{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:18:00Z","timestamp":1779916680661,"version":"3.53.1"},"reference-count":83,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2021YFD1300403"],"award-info":[{"award-number":["2021YFD1300403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"crossref","award":["YQ2024C014"],"award-info":[{"award-number":["YQ2024C014"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Postdoctoral Natural Science Foundation of China","award":["2024MD763932"],"award-info":[{"award-number":["2024MD763932"]}]},{"name":"Postdoctoral Natural Science Foundation of Heilongjiang Province","award":["LBH-Z24083"],"award-info":[{"award-number":["LBH-Z24083"]}]},{"name":"Northeast Agricultural University Academic Backbone Project","award":["54960412"],"award-info":[{"award-number":["54960412"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Chronic cold stress is a severe test that animals in cold regions have to face during winter. However, the lack of precise dietary adjustments for animals in cold regions represents a significant gap in addressing their nutritional needs. Full-fat rice bran is one of the feed materials rich in protein, lipids, dietary fiber, and antioxidant-active substances. Glucose is the most common quick energy supply. We determined dietary full-fat rice bran and glucose can improve the growth and health of cold-exposed pigs. A total of 18 Yorkshire pigs were randomized to one of three treatment groups (basal diet, full-fat rice bran diet (20%), and glucose diet (10%)) for 22 d to evaluate the effects of full-fat rice bran and glucose on growth performance, antioxidants, microbiomes, and bile acid circulation in cold-exposed pigs. The results showed that dietary full-fat rice bran decreased the average daily feed intake (p &lt; 0.05), increased superoxide dismutase (SOD) activity in plasma (p &lt; 0.05), and decreased Rikenellaceae_RC9_gut_group and Campylobacter in the colon microbiota of cold-exposed pigs (p &lt; 0.05). Dietary glucose improved the growth performance of cold-exposed pigs and decreased the abundance of Prevotellaceae_NK3B31_group (p &lt; 0.05) in the colon microbiota of cold-exposed pigs. Dietary full-fat rice bran and glucose both downregulated the abundance of Alloprevotella, Bradymonadales, and Erysipelotrichaceae in colon microbiota (p &lt; 0.05), promoted the production of SCFAs, and activated the FXR-CYP7A1 signaling pathway. Dietary full-fat rice bran or glucose promoted fecal excretion of bile acids. This study demonstrated that dietary supplementation with full-fat rice bran or glucose can improve the colonic microbiota structure and SCFA levels in cold-exposed pigs. When comparing the two dietary strategies, the glucose-supplemented diet is more beneficial to the growth performance of cold-exposed pigs, while the full-fat-rice-bran-supplemented diet is more conducive to enhancing the function of their antioxidant system. Additionally, dietary supplementation with full-fat rice bran or glucose can also regulate the bile acid circulation in pigs, thereby enhancing their cold adaptation ability.<\/jats:p>","DOI":"10.3390\/ani15223232","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T11:41:47Z","timestamp":1762515707000},"page":"3232","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dietary Full-Fat Rice Bran or Glucose Regulates Bile Acid Circulation, Colonic Microbiota, and Short-Chain Fatty Acids in Pigs During Chronic Cold Stress"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7716-9172","authenticated-orcid":false,"given":"Yusong","family":"Zheng","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9655-0609","authenticated-orcid":false,"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6225-9910","authenticated-orcid":false,"given":"Guodong","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-5933","authenticated-orcid":false,"given":"Teng","family":"Teng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8560-4564","authenticated-orcid":false,"given":"Baoming","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e0505","DOI":"10.5424\/sjar\/2018162-12753","article-title":"Comparison of Growth Performance and Immune Responses of Broiler Chicks Reared Under Heat Stress, Cold Stress and Thermoneutral Conditions","volume":"16","author":"Mojtahedin","year":"2018","journal-title":"Span. 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