{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:37:45Z","timestamp":1760060265979,"version":"build-2065373602"},"reference-count":69,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Amirthalingamia macracantha (Joyeux and Baer, 1935) larvae, a member of the Gryporhynchidae family (Cestoda: Cyclophyllidea), are commonly found in a variety of African fish species, including Nile tilapia (Oreochromis niloticus, Linnaeus, 1758). Nonetheless, little is known regarding their existence in native Egyptian fish species. Two hundred O. niloticus were examined in the current investigation, using standard parasitological techniques to detect the presence of these larvae in different fish organs. According to this study\u2019s findings, A. macracantha larvae were found in 35% of the microscopically examined samples as red nodules, attaching to the serosa of both the anterior and posterior sections of the intestine and stomach, respectively. The mean abundance of the infection was 3.5 \u00b1 0.05 (CI 95% 3.4\u20133.5), and its mean intensity was 10 \u00b1 1.7 (CI 95% 8.2\u201311.7). The existence of two rows of twenty rostellar hooks of varying lengths is the main characteristic of the parasite. The upper row consisted of four large hooks and six smaller ones, while the lower row contained smaller hooks of consistent length. According to histopathological analysis, the larvae with a hook-and-spiny rostellum were affixed to the stomach serosa of O. niloticus. Additionally, there was a notable presence of degranulated mast cells and lymphocytes of varying sizes within the stomach\u2019s lamina propria, submucosa, and blood vessels, as well as a loss of gastric epithelium, fibrosis, and enlargement of submucosal lymph vessels. This study offers a succinct description of this larval stage, representing the first reported occurrence of its presence in Egyptian O. niloticus.<\/jats:p>","DOI":"10.3390\/ani15162334","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T08:10:32Z","timestamp":1754899832000},"page":"2334","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Amirthalingamia macracantha Larvae on Nile Tilapia (Oreochromis niloticus): A Morpho-Histopathological Perspective"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8585-8123","authenticated-orcid":false,"given":"Ebtsam Sayed Hassan","family":"Abdallah","sequence":"first","affiliation":[{"name":"Department of Aquatic Animal Medicine and Management, Faculty of Veterinary Medicine, Assiut University, Assiut 71529, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2269-531X","authenticated-orcid":false,"given":"Mahmoud Mostafa","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Aquatic Animal Medicine and Management, Faculty of Veterinary Medicine, Assiut University, Assiut 71529, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2547-0709","authenticated-orcid":false,"given":"Hanan Hassan","family":"Abdel-Hafeez","sequence":"additional","affiliation":[{"name":"Department of Cell and Tissue, Faculty of Veterinary Medicine, Assiut University, Assiut 71516, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-2755","authenticated-orcid":false,"given":"Marco","family":"Albano","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Polo Universitario Dell\u2019Annunziata, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2002-1138","authenticated-orcid":false,"given":"Gioele","family":"Capillo","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D\u2019Alcontres 31, 98166 Messina, Italy"},{"name":"Sea in Health and Life Srl, Capo Peloro, 98164 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa Mohamed","family":"Metwally","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sultan Mohammed","family":"Areshi","sequence":"additional","affiliation":[{"name":"Biology Department, Science College, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalal","family":"Alardan","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, University of Hail, Hail 2440, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3097-2233","authenticated-orcid":false,"given":"Yosra M. I.","family":"El Sherry","sequence":"additional","affiliation":[{"name":"Department of Fish Diseases, Faculty of Veterinary Medicine, Aswan University, Sahari, Airport Way, Aswan 81528, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"key":"ref_1","unstructured":"FAO (2020). The State of World Fisheries and Aquaculture (2020). Sustainability in Action, FAO."