{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:22:55Z","timestamp":1784560975348,"version":"3.55.0"},"reference-count":29,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant-in-Aid for Scientific Research","award":["26660234"],"award-info":[{"award-number":["26660234"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["17K15384"],"award-info":[{"award-number":["17K15384"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study aimed to determine the factors associated with the occurrence of the first-wave dominant follicle (DF) in the ovary ipsilateral to the corpus luteum (CL) in lactating dairy cows and dairy heifers. A total of 505 estruses were investigated (lactating dairy cows, n = 361; dairy heifers, n = 144). The locations of the preovulatory follicle (PF) and regressed CL were examined at the estrus, and the locations of the first-wave dominant follicle (DF) and newly formed CL were examined seven days after estrus using transrectal ultrasonography. Then, cows were classified into two groups: the first-wave DF in the ovary ipsilateral to the CL (IG) and the first-wave DF in the ovary contralateral to the CL (CG). To evaluate the factors which affect the occurrence of IG and CG, binominal logistic regression analysis was conducted; the location of the PF and regressing CL, season (warm: June\u2013September; cool: October\u2013May), live weight, days in milk at estrus, daily milk production, and body condition score were used as independent variables. The occurrence rate of IG was significantly higher when the PF was located contralateral to the regressing CL (lactating dairy cows, 63.4%; dairy heifers, 58.6%) rather than ipsilateral (lactating dairy cows, 44.9%; dairy heifers, 35.1%). The IG occurrence rate was significantly higher with an increase in daily milk production (&lt;30 kg, 47.3%; 30\u201340 kg, 55.2%; &gt;40 kg, 60.5%) in lactating dairy cows. In conclusion, the occurrence of IG was associated with relative locations of the PF and regressing CL in lactating dairy cows and dairy heifers and with the level of milk production in lactating dairy cows.<\/jats:p>","DOI":"10.3390\/ani15152253","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T08:51:41Z","timestamp":1754038301000},"page":"2253","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors Associated with the Occurrence of the First-Follicular-Wave Dominant Follicle on the Ovary Ipsilateral to the Corpus Luteum in Dairy Cattle"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-0649","authenticated-orcid":false,"given":"Ryotaro","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Large Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069-0836, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motozumi","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro 080-8555, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1530\/jrf.0.0870223","article-title":"Temporal associations among ovarian events in cattle during oestrous cycles with two and three follicular waves","volume":"87","author":"Ginther","year":"1989","journal-title":"J. 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