019Dermathome, 83190 Ollioules, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie Vid\u00e9mont","family":"Drevon-Gaillot","sequence":"additional","affiliation":[{"name":"Centre Hospitalier V\u00e9t\u00e9rinaire Saint-Martin, 321 Impasse des Champs, 74350 Allonzier la Caille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-2452","authenticated-orcid":false,"given":"Marion","family":"Mosca","sequence":"additional","affiliation":[{"name":"VetAgro Sup, Interactions Cells Environment, UPSP 2016.A104, Universit\u00e9 de Lyon, 69280 Marcy L\u2019\u00e9toile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8255-0563","authenticated-orcid":false,"given":"Elisa","family":"Maina","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine, Clinical Dermatology, Vetsuisse Faculty, University of Bern, CH-3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Langon","sequence":"additional","affiliation":[{"name":"Royal Canin SAS, 30740 Aimargues, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8-e2","DOI":"10.1111\/vde.12899","article-title":"Feline allergic diseases: Introduction and proposed nomenclature","volume":"32","author":"Halliwell","year":"2021","journal-title":"Vet. 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