{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:26:18Z","timestamp":1784953578660,"version":"3.55.0"},"reference-count":45,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jiangxi Provincial Cultivation Program for Academic and Technical Leaders of Major Subjects","award":["No. 20213BCJ22005"],"award-info":[{"award-number":["No. 20213BCJ22005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study evaluated the effects of dietary potassium diformate supplementation on growth performance, nutrient digestibility, gastrointestinal pH, jejunal morphology, digestive enzyme activity, and antioxidant status of weaned piglets in a 28-day trial. Twenty-four weaned piglets were selected and, after a 4-day adaptation period, randomly assigned to 4 treatment groups (n = 6). The dietary treatments included a control diet (basal diet) and 3 diets supplemented with 0.6%, 1.2%, or 1.8% potassium diformate in the basal diet. The results indicated that the feed conversion ratio (FCR) of piglets was reduced by all three potassium diformate supplementation levels compared to the control group (p &lt; 0.05). Additionally, the FCR was decreased in piglets fed the 1.8% potassium diformate-supplemented diet compared to those fed the 1.2% potassium diformate-supplemented diet (p &lt; 0.05). Piglets fed the three potassium diformate-supplemented diets exhibited higher apparent total tract digestibility (ATTD) of dry matter and crude protein than the control group (p &lt; 0.05). The 1.8% potassium diformate groups also showed increased ATTD of calcium and phosphorus compared to the control group (p &lt; 0.05). Supplementation with 1.2% or 1.8% potassium diformate reduced the digesta pH in the proximal stomach, distal stomach, and duodenum, while increased jejunal villus height (VH), VH\/crypt depth (VH\/CD) ratio, and catalase and total superoxide dismutase activities in the jejunal mucosa compared to the control group (p &lt; 0.05). The 1.2% potassium diformate group showed higher \u03b1-amylase activity than the control group (p &lt; 0.05). Correlation analysis revealed that FCR negatively correlated with ATTD of dry matter, crude protein, calcium, phosphorus, and jejunal VH, while positively correlating with digesta pH in the proximal stomach (p &lt; 0.05). The ATTD of dry matter negatively correlated with digesta pH in the proximal stomach, distal stomach, and duodenum, and positively correlated with jejunal VH\/CD ratio and catalase activity (p &lt; 0.05). The ATTD of crude protein negatively correlated with digesta pH in the proximal stomach, distal stomach, and duodenum (p &lt; 0.05). Collectively, dietary supplementation with 1.8% potassium diformate reduced FCR of weaned piglets, which was associated with enhanced nutrient digestibility, reduced pH in the anterior gastrointestinal tract, and improved jejunal morphology.<\/jats:p>","DOI":"10.3390\/ani15192916","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T12:46:56Z","timestamp":1759841216000},"page":"2916","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Dietary Potassium Diformate Supplementation on Growth Performance, Nutrient Digestibility, Gastrointestinal pH, Jejunal Morphology, Digestive Enzyme Activity, and Antioxidant Status in Weaned Piglets"],"prefix":"10.3390","volume":"15","author":[{"given":"Lina","family":"Zhang","sequence":"first","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lu","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Zhong","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiande","family":"Zou","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingren","family":"Qu","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5037-3479","authenticated-orcid":false,"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"106316","DOI":"10.1016\/j.prevetmed.2024.106316","article-title":"Risk factors associated with piglet pre-weaning mortality in a Midwestern U.S. swine production system from 2020 to 2022","volume":"232","author":"Will","year":"2024","journal-title":"Prev. 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