{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:21:33Z","timestamp":1776273693878,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science, Research and Innovation Fund (NSRF) and Prince of Songkla University","award":["VET6801015S"],"award-info":[{"award-number":["VET6801015S"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Dugongs (Dugong dugon), classified as vulnerable marine mammals, are increasingly impacted by infectious diseases, yet the role of septicemia and disseminated intravascular coagulation (DIC) in their mortality remains uncharacterized. This study aimed to investigate the pathological and microbiological features associated with an acute mortality event in a juvenile dugong during rehabilitation in southern Thailand. Comprehensive histopathological and microbiological analyses were conducted on tissue samples collected postmortem. Bacterial isolation and identification were performed using standard culture techniques and the VITEK-2 system. Histological examination revealed multisystemic lesions, including fibrin thrombi, hemorrhage, hepatocellular degeneration, pancreatic necrosis, lymphoid depletion, and neuronal damage. Oxidative stress and DNA damage were confirmed in brain tissues through immunofluorescence detection of 4-hydroxynonenal (4-HNE) and 8-hydroxy-2\u2032-deoxyguanosine (8-oxodG). Achromobacter xylosoxidans, an opportunistic pathogen, was isolated from multiple organs, consistent with acute systemic infection. These findings represent the first evidence of septicemia-associated DIC in dugongs caused by A. xylosoxidans, highlighting a previously undocumented cause of mortality in dugongs. The results emphasize the role of opportunistic bacteria in triggering oxidative damage and coagulopathy and underscore the importance of early detection and targeted therapeutic strategies to improve survival in stranded or rehabilitated dugongs.<\/jats:p>","DOI":"10.3390\/ani15162441","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:18:14Z","timestamp":1755695894000},"page":"2441","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel Insight into Dugong Mortality: First Report of Systemic Achromobacter xylosoxidans Infection, Disseminated Intravascular Coagulation, and Associated Pathogenesis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-9889","authenticated-orcid":false,"given":"Piyaporn","family":"Eiamcharoen","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyarat","family":"Khumraksa","sequence":"additional","affiliation":[{"name":"Marine and Coastal Resources Research Center (Lower Andaman Sea), Trang 92150, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santi","family":"Ninwat","sequence":"additional","affiliation":[{"name":"Marine and Coastal Resources Research Center (Lower Andaman Sea), Trang 92150, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8410-3095","authenticated-orcid":false,"given":"Tatsawan","family":"Suttiboon","sequence":"additional","affiliation":[{"name":"Marine and Coastal Resources Research Center (Lower Gulf of Thailand), Songkhla 90100, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narissara","family":"Keawchana","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, Prince of Songkla University, Songkhla 90110, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-9446","authenticated-orcid":false,"given":"Peerapon","family":"Sornying","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, Prince of Songkla University, Songkhla 90110, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4815-1679","authenticated-orcid":false,"given":"Watcharapol","family":"Suyapoh","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, Prince of Songkla University, Songkhla 90110, Thailand"},{"name":"Dugong and Seagrass Research Station, Prince of Songkla University, Songkhla 90112, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"ref_1","unstructured":"IUCN Red List of Threatened Species (2025, June 25). Dugong\u00a0Dugon. Available online: https:\/\/www.iucnredlist.org\/species\/6909\/160756767."},{"key":"ref_2","first-page":"58","article-title":"Conserv\u00a0","volume":"58","author":"Hines","year":"2012","journal-title":"Dugongs Asia Pac."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1578\/AM.48.3.2022.203","article-title":"A systematic review of the status, knowledge, and research gaps of dugong in Southeast Asia","volume":"48","author":"Panyawai","year":"2022","journal-title":"Aquat. Mamm."