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/raq.12738","article-title":"From Africa to the world\u2014The journey of Nile tilapia","volume":"15","author":"Fitzsimmons","year":"2023","journal-title":"Rev. Aquac."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0044-8486(99)00217-3","article-title":"A review of strategies for the management of Nile tilapia (Oreochromis niloticus) broodfish in seed production systems, especially hapa-based systems","volume":"181","author":"Bhujel","year":"2000","journal-title":"Aquaculture"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1753-5131.2009.01017.x","article-title":"Use and exchange of genetic resources of Nile tilapia (Oreochromis niloticus)","volume":"1","author":"Eknath","year":"2009","journal-title":"Rev. Aquac."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1007\/s00436-018-6042-0","article-title":"Effect of water quality on the parasite assemblages infecting Nile tilapia in selected fish farms in Nakuru County, Kenya","volume":"117","author":"Ojwala","year":"2018","journal-title":"Parasitol. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1016\/j.ygeno.2021.06.037","article-title":"Epigenetic mapping of the somatotropic axis in Nile tilapia reveals differential DNA hydroxymethylation marks associated with growth","volume":"113","author":"Konstantinidis","year":"2021","journal-title":"Genomics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1095-8649.1999.tb00638.x","article-title":"A study of the histology of the digestive tract of the Nile tilapia","volume":"54","author":"Morrison","year":"1999","journal-title":"J. Fish Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/raq.12742","article-title":"A global review of problematic and pathogenic parasites of farmed tilapia","volume":"15","author":"Shinn","year":"2023","journal-title":"Rev. Aquac."},{"key":"ref_9","unstructured":"Caira, J.N., JensEn, K., Georgiev, B.B., Kuchta, R., Littlewood, T., Mariaux, J., Scholz, T., Tkach, V.V., and Waeschenbach, A. (2018). An overview of the tapeworms of vertebrate bowels of the earth. Planetary Biodiversity Inventory (2008\u20132017): Tapeworms from the Vertebrate Bowels of the Earth, University of Kansas, Natural History Museum."},{"key":"ref_10","unstructured":"Uhrov\u00e1, L. (2016). Diverzita Larv\u00e1ln\u00edch St\u00e1di\u00ed Tasemnic \u010celedi Gryporhynchidae (Cestoda: Cyclophyllidea) z Cichlidn\u00edchryb (Perciformes: Cichlidae) Ji\u017en\u00ed Afriky, University of South Bohemia in \u010cesk\u00e9 Bud\u011bjovice the Faculty of Natural Science."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.14411\/fp.2004.018","article-title":"Larvae of gryporhynchid cestodes (Cyclophyllidea) from fish: A review","volume":"51","author":"Scholz","year":"2004","journal-title":"Folia Parasitol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1654\/4331.1","article-title":"New metacestodes of gryporhynchid tapeworms (Cestoda: Cyclophyllidea) from carp (Cyprinus carpio Linnaeus, 1758) from Mozambique, Africa","volume":"75","author":"Scholz","year":"2008","journal-title":"Comp. Parasitol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00436-011-2649-0","article-title":"Infection patterns of Nile tilapia (Oreochromis niloticus L.) by two helminth species with contrasting life styles","volume":"110","author":"Akoll","year":"2012","journal-title":"Parasitol. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1079\/JOH2001105","article-title":"A comparative study of helminth parasites from the fish Tilapia zillii and Oreochromis leucostictus in Lake Naivasha and Oloidien Bay, Kenya","volume":"76","author":"Aloo","year":"2002","journal-title":"J. Helminthol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1080\/00222937400770501","article-title":"A new genus of dilepidid cestode in Tilapia nilotica (L., 1757) and Phalacrocorax carbo (L., 1758) in Sudan","volume":"8","author":"Bray","year":"1974","journal-title":"J. Nat. Hist."},{"key":"ref_16","first-page":"51","article-title":"Veterinary and public health aspects in tilapia (Oreochromis niloticus niloticus) aquaculture in Kenya, Uganda and Ethiopia","volume":"6","author":"Florio","year":"2009","journal-title":"Ittiopatologia"},{"key":"ref_17","first-page":"73","article-title":"Study on parasitic helminths infecting three fish species from Koka reservoir, Ethiopia","volume":"36","author":"Gulelat","year":"2013","journal-title":"SINET Ethiop. J. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1515\/helm-2017-0054","article-title":"Optimum Sample Size to Estimate Mean Parasite Abundance in Fish Parasite Surveys","volume":"55","author":"Shvydka","year":"2018","journal-title":"Helminthologia"},{"key":"ref_19","unstructured":"Eissa, A.E. (2016). Clinical and Laboratory Manual of Fish Diseases, LAP LAMBERT Academic Publishing."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Noga, E.J. (2010). Fish Disease: Diagnosis and Treatment, Iowa State University Press. [2nd ed.].","DOI":"10.1002\/9781118786758"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0044-8486(03)00483-6","article-title":"Accumulation and clearance of the anaesthetics clove oil and AQUI-S\u2122 from the edible tissue of silver perch (Bidyanus bidyanus)","volume":"232","author":"Kildea","year":"2004","journal-title":"Aquaculture"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Abdallah, E.S.H., and Hamouda, A.H. (2022). Livoneca redmanii Leach, 1818 (Cymothoidae) a parasitic isopod infesting the gills of the European seabass, Dicentrarchus labrax (Linnaeus, 1758): Morphological and molecular characterization study. BMC Vet. Res., 18.","DOI":"10.1186\/s12917-022-03405-2"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejar.2022.07.006","article-title":"Morphological and molecular characterization of Lernanthropus kroyeri, a copepod infesting the gills of European seabass Dicentrarchus labrax","volume":"49","author":"Abdallah","year":"2023","journal-title":"Egypt. J. Aquat. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.21608\/avmj.2018.168947","article-title":"Parasitic infections of the gills of wild African Sharptooth Catfish (Clarias gariepinus)","volume":"64","author":"Mahmoud","year":"2018","journal-title":"Assiut Vet. Med. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.1111\/are.15980","article-title":"Morphological and molecular identification of third-stage Contracaecum larvae (Nematoda: Anisakidae) parasitizing Nile perch Lates niloticus in Egypt","volume":"53","author":"Thabit","year":"2022","journal-title":"Aquac. Res."},{"key":"ref_26","first-page":"1","article-title":"Lamproglena monodi (Copepoda: Lernaeidae), infesting gills of Oreochromis niloticus and Tilapia zillii","volume":"6","author":"Hassan","year":"2013","journal-title":"Glob. J. Fish. Aquac. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.21608\/avmj.2017.170945","article-title":"Acanthogyrus tilapiae Infections in Wild and Cultured Nile tilapia Oreochromis niloticus","volume":"63","author":"Abdallah","year":"2017","journal-title":"Assiut Vet. Med. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2307\/3284227","article-title":"Parasitology meets ecology on its own terms: Margolis et al. revisited","volume":"83","author":"Bush","year":"1997","journal-title":"J. Parasitol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pt.2019.01.003","article-title":"Biostatistics for parasitologists\u2014A primer to quantitative parasitology","volume":"35","author":"Reiczigel","year":"2019","journal-title":"Trends Parasitol."},{"key":"ref_30","unstructured":"Pauly, D. (1983). Some Simple Methods for the Assessment of Tropical Fish Stocks, FAO. FAO fisheries technical paper No 234."},{"key":"ref_31","first-page":"1","article-title":"Morphological and morphometric study of the development of seminiferous epithelium of donkey (Equus asinus) from birth to maturity","volume":"6","author":"Moustafa","year":"2015","journal-title":"J. Cytol. Histol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Hassan, M.S., Abd-Allah, E.A., El-Amir, Y.O., Fayed, H., and Abdelhafeez, H.H. (2025). Histopathological Investigation and Plasma Energy Metabolic Profile as A diagnostic Tools of Postpartum Metritis and its Implication on Reproductive Performance of Dairy Cows. Egypt. J. Vet. Sci., 1\u201316.","DOI":"10.21608\/ejvs.2025.352315.2599"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/jemt.23602","article-title":"Pathological and immunohistochemical studies following the experimental infection of ayu (Plecoglossus altivelis) by Edwardsiella ictaluri","volume":"84","author":"Gaafar","year":"2021","journal-title":"Microsc. Res. Tech."