{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:39:14Z","timestamp":1760060354597,"version":"build-2065373602"},"reference-count":56,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"introduce talents and doctoral research of Shanxi Agricultural University","award":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"],"award-info":[{"award-number":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"],"award-info":[{"award-number":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"]}]},{"name":"Biological Breeding Project of Shanxi Agricultural University","award":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"],"award-info":[{"award-number":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"]}]},{"name":"Earmarked Fund for Modern Agro-industry Technology Research System of Shanxi Province","award":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"],"award-info":[{"award-number":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"]}]},{"name":"International Science and Technology Cooperation Program of the Ministry of Science and Technology of China","award":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"],"award-info":[{"award-number":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"]}]},{"name":"Shanxi Agricultural University Local Cooperation Project","award":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"],"award-info":[{"award-number":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"]}]},{"name":"Shanxi Key Laboratory of Animal Genetic Resources Utilization and Breeding","award":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"],"award-info":[{"award-number":["2023BQ08","202303021222081","YZGC133","2024QT155","SQ2023YFE0102235","XDHZYQFXY-07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Poly (I:C), a viral mimic, is capable of activating the antiviral immune mechanisms in teleosts. In this study, we investigated the transcriptional responses of Ussuri Catfish (Pseudobagrus ussuriensis) to poly (I:C) stimulation at 3 and 48 h, focusing on the similarities and differences in antiviral mechanisms exhibited in the liver and spleen. At 3 h, the signaling pathways that were concurrently enriched in both the spleen and liver include JAK-STAT, TNF, NF-\u03baB, RIG-I-like receptor, and NOD-like receptor. At 48 h, the signaling pathways that were concurrently enriched in both the spleen and liver include JAK-STAT signaling and cellular homeostasis processes. However, in the liver, the signaling pathways that responded to poly (I:C) stimulation at both 3 and 48 h are cytokine\u2013cytokine receptor interaction and RIG-I-like receptor signaling. In the spleen, the signaling pathways that responded to poly (I:C) stimulation at both 3 and 48 h are Hippo signaling, Wnt signaling, TGF-\u03b2 signaling, and ECM-receptor interaction. Ultimately, the pathways that were enriched in the intersection genes across all groups are JAK-STAT signaling, NK cell-mediated cytotoxicity, and ECM-receptor interaction, and the core genes identified in the intersection genes of all groups are PTPRS, HECW1, and ERN1 (IRE1), along with UMAD, DKK1, CSH, and RTKN2. Through this study, we identified the key signaling pathways and core genes involved in the antiviral response of Ussuri catfish. These findings provide valuable insights into the antiviral mechanisms of Ussuri catfish.<\/jats:p>","DOI":"10.3390\/ani15162454","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T14:46:04Z","timestamp":1755787564000},"page":"2454","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Transcriptomic Analysis of the Liver and Spleen in Ussuri Catfish (Pseudobagrus ussuriensis) Challenged with Polyriboinosinic Polyribocytidylic Acid (Poly(I:C))"],"prefix":"10.3390","volume":"15","author":[{"given":"Yu","family":"Liu","sequence":"first","affiliation":[{"name":"College of Animal Science, Shanxi Agricultural University, Jinzhong 030800, China"},{"name":"Shanxi Key Laboratory of Animal Genetics Resource Utilization and Breeding, Jinzhong 030800, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science, Shanxi Agricultural University, Jinzhong 030800, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Animal Science, Shanxi Agricultural University, Jinzhong 030800, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanhuan","family":"Miao","sequence":"additional","affiliation":[{"name":"College of Animal Science, Shanxi Agricultural University, Jinzhong 030800, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libo","family":"Gu","sequence":"additional","affiliation":[{"name":"College of Animal Science, Shanxi Agricultural University, Jinzhong 030800, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhipeng","family":"Dou","sequence":"additional","affiliation":[{"name":"College of Animal Science, Shanxi Agricultural University, Jinzhong 030800, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science, Shanxi Agricultural University, Jinzhong 030800, China"},{"name":"Shanxi Key Laboratory of Animal Genetics Resource Utilization and Breeding, Jinzhong 030800, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ortega-Villaizan, M.D.M., Chico, V., and Perez, L. 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