{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:05:03Z","timestamp":1785287103450,"version":"3.55.0"},"reference-count":32,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Veterinary Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>In 2021, a captive two-year-old African elephant died of cardiovascular failure in Austria. Lesions were indicative of elephant endotheliotropic herpesvirus (EEHV) associated disease, and the presence of EEHV6 could be detected by PCR. About two months later, an eight-year-old female elephant from the same herd showed typical clinical signs of EEHV-related hemorrhagic disease, which coincided with EEHV6 viremia. The animal underwent anti-herpesviral therapy and recovered quickly. Subsequently, blood and trunk wash samples from all elephants of the herd were monitored weekly for the presence of EEHV6-specific nucleic acids by qPCR. A retrospective analysis of the samples revealed repeated EEHV6 reactivation and the presence of EEHV3 in the samples of one animal. Our findings underline the threat EEHV6 poses to juvenile African elephants and emphasize the need for regular monitoring of viremia and virus excretion to prevent fatalities and predict transmission events.<\/jats:p>","DOI":"10.3390\/ani15101482","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T09:33:47Z","timestamp":1747733627000},"page":"1482","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Severe Elephant Endotheliotropic Herpesvirus 6 Associated Disease in Two African Elephants Under Human Care in Austria"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0421-5166","authenticated-orcid":false,"given":"Stella","family":"Kn\u00fcppel","sequence":"first","affiliation":[{"name":"Department of Biological Sciences and Pathobiology, Infectiology and Virology, University of Veterinary Medicine, Veterin\u00e4rplatz 1, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folko","family":"Balfanz","sequence":"additional","affiliation":[{"name":"Tiergarten Sch\u00f6nbrunn, Maxingstra\u00dfe 13 b, 1130 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-996X","authenticated-orcid":false,"given":"Christiane","family":"Riedel","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Pathobiology, Infectiology and Virology, University of Veterinary Medicine, Veterin\u00e4rplatz 1, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Strauss","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, University of Veterinary Medicine, Savoyenstra\u00dfe 1, 1160 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabitha E.","family":"Hoornweg","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Health Sciences, Division of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Dimmel","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Pathobiology, Infectiology and Virology, University of Veterinary Medicine, Veterin\u00e4rplatz 1, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Walk","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Pathobiology, Infectiology and Virology, University of Veterinary Medicine, Veterin\u00e4rplatz 1, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6096-3835","authenticated-orcid":false,"given":"Anna","family":"K\u00fcbber-Heiss","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, University of Veterinary Medicine, Savoyenstra\u00dfe 1, 1160 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Posautz","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, University of Veterinary Medicine, Savoyenstra\u00dfe 1, 1160 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Voracek","sequence":"additional","affiliation":[{"name":"Tier\u00e4rztliche Ordination Tiergarten Sch\u00f6nbrunn, Seckendorff-Gudent-Weg 6, 1130 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza","family":"Abdelgawad","sequence":"additional","affiliation":[{"name":"Center for Infection Medicine, Institute of Virology, School of Veterinary Medicine, Freie Univerit\u00e4t Berlin, Kaiserswerther Str. 16-18, 14195 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Trimpert","sequence":"additional","affiliation":[{"name":"Center for Infection Medicine, Institute of Virology, School of Veterinary Medicine, Freie Univerit\u00e4t Berlin, Kaiserswerther Str. 16-18, 14195 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Hering-Hagenbeck","sequence":"additional","affiliation":[{"name":"Tiergarten Sch\u00f6nbrunn, Maxingstra\u00dfe 13 b, 1130 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"R\u00fcmenapf","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Pathobiology, Infectiology and Virology, University of Veterinary Medicine, Veterin\u00e4rplatz 1, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4790-9823","authenticated-orcid":false,"given":"Angelika","family":"Auer","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Pathobiology, Infectiology and Virology, University of Veterinary Medicine, Veterin\u00e4rplatz 1, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1126\/science.283.5405.1171","article-title":"Novel Endotheliotropic Herpesviruses Fatal for Asian and African 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