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"D\u2019Iglio, C., Albano, M., Famulari, S., Span\u00f2, N., Rinelli, P., Savoca, S., and Capillo, G. (2022). Basic Intersexuality (Abnormal Hermaphroditism) in the Blackmouth Catshark, Galeus melastomus,(Rafinesque, 1810), from the Southern Tyrrhenian Sea (Central Mediterranean Sea). Fishes, 7.","DOI":"10.3390\/fishes7030120"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Fournie, J.W., Krol, R.M., and Hawkins, W.E. (2000). Fixation of fish tissues. The Laboratory Fish, Elsevier.","DOI":"10.1016\/B978-012529650-2\/50043-3"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3354\/dao02984","article-title":"Angioleiomyoma in a conger (Conger conger)","volume":"119","author":"Marino","year":"2016","journal-title":"Dis. Aquat. Org."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Abdel-Hakeem, S.S., Fadladdin, Y.A.J., Khormi, M.A., and Abd-El-Hafeez, H.H. (2024). Modulation of the intestinal mucosal and cell-mediated response against natural helminth infection in the African catfish Clarias gariepinus. BMC Vet. Res., 20.","DOI":"10.1186\/s12917-024-04153-1"},{"key":"ref_38","first-page":"217","article-title":"Mission Saharienne Augieras-Draper, 1927\u20131928","volume":"2","author":"Joyeux","year":"1930","journal-title":"Cestodes. Bull. Mus. Nat. Hist. Nat."},{"key":"ref_39","unstructured":"J\u00e4gerski\u00f6ld, L.A. (1909). Die Cestoden der V\u00f6gel des weissen Nils. Results of the Swedish Zoological Expedition to Egypt and the White Nile, 1901, BioStor. Part 3."},{"key":"ref_40","first-page":"482","article-title":"Notices helminthologiques","volume":"60","author":"Joyeux","year":"1935","journal-title":"Bull. Soc. zool. Fr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2478\/s11686-020-00178-2","article-title":"Parasite communities of Oreochromis niloticus baringoensis (Trewavas, 1983) in relation to selected water quality parameters in the springs of Lorwai Swamp and Lake Baringo, Kenya","volume":"65","author":"Adamba","year":"2020","journal-title":"Acta Parasitol."},{"key":"ref_42","unstructured":"Otachi, E.O. (2013). Parasites of Fish and Trace Elements in Lakes Naivasha and Turkana, Kenya. [PhD Thesis, Universit\u00e4t Wien]."},{"key":"ref_43","unstructured":"Scholz, T., Vanhove, M., Smit, N., Jayasundera, Z., and Gelnar, M. (2018). A Guide to the Parasites of African Freshwater Fishes, Royal Belgian Institute of Natural Sciences Brussels."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1017\/S0022149X18000846","article-title":"Phylogenetic relationships of the family Gryporhynchidae (Cestoda: Cyclophyllidea) inferred through SSU and LSU rDNA sequences","volume":"93","year":"2019","journal-title":"J. Helminthol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s11230-018-9796-y","article-title":"An annotated list and molecular data on larvae of gryporhynchid tapeworms (Cestoda: Cyclophyllidea) from freshwater fishes in Africa","volume":"95","author":"Scholz","year":"2018","journal-title":"Syst. Parasitol."},{"key":"ref_46","first-page":"123","article-title":"Parasites fauna of farmed African catfish (Clarias gariepinus) in Osogbo, Osun State, Southwestern Nigeria","volume":"20","author":"Rufai","year":"2017","journal-title":"Ann. West Univ. Timisoara. Ser. Biol."},{"key":"ref_47","first-page":"118","article-title":"Food and feeding habits of Oreochromis niloticus (L.) and Sarotherodon galilaeus (L.) in a tropical reservoir","volume":"1","author":"Oso","year":"2006","journal-title":"World J. Zool."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1095-8649.1993.tb00573.x","article-title":"Herbivory in the tilapia Oreochromis niloticus: A comparison of feeding rates on phytoplankton and periphyton","volume":"43","author":"Dempster","year":"1993","journal-title":"J. Fish Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00008157","article-title":"The food habits of an herbivorous fish (Oreochromis niloticus Linn.) in Lake Awasa, Ethiopia","volume":"174","author":"Getachew","year":"1989","journal-title":"Hydrobiologia"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00436-011-2491-4","article-title":"Parasite fauna of farmed Nile tilapia (Oreochromis niloticus) and African catfish (Clarias gariepinus) in Uganda","volume":"110","author":"Akoll","year":"2012","journal-title":"Parasitol. Res."},{"key":"ref_51","unstructured":"Tadesse, B. (2009). Prevalence and adundance of fish parasites in Bomosa Cage Systems and lakes Babogaya and Awassa, Ethiopia. [Master\u2019s Thesis, Delft Unesco-IHEna]."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Khan, R. (2012). Host-parasite interactions in some fish species. J. Parasitol. Res.","DOI":"10.1155\/2012\/237280"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1139\/z73-021","article-title":"The role of plerocercoids in the biology of Proteocephalus ambloplitis (Cestoda) maturing in smallmouth bass","volume":"51","author":"Fischer","year":"1973","journal-title":"Can. J. Zool."