{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T13:45:45Z","timestamp":1777038345505,"version":"3.51.4"},"reference-count":153,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This paper describes a detailed evaluation of published works, in which proteomics methodological approaches and technologies were used to advance knowledge about small ruminants. The specific objective of this assessment was the presentation of quantitative characteristics on the content and the bibliometric details of publications on the use of proteomics methodological approaches and technologies in small ruminant work. For the search of published papers, the following topical search string was used: [sheep OR ovine OR Ovis aries OR goat* OR caprine OR Capra hircus] AND [proteom*], in the Web of Science database. In total, 481 published papers (448 original articles and 33 reviews) were evaluated individually. These originated from 56 countries, mostly from China and the United States of America, and increased gradually with time. Most (85.7%) original articles presented experimental work with animals, most often in sheep\/goat production (37.4%) and reproduction (21.8%), and less often in physiology (19.0%) or diseases (17.9%). Tissues analyzed more often were milk (17.9%), blood (10.3%), and muscle (9.2%). The proteomics methodological approach and technology employed most frequently was the liquid chromatography-tandem mass spectrometry (52.9% of articles). The journal, in which papers were published most frequently, was the Journal of Proteomics (8.3%). There were 3689 authors in total in the published papers, with a median number of 7 per paper Median number of references was 50 per published paper. Median number of citations was eight per published paper, and median number of annual citations was 2.0 per published paper. Significant predictors for the number of annual citations were (a) for reviews, the number of references, and (b) for original articles, the number of references, the topic of study, and the animal species referred to in the articles. The Epimetre briefly reviews the contribution of proteomics in the health management of sheep and goats. Overall, the results have indicated that the use of proteomics methodological approaches and technologies in sheep and goat work has advanced our knowledge and understanding of the biology of these two animal species in a multitude of fields and topics internationally, with an increasing dissemination and applicability.<\/jats:p>","DOI":"10.3390\/ani15203050","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:24:02Z","timestamp":1761056642000},"page":"3050","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Appraisal of the Use of Proteomics Methodological Approaches and Technologies on Sheep and Goat Research and Clinical Work"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7417-7830","authenticated-orcid":false,"given":"Maria V.","family":"Bourganou","sequence":"first","affiliation":[{"name":"Faculty of Public and One Health, University of Thessaly, 43100 Karditsa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia A.","family":"Vaitsi","sequence":"additional","affiliation":[{"name":"Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1860-9115","authenticated-orcid":false,"given":"Dimitra V.","family":"Liagka","sequence":"additional","affiliation":[{"name":"Faculty of Animal Science, University of Thessaly, 41110 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalambia K.","family":"Michael","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, European University of Cyprus, Egkomi, Nicosia 2404, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni I.","family":"Katsarou","sequence":"additional","affiliation":[{"name":"Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitris C.","family":"Chatzopoulos","sequence":"additional","affiliation":[{"name":"Faculty of Public and One Health, University of Thessaly, 43100 Karditsa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia G. C.","family":"Vasileiou","sequence":"additional","affiliation":[{"name":"Faculty of Animal Science, University of Thessaly, 41110 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2564-5203","authenticated-orcid":false,"given":"Elias","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology and Parasitic Diseases, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-4758","authenticated-orcid":false,"given":"George Th.","family":"Tsangaris","sequence":"additional","affiliation":[{"name":"Proteomics Research Unit, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphne T.","family":"Lianou","sequence":"additional","affiliation":[{"name":"Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2353-0835","authenticated-orcid":false,"given":"Vasia S.","family":"Mavrogianni","sequence":"additional","affiliation":[{"name":"Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George C.","family":"Fthenakis","sequence":"additional","affiliation":[{"name":"Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9533-0093","authenticated-orcid":false,"given":"Angeliki I.","family":"Katsafadou","sequence":"additional","affiliation":[{"name":"Faculty of Public and One Health, University of Thessaly, 43100 Karditsa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1021\/acsmeasuresciau.3c00068","article-title":"Comprehensive overview of bottom-up proteomics using mass spectrometry","volume":"4","author":"Jiang","year":"2024","journal-title":"ACS Meas. 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