{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:57:33Z","timestamp":1793905053628,"version":"4.8.0"},"reference-count":27,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"institutional activities in the field of veterinary public health of Istituto Zooprofilattico Sperimentale of Sardinia, Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Oxalis pes-caprae is one of the most widespread invasive plants in the Mediterranean areas, especially in central and southern Italy, Sicily, and Sardinia. It is an herbaceous species of South African origin, very common in uncultivated areas, in meadows, and at the edges of roads but also in vegetable gardens and fields, where it can become a weed. Its negative impact on the economic sector is significant due to the presence of large quantities of oxalates, which are toxic and dangerous for grazing livestock; the ingestion of high amounts of oxalates causes the accumulation of oxalate crystals, which can lead to kidney failure and anuria. This work represents a descriptive, field-based case report of epidemiological relevance, describing two cases of acute and chronic poisoning by Oxalis pes-caprae found in two different sheep farms in southern Sardinia. In February 2024, the sudden death of about 40 animals was reported in a sheep farm. On another farm, seven animals died (between March and July 2024), while others showed poisoning symptoms such as weight loss, submandibular edema, and a barrel-shaped abdomen. This manuscript aims to highlight the damage caused by poor attention in pasture management and the importance of seasonal risk management; it is necessary to pay attention to the herbaceous species present in pastures, especially in our region, where climatic temperatures no longer respect seasonality and herbaceous species that normally grow in spring are easily found also in the winter months.<\/jats:p>","DOI":"10.3390\/ani15111668","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T08:34:32Z","timestamp":1749112472000},"page":"1668","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Description of Acute and Chronic Cases of Poisoning by Oxalis pes-caprae"],"prefix":"10.3390","volume":"15","author":[{"given":"Luigia","family":"Pinna","sequence":"first","affiliation":[{"name":"S.C. Complex Territorial Diagnostic Structure of Cagliari, Istituto Zooprofilattico Sperimentale of Sardinia, Via dell\u2019Acquedotto Romano, 09030 Elmas-Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4724-3101","authenticated-orcid":false,"given":"Daniela","family":"Mandas","sequence":"additional","affiliation":[{"name":"S.C. Complex Territorial Diagnostic Structure of Cagliari, Istituto Zooprofilattico Sperimentale of Sardinia, Via dell\u2019Acquedotto Romano, 09030 Elmas-Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1645-4894","authenticated-orcid":false,"given":"Davide","family":"Pintus","sequence":"additional","affiliation":[{"name":"S.S. Anatomo-Histopathology and Animal Genetics, Sassari Section, Istituto Zooprofilattico Sperimentale of Sardinia, Via Vienna 2, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Zulato","sequence":"additional","affiliation":[{"name":"S.C. Complex Territorial Diagnostic Structure of Cagliari, Istituto Zooprofilattico Sperimentale of Sardinia, Via dell\u2019Acquedotto Romano, 09030 Elmas-Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Frongia","sequence":"additional","affiliation":[{"name":"S.C. Complex Territorial Diagnostic Structure of Cagliari, Istituto Zooprofilattico Sperimentale of Sardinia, Via dell\u2019Acquedotto Romano, 09030 Elmas-Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Maurichi","sequence":"additional","affiliation":[{"name":"S.C. Complex Territorial Diagnostic Structure of Cagliari, Istituto Zooprofilattico Sperimentale of Sardinia, Via dell\u2019Acquedotto Romano, 09030 Elmas-Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Coccollone","sequence":"additional","affiliation":[{"name":"S.C. Complex Territorial Diagnostic Structure of Cagliari, Istituto Zooprofilattico Sperimentale of Sardinia, Via dell\u2019Acquedotto Romano, 09030 Elmas-Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/aob\/mcl273","article-title":"Distribution of flower morphs, ploidy level and sexual reproduction of the invasive weed Oxalis pes-caprae in the western area of the Mediterranean region","volume":"99","author":"Castro","year":"2007","journal-title":"Ann. Bot."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Papini, A., Signorini, M.A., Foggi, B., Della Giovampaola, E., Ongaro, L., Vivona, L., Santosuosso, U., Tani, C., and Bruschi, P. (2017). History vs. legend: Retracing invasion and spread of Oxalis pes-caprae L. in Europe and the Mediterranean area. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0190237"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/aob\/mcl052","article-title":"Demography of the invasive geophyte Oxalis pes-caprae across a Mediterranean island","volume":"97","author":"Bartomeus","year":"2006","journal-title":"Ann. Bot."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Malfa, G.A., Bianchi, S., Spadaro, V., Di Giacomo, C., Raimondo, F.M., and Acquaviva, R. (2025). Oxalis pes-caprae L. (Oxalidaceae): From Invasive Concern to Promising Bioresource for Health and Sustainable Applications. Plants, 14.","DOI":"10.3390\/plants14040578"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF02860532","article-title":"Calcium Oxalate Crystals in Plants","volume":"46","author":"Franceschi","year":"1980","journal-title":"Bot. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-3-642-69083-9_50","article-title":"The contribution of veterinary toxicology to environmental health","volume":"6","author":"Egyed","year":"1983","journal-title":"Arch. Toxicol. Suppl."},{"key":"ref_7","unstructured":"Carlo, B. (1984). Tossicologia Veterinaria, Editoriale Grasso."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/S0041-0101(02)00239-8","article-title":"Poisonous plants affecting livestock in Brazil","volume":"40","author":"Tokarnia","year":"2002","journal-title":"Toxicon"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jep.2008.07.022","article-title":"Poisonous plants of veterinary and human importance in southern Africa","volume":"119","author":"Botha","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ruiz, H., Lacasta, D., Ramos, J.J., Quintas, H., Ruiz de Arcaute, M., Ramo, M.\u00c1., Villanueva-Saz, S., and Ferrer, L.M. (2022). Anaemia in Ruminants Caused by Plant Consumption. Animals, 12.","DOI":"10.3390\/ani12182373"},{"key":"ref_11","unstructured":"Gupta, R.C. (2007). Oxalate-containing plants. Veterinary Toxicology, Basic and Clinical Principle, Elsevier."},{"key":"ref_12","unstructured":"Keeler, R.F., Van Kampen, K.R., and James, L.F. (1978). Oxalate poisoning in livestock. Effects of Poisonous Plants on Livestock, Academic Press."},{"key":"ref_13","unstructured":"Haschek, W.M., Rousseaux, C.G., Wallig, M.A., Bolon, B., Heinz-taheny, K.M., Rudmann, D.G., and Mahler, B.W. (2023). Chapter 7\u2014Poisonous Plants. Haschek and Rousseaux\u2019s Handbook of Toxicologic Pathology, Academic Press. [4th ed.]."},{"key":"ref_14","first-page":"1173","article-title":"Changes in ruminal oxalate degradation rates associated with adaptation to oxalate ingestion","volume":"45","author":"Allison","year":"1977","journal-title":"J. Range Manag."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.2460\/javma.1990.196.12.1981","article-title":"Acute oxalate poisoning attributable to ingestion of curly dock (Rumex crispus) in sheep","volume":"196","author":"Panciera","year":"1990","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.cvfa.2020.08.006","article-title":"Plants Containing Urinary Tract, Gastrointestinal, or Miscellaneous Toxins that Affect Livestock","volume":"36","author":"Stegelmeier","year":"2020","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"ref_17","unstructured":"Stelletta, C., Di Marco Lo Presti, V., Mignacca, S.A., Aronica, V., Biasibetti, E., Capucchio, M.T., Zangh\u00ec, P., and Vazzana, I. (2012, January 26\u201329). Intossicazione acuta da piante contenenti acido ossalico (Oxalis pes-caprae) in un gregge ovino: Valutazioni cliniche ed anatomo-istopatologiche. Proceedings of the XX SIPAOC Congress, Siracusa, Italy."},{"key":"ref_18","unstructured":"Puleio, R., Loria, G.R., Tamburello, A., Zangh\u00ec, P., Vazzana, I., Mignacca, S., and Di Marco Lo Presti, V. (2012, January 26\u201329). Descrizione di un caso di intossicazione cronica da ossalati di calcio in ovini, rilievi anatomopatologici e istologici. Proceedings of the XX SIPAOC Congress, Siracusa, Italy."},{"key":"ref_19","unstructured":"Coccollone, A., Maurichi, M., Frongia, M., Cancedda, M.G., Macciocu, S., Mandas, D., and Pinna, L. (2024, January 17\u201320). Case report: Descrizione di due casi di intossicazione acuta e cronica da Oxalis pes-caprae in allevamenti ovini. Proceedings of the XXV SIPAOC Congress, Sassari, Italy."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s11250-011-9818-0","article-title":"Acute oxalate intoxication associated to ingestion of eshnan (Seidlitzia rosmarinus) in sheep","volume":"43","author":"Aslani","year":"2011","journal-title":"Trop. Anim. Health Prod."},{"key":"ref_21","first-page":"152","article-title":"Oxalate accumulation in fodder crops and impact on grazing animals\u2014A review","volume":"44","author":"Goyal","year":"2018","journal-title":"Forage Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1751-0813.1988.tb14926.x","article-title":"Acute oxalate poisoning of sheep by buffel grass (Cenchrus ciliaris)","volume":"65","author":"McKenzie","year":"1988","journal-title":"Aust. Vet. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0749-0720(15)30976-2","article-title":"Plants causing sudden death in livestock","volume":"5","author":"Burrows","year":"1989","journal-title":"Vet. Clin. N. Am. Food Anim. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1439-0396.2012.01309.x","article-title":"A review of oxalate poisoning in domestic animals: Tolerance and performance aspects","volume":"97","author":"Rahman","year":"2013","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_25","first-page":"37","article-title":"Dogs\u2019 Brain Electric Activity in Ethylene Glycol Poisoning","volume":"72","author":"Saftencu","year":"2015","journal-title":"Bull. UASVM Cluj Napoca Vet. Med."},{"key":"ref_26","first-page":"296","article-title":"Clinical and morphopathological aspects in anti-freeze intoxication of dogs","volume":"58","author":"Solcan","year":"2012","journal-title":"Sci. Works C Ser. Vet. Med."},{"key":"ref_27","unstructured":"Radostits, O.M., Gay, C.C., Hinchcliff, K.W., and Constable, P.D. (2007). Veterinary Medicine, Saunders-Elsevier. [10th ed.]."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/15\/11\/1668\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:47:03Z","timestamp":1760032023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/15\/11\/1668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":27,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["ani15111668"],"URL":"https:\/\/doi.org\/10.3390\/ani15111668","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]}}}