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.japb.2019.12.002","article-title":"Measuring the nonuse value of the dugong (Dugong dugon) in Thailand","volume":"13","author":"Petcharat","year":"2020","journal-title":"J. Asia-Pac. Biodivers."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ng, S.Z.H., Ow, Y.X., and Jaafar, Z. (2022). Dugongs (Dugong dugon) along hyper-urbanized coastlines. Front. Mar. Sci., 9.","DOI":"10.3389\/fmars.2022.947700"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.14202\/vetworld.2024.2889-2898","article-title":"Investigation into the causes of mortality in cetaceans and sirenian populations in the Andaman Sea, Thailand: A retrospective analysis spanning 2018\u20132023","volume":"17","author":"Daochai","year":"2024","journal-title":"Vet. World"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3354\/dao02726","article-title":"Cetacean strandings in Italy: An unusual mortality event along the Tyrrhenian Sea coast in 2013","volume":"109","author":"Casalone","year":"2014","journal-title":"Dis. Aquat. Organ."},{"key":"ref_8","first-page":"1674","article-title":"Molecular, serological, pathological, immunohistochemical and microbiological investigation of Brucella spp. in marine mammals of Brazil reveals new cetacean hosts","volume":"66","author":"Carvalho","year":"2019","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"D\u00edaz-Delgado, J., Fern\u00e1ndez, A., Sierra, E., Sacchini, S., Andrada, M., Vela, A.I., Quesada-Canales, \u00d3., Paz, Y., Zucca, D., and Groch, K. (2018). Pathologic findings and causes of death of stranded cetaceans in the Canary Islands (2006\u20132012). PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0204444"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.1038\/s41467-023-41182-0","article-title":"Highly pathogenic avian influenza A (H5N1) in marine mammals and seabirds in Peru","volume":"14","author":"Leguia","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1890\/07-0862.1","article-title":"A Bayesian uncertainty analysis of cetacean demography and bycatch mortality using age-at-death data","volume":"18","author":"Moore","year":"2008","journal-title":"Ecol. Appl."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"IJsseldijk, L.L., Camphuysen, K.C., Keijl, G.O., Troost, G., and Aarts, G. (2021). Predicting harbor porpoise strandings based on near-shore sightings indicates elevated temporal mortality rates. Front. Mar. Sci., 8.","DOI":"10.3389\/fmars.2021.668038"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Obusan, M.C.M., Caras, J.A.A., Lumang, L.S.L., Calderon, E.J.S., Villanueva, R.M.D., Salibay, C.C., Siringan, M.A.T., Rivera, W.L., Masangkay, J.S., and Aragones, L.V. (2021). Bacteriological and histopathological findings in cetaceans that stranded in the Philippines from 2017 to 2018. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0243691"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"536","DOI":"10.7589\/0090-3558-42.3.536","article-title":"Aerobic microorganisms associated with free-ranging bottlenose dolphins in coastal Gulf of Mexico and Atlantic Ocean waters","volume":"42","author":"Buck","year":"2006","journal-title":"J. Wildl. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.vetmic.2010.08.025","article-title":"Isolation of culturable microorganisms from free-ranging bottlenose dolphins (Tursiops truncatus) from the southeastern United States","volume":"148","author":"Morris","year":"2011","journal-title":"Vet. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Obusan, M.C.M., Villanueva, R.M.D., Siringan, M.A.T., Rivera, W.L., and Aragones, L.V. (2019). Leptospira spp. and Toxoplasma gondii in stranded representatives of wild cetaceans in the Philippines. BMC Vet. Res., 15.","DOI":"10.1186\/s12917-019-2112-5"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1578\/AM.41.2.2015.149","article-title":"Occurrence of human pathogenic bacteria and Toxoplasma gondii in cetaceans stranded in the Philippines: Providing clues on ocean health status","volume":"41","author":"Obusan","year":"2015","journal-title":"Aquat. Mamm."},{"key":"ref_18","unstructured":"Sukkarun, P., Arnuphapprasert, A., Khumraksa, P., Daochai, C., Jantrakajorn, S., Keawchana, N., Sornying, P., and Suyapoh, W. (2025, January 16\u201317). Identification and Pathological Assessment of Mycobacterium spp. Infections in Wild Marine Mammals from the Andaman Sea, Thailand. Proceedings of the 26th Khon Kaen Veterinary Annual International Conference (KVAC), Khon Kaen, Thailand."