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00040163","article-title":"Limnological studies of and primary production in temple pond ecosystems","volume":"48","author":"Sreenivasan","year":"1976","journal-title":"Hydrobiologia"},{"key":"ref_55","first-page":"1980","article-title":"Water quality guidelines for the management of pond fish culture","volume":"3","author":"Bhatnagar","year":"2013","journal-title":"Int. J. Environ. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pt.2004.01.014","article-title":"Environmental parasitology: Relevancy of parasites in monitoring environmental pollution","volume":"20","author":"Sures","year":"2004","journal-title":"Trends Parasitol."},{"key":"ref_57","first-page":"4460","article-title":"Condition factors of seven Cyprinid fish species from \u00c7amlig\u00f6ze dam lake on central Anatolia, Turkey","volume":"7","author":"Dirican","year":"2012","journal-title":"Afr. J. Agric. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"186","DOI":"10.21077\/ijf.2017.64.special-issue.76263-27","article-title":"Length-weight relationship and condition factor of indian major carps of Vallabhsagar Reservoir, Gujarat, India","volume":"64","author":"Soni","year":"2017","journal-title":"Indian J. Fish."},{"key":"ref_59","first-page":"82","article-title":"Length-weight relationship and condition factor of pond reared juvenile Oreochromis niloticus","volume":"1","author":"Olurin","year":"2006","journal-title":"World J. Zool."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1111\/evo.14574","article-title":"Adaptive division of growth and development between hosts in helminths with two-host life cycles","volume":"76","author":"Benesh","year":"2022","journal-title":"Evolution"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1128\/CMR.05040-11","article-title":"Helminth infections and host immune regulation","volume":"25","author":"McSorley","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Lu, F., and Huang, S. (2017). The roles of mast cells in parasitic protozoan infections. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00363"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez, M., Cervantes-Garc\u00eda, D., C\u00f3rdova-D\u00e1valos, L.E., P\u00e9rez-Rodr\u00edguez, M.J., Gonzalez-Espinosa, C., and Salinas, E. (2021). Responses of mast cells to pathogens: Beneficial and detrimental roles. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.685865"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/fsim.1997.0108","article-title":"Mast cells\/eosinophilic granule cells of salmonids: Staining properties and responses to noxious agents","volume":"7","author":"Reite","year":"1997","journal-title":"Fish Shellfish Immunol."},{"key":"ref_65","first-page":"245","article-title":"Uterine smooth muscle cells express functional receptors (flt-1 and KDR) for vascular permeability factor\/vascular endothelial growth factor","volume":"76","author":"Brown","year":"2019","journal-title":"Lab. Investig."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nri2782","article-title":"Mast cell-orchestrated immunity to pathogens","volume":"10","author":"Abraham","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.coi.2006.11.006","article-title":"New and emerging roles for mast cells in host defence","volume":"19","author":"Dawicki","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1172\/JCI200113930","article-title":"Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization","volume":"108","author":"Mazzoni","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e2954","DOI":"10.21897\/rmvz.2954","article-title":"Parvitaenia cochlearii (Cestoda: Gryporhynchidae) en cultivo de chame Dormitator latifrons en Ecuador","volume":"28","year":"2023","journal-title":"Rev. MVZ C\u00f3rdoba"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/15\/16\/2334\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:27:04Z","timestamp":1760034424000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/15\/16\/2334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,9]]},"references-count":69,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["ani15162334"],"URL":"https:\/\/doi.org\/10.3390\/ani15162334","relation":{},"ISSN":["2076-2615"],"issn-type":[{"type":"electronic","value":"2076-2615"}],"subject":[],"published":{"date-parts":[[2025,8,9]]}}}