{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:44:58Z","timestamp":1790145898669,"version":"4.0.1"},"reference-count":29,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The objective of this study was to evaluate the effects of 25-hydroxy-vitamin D3 (25OHD3) supplementation on reproductive performance, nutrient digestibility, lameness score, milk composition, and blood profiles in sows, as well as the performance and blood profiles of their offspring. From day 110 of gestation to 21 days of weaning, a total of 30 multiparous sows (Landrace \u00d7 Yorkshire) were randomly assigned to one of three dietary treatments, with ten sows per treatment. The dietary treatments were: (1) CON, basal diet; (2) TRT1, CON diet plus 1114 IU 25OHD3\/kg (13.92 \u00b5g 25OHD3\/kg feed); and (3) TRT2, CON diet plus 2227 IU 25OHD3\/kg (27.84 \u00b5g 25OHD3\/kg feed). The reproduction performance and nutrient digestibility of sows were not affected by 25OHD3 supplementation. However, the inclusion of graded levels of 25OHD3 in the sow diet had significantly reduced their farrowing time (p &lt; 0.001) compared to those fed the CON diet. Also, sows fed 25OHD3 produced significantly higher (p &lt; 0.05) number of piglets compared to the CON group. Piglets from supplemented sows exhibited greater (p &lt; 0.05) average daily gain and weaning body weight. Moreover, colostrum protein content was higher (p &lt; 0.05) in sows fed 25OHD3 compared with the CON group. Similarly, the concentration of 25OHD3 in colostrum and milk at weaning was markedly (p &lt; 0.001) elevated. Furthermore, serum 25OHD3 levels were significantly higher (p &lt; 0.05) in both sows and piglets, and piglet serum immunoglobulin G (IgG) concentrations were also elevated (p &lt; 0.05) in the supplemented groups. In summary, dietary 25OHD3 in the sow diet not only improves their reproductive performance and milk quality but also enhances piglet growth, immunity, and overall vitality, suggesting that 25OHD3 is a valuable nutritional strategy for optimizing sow productivity and promoting healthier offspring.<\/jats:p>","DOI":"10.3390\/ani15223264","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T10:56:27Z","timestamp":1762858587000},"page":"3264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Supplementing 25-Hydroxy-Vitamin D3 to Sows Enhances Milk and Blood Parameters, with Extended Benefits to Their Offspring"],"prefix":"10.3390","volume":"15","author":[{"given":"Shanmugam","family":"Sureshkumar","sequence":"first","affiliation":[{"name":"Department of Animal Biotechnology, Dankook University, Anseodong, Cheonan 31116, Republic of Korea"},{"name":"Smart Animal Bio Institute, Dankook University, Cheonan 31116, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Raihanul","family":"Hoque","sequence":"additional","affiliation":[{"name":"Department of Animal Biotechnology, Dankook University, Anseodong, Cheonan 31116, Republic of Korea"},{"name":"Smart Animal Bio Institute, Dankook University, Cheonan 31116, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6652-2504","authenticated-orcid":false,"given":"In Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Biotechnology, Dankook University, Anseodong, Cheonan 31116, Republic of Korea"},{"name":"Smart Animal Bio Institute, Dankook University, Cheonan 31116, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Patterson, J., and Foxcroft, G. 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