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/j.2042-7670.2000.tb23974.x","article-title":"Pulmonary pathology of harbour porpoises (Phocoena phocoena) stranded in England and Wales between 1990 and 1996","volume":"146","author":"Jepson","year":"2000","journal-title":"Vet. Rec."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sierra, E., Fern\u00e1ndez, A., Felipe-Jim\u00e9nez, I., Zucca, D., D\u00edaz-Delgado, J., Puig-Lozano, R., C\u00e2mara, N., Consoli, F., D\u00edaz-Santana, P., and Su\u00e1rez-Santana, C. (2020). Histopathological differential diagnosis of meningoencephalitis in cetaceans. Front. Vet. Sci., 7.","DOI":"10.3389\/fvets.2020.00650"},{"key":"ref_21","first-page":"509","article-title":"Environmentally transmitted pathogens","volume":"Volume 10","author":"Pepper","year":"2015","journal-title":"Environmental Microbiology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e2010024","DOI":"10.4084\/mjhid.2010.024","article-title":"Sepsis-associated disseminated intravascular coagulation and thromboembolic disease","volume":"2","author":"Semeraro","year":"2010","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.vetmic.2015.01.019","article-title":"Septicaemia and meningitis in sea lion pups with hypermucoviscous Klebsiella pneumoniae","volume":"176","author":"Roe","year":"2015","journal-title":"Vet. Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/vcp.12540","article-title":"Coagulation and fibrinolysis in northern elephant seals","volume":"46","author":"Kaye","year":"2017","journal-title":"Vet. Clin. Pathol."},{"key":"ref_25","first-page":"181","article-title":"Age determination of the dugong (Dugong dugon) in northern Australia and its biological implications","volume":"3","author":"Marsh","year":"1980","journal-title":"Rep. Int. Whal. Comm. Spec. Iss."},{"key":"ref_26","unstructured":"Department of Marine and Coastal Resources (DMCR) (2013). Dugong Necropsy Manual in Thailand, Department of Marine and Coastal Resources. (In Thai)."},{"key":"ref_27","unstructured":"Abutarbush, S.M. (2007). Veterinary Medicine\u2014A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats, Saunders Elsevier. [10th ed.]."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Goudalier, C., Mouillot, D., Bernagou, L., Boksmati, T., Bristol, C., Clark, H., Herandarudewi, S.M.C., Hocd\u00e9, R., Koester, A., and McIvor, A.J. (Remote Sens. Ecol. Conserv., 2025). Drone photogrammetry reveals contrasting body conditions of dugongs across the Indo-Pacific, Remote Sens. Ecol. Conserv., in press.","DOI":"10.1002\/rse2.70016"},{"key":"ref_29","unstructured":"Pugliares, K.R., Bogomolni, A., Touhey, K.M., Herzig, S.M., and Harry, C.T. (2007). Marine Mammal Necropsy: An Introductory Guide, NOAA Fisheries."},{"key":"ref_30","unstructured":"Eros, C., Marsh, H., Bonde, R., O\u2019Shea, T., Beck, C., Recchia, C., Dobbs, K., Turner, M., Lemm, S., and Pears, R. (2007). Procedures for the Salvage and Necropsy of the Dugong, Great Barrier Reef Marine Park Authority. GBRMPA Research Publication No. 85."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Suyapoh, W., Nilake, C., Sriamad, A., Assawakulkamneard, T., Prasertsee, T., and Jantrakajorn, S. (2025). First report of Streptococcus iniae infection in cultured spotted scat (Scatophagus argus) in Thailand. J. Fish Dis., e70031.","DOI":"10.1111\/jfd.70031"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.diagmicrobio.2006.12.008","article-title":"Laboratory-based evaluation of the colorimetric VITEK-2 Compact system for species identification and of the advanced expert system for detection of antimicrobial resistances: VITEK-2 Compact system identification and antimicrobial susceptibility testing","volume":"58","author":"Nakasone","year":"2007","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/ajcp\/45.4_ts.493","article-title":"Antibiotic susceptibility testing by a standardized single disk method","volume":"45","author":"Bauer","year":"1966","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e13914","DOI":"10.1111\/jfd.13914","article-title":"Mixed Eimeria and Cryptosporidium infection and its effects on pathology and clinical outcomes in juvenile Asian seabass (Lates calcarifer) cultured in Thailand","volume":"47","author":"Suyapoh","year":"2024","journal-title":"J. Fish Dis."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Suyapoh, W., Thaweechart, B., Wae-asae, P., Keawchana, N., Sornying, P., Manmoo, S., Rakwong, P., and Jantrakajorn, S. (2025). Detection and pathological effects of intestinal parasites in spotted scat Scatophagus argus: Filisoma spp. and Cryptosporidium spp. as infective agents and their roles in fish inflammatory response. J. Aquat. Anim. Health, vsaf009.","DOI":"10.1093\/jahafs\/vsaf009"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e13114","DOI":"10.1111\/jwas.13114","article-title":"Intestinal inflammation, oxidative damage, and pathogenesis of intestinal Cryptosporidium in juvenile Asian sea bass (Lates calcarifer)","volume":"56","author":"Jantrakajorn","year":"2024","journal-title":"J. World Aquacult. Soc."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ooi, V., McMichael, L., Hunter, M.E., Takoukam Kamla, A., and Lanyon, J.M. (2023). A new DNA extraction method (HV-CTAB-PCI) for amplification of nuclear markers from open ocean-retrieved faeces of an herbivorous marine mammal, the dugong. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0278792"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/vcp.12249","article-title":"Serum biochemistry reference intervals of live wild dugongs (Dugong dugon) from urban coastal Australia","volume":"44","author":"Lanyon","year":"2015","journal-title":"Vet. Clin. Pathol."},{"key":"ref_39","unstructured":"Bennett, J.E., Dolin, R., and Blaser, M.J. (2015). Other gram-negative and gram-variable bacilli. Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases, W.B. Saunders. [8th ed.]."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bjid.2013.01.008","article-title":"Bacteremia due to Achromobacter xylosoxidans in neonates: Clinical features and outcome","volume":"17","author":"Turel","year":"2013","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_41","first-page":"268","article-title":"Achromobacter xylosoxidans bacteremia: Clinical and microbiological features in a 10-year case series","volume":"31","author":"Corbella","year":"2018","journal-title":"Rev. Esp. Quimioter."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4103\/amhs.amhs_222_22","article-title":"A case of bacteremia by Achromobacter xylosoxidans in an immunocompromised host and review of literature","volume":"11","author":"Rajni","year":"2023","journal-title":"Arch. Med. Health Sci."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Steiner, V., Rosel, A.C., Ruppitsch, W., Allerberger, F., Carranza Valencia, A., Markovic, M., Luckschander-Zeller, N., Szostak, M.P., Spergser, J., and Loncaric, I. (2021). The first bacterial endocarditis due to Achromobacter xylosoxidans in a dog. Pathogens, 10.","DOI":"10.3390\/pathogens10121580"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1748-5827.2006.00142.x","article-title":"Infection of a total hip prosthesis in a dog caused by Achromobacter (Alcaligenes) xylosoxidans","volume":"47","author":"Girling","year":"2006","journal-title":"J. Small Anim. Pract."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"930","DOI":"10.7589\/2017-01-012","article-title":"Fatal systemic salmonellosis in a Florida manatee (Trichechus manatus latirostris)","volume":"53","author":"Vorbach","year":"2017","journal-title":"J. Wildl. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Landsberg, J.H., Tabuchi, M., Rotstein, D.S., Subramaniam, K., Rodrigues, T.C.S., Waltzek, T.B., Stacy, N.I., Wilson, P.W., Kiryu, Y., and Uzal, F.A. (2022). Novel lethal clostridial infection in Florida manatees (Trichechus manatus latirostris): Cause of the 2013 unusual mortality event in the Indian River Lagoon. Front. Mar. Sci., 9.","DOI":"10.3389\/fmars.2022.841857"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1638\/1042-7260(2003)034[0184:MITCFM]2.0.CO;2","article-title":"Mycobacteriosis in two captive Florida manatees (Trichechus manatus latirostris)","volume":"34","author":"Sato","year":"2003","journal-title":"J. Zoo Wildl. Med."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Trancassini, M., Iebba, V., Citer\u00e0, N., Tuccio, V., Magni, A., Varesi, P., Biase, R., Totino, V., Santangelo, F., and Gagliardi, A. (2014). Outbreak of Achromobacter xylosoxidans in an Italian cystic fibrosis center: Genome variability, biofilm production, antibiotic resistance, and motility in isolated strains. Front. Microbiol., 5.","DOI":"10.3389\/fmicb.2014.00138"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e01025-20","DOI":"10.1128\/AAC.01025-20","article-title":"Achromobacter infections and treatment options","volume":"64","author":"Isler","year":"2020","journal-title":"Agents Chemother."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Chalhoub, H., Kampmeier, S., Kahl, B.C., and Van Bambeke, F. (2022). Role of efflux in antibiotic resistance of Achromobacter xylosoxidans and Achromobacter insuavis isolates from patients with cystic fibrosis. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.762307"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Nielsen, S.M., Penstoft, L.N., and N\u00f8rskov-Lauritsen, N. (2019). Motility, biofilm formation and antimicrobial efflux of sessile and planktonic cells of Achromobacter xylosoxidans. Pathogens, 8.","DOI":"10.3390\/pathogens8010014"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Lasfar, A. (2024). Immunosuppression in infectious diseases: Causes and effects. Innate Immunity\u2014New Perspectives and Therapeutic Opportunities, IntechOpen.","DOI":"10.5772\/intechopen.111143"},{"key":"ref_53","first-page":"2897","article-title":"Environmental aspects and diseases related to immunosuppression in cetaceans: A concise review","volume":"39","author":"Koch","year":"2018","journal-title":"Semina: Ci\u00eanc. Agr\u00e1r."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Marsili, L., Di Guardo, G., Mazzariol, S., and Casini, S. (2019). Insights into cetacean immunology: Do ecological and biological factors make the difference?. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01219"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"116848","DOI":"10.1016\/j.ecoenv.2024.116848","article-title":"Intersecting planetary health: Exploring the impacts of environmental stressors on wildlife and human health","volume":"283","author":"Chen","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7142","DOI":"10.1128\/AEM.02293-13","article-title":"Detection of Achromobacter xylosoxidans in hospital, domestic, and outdoor environmental samples and comparison with human clinical isolates","volume":"79","author":"Amoureux","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_57","first-page":"6374","article-title":"Nosocomial outbreak of Achromobacter spp. bacteremia due to germicide contamination: A systematic review","volume":"26","author":"Yoon","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Jakobsen, T.H., Hansen, M.A., Jensen, P.O., Hansen, L., Riber, L., Cockburn, A., Kolpen, M., Hansen, C.R., Ridderberg, W., and Eickhardt, S. (2013). Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068484"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40560-025-00794-y","article-title":"Disseminated intravascular coagulation","volume":"13","author":"Gando","year":"2025","journal-title":"J. Intensive Care"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1177\/1076029618806424","article-title":"Disseminated intravascular coagulation: An update on pathogenesis, diagnosis, and therapeutic strategies","volume":"24","author":"Papageorgiou","year":"2018","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"104206","DOI":"10.1016\/j.micpath.2020.104206","article-title":"Ocular bacterial infections: Pathogenesis and diagnosis","volume":"145","author":"Deepthi","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.18240\/ijo.2020.12.14","article-title":"Clinical features and treatment outcomes of endogenous Klebsiella endophthalmitis: A 12-year review","volume":"13","author":"Mak","year":"2020","journal-title":"Int. J. Ophthalmol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Wiedermann, C.J. (2021). Hypoalbuminemia as surrogate and culprit of infections. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094496"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Osorio, J.S. (2020). Gut health, stress, and immunity in neonatal dairy calves: The host side of host-pathogen interactions. J. Anim. Sci. Biotechnol., 11.","DOI":"10.1186\/s40104-020-00509-3"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Sedney, C.J., and Harvill, E.T. (2023). The neonatal immune system and respiratory pathogens. Microorganisms, 11.","DOI":"10.3390\/microorganisms11061597"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12959-023-00577-1","article-title":"Oxidative stress in acute pulmonary embolism: Emerging roles and therapeutic implications","volume":"22","author":"Yang","year":"2024","journal-title":"Thromb. J."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Wang, Q., and Zennadi, R. (2020). Oxidative stress and thrombosis during aging: The roles of oxidative stress in RBCs in venous thrombosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124259"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. 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