{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T11:21:33Z","timestamp":1763724093094,"version":"3.45.0"},"reference-count":40,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Background: The prognostic use of both the echocardiographic parameters tricuspid annular plane systolic excursion (TAPSE) and systolic pulmonary artery pressure (sPAP) in dogs with pulmonary hypertension (PH) has shown conflicting results. The ratio of TAPSE\/sPAP, not yet described in dogs, is used for the evaluation and risk assessment in people with PH and is a validated surrogate for right ventricular to pulmonary artery coupling with lower values being associated with poor outcome. This study aimed to describe TAPSE\/sPAP in dogs with precapillary PH (PCPH) due to various diseases. It demonstrates the correlation of this ratio with echocardiographic indices, its association with heart failure (HF) and its prognostic value. Methods: Medical records and echocardiographic data from 95 client-owned dogs with estimated mild (n = 10), moderate (n = 31) or severe (n = 54) PCPH were retrospectively reviewed. Body weight-independent TAPSE\/sPAP ratios were obtained, and short-term and overall survival until death from all causes or cardio-pulmonary death (CPD) were assessed. Results: TAPSE\/sPAP was lower in dogs with HF and correlated with other echocardiographic variables commonly altered in dogs with PCPH. Different TAPSE\/sPAP ratios, such as nTAPSE\/(sPAP(m\/s)), were independent predictors of short-term CPD, as was having pulmonary thromboembolism. For overall survival only HF was a risk factor of CPD. The cut-off value of &lt;1.05 for nTAPSE\/(sPAP(m\/s)) was associated with shorter survival for dogs dying from CPD. Conclusions: The TAPSE\/sPAP ratio is a non-invasive echocardiographic parameter that provides prognostic information, especially in short-term survival, in dogs with PCPH and may aid in risk stratification.<\/jats:p>","DOI":"10.3390\/ani15233365","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T11:04:31Z","timestamp":1763723071000},"page":"3365","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Body Weight-Independent Tricuspid Annular Plane Systolic Excursion to Systolic Pulmonary Arterial Pressure Ratio in Canine Precapillary Pulmonary Hypertension: A Retrospective Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8846-2119","authenticated-orcid":false,"given":"Emilie","family":"Van Renterghem","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9959-1952","authenticated-orcid":false,"given":"Margaux","family":"Legrand","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marine","family":"Lekane","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-8010","authenticated-orcid":false,"given":"Elodie","family":"Roels","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7706-2502","authenticated-orcid":false,"given":"Kris","family":"Gommeren","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-6336","authenticated-orcid":false,"given":"Anne-Christine","family":"Merveille","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/jvim.15725","article-title":"ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs","volume":"34","author":"Reinero","year":"2020","journal-title":"J. Vet. Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e009047","DOI":"10.1161\/CIRCIMAGING.119.009047","article-title":"Validation of the Tricuspid Annular Plane Systolic Excursion\/Systolic Pulmonary Artery Pressure Ratio for the Assessment of Right Ventricular-Arterial Coupling in Severe Pulmonary Hypertension","volume":"12","author":"Tello","year":"2019","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijcard.2018.01.053","article-title":"Relevance of the TAPSE\/PASP ratio in pulmonary arterial hypertension","volume":"266","author":"Tello","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1111\/jvim.15826","article-title":"Survival characteristics and prognostic importance of echocardiographic measurements of right heart size and function in dogs with pulmonary hypertension","volume":"34","author":"Visser","year":"2020","journal-title":"J. Vet. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.healun.2022.09.005","article-title":"Interest of TAPSE\/sPAP ratio for noninvasive pulmonary arterial hypertension risk assessment","volume":"41","author":"Fauvel","year":"2022","journal-title":"J. Heart Lung Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.4142\/jvs.2019.20.e34","article-title":"Prognostic value of right pulmonary artery distensibility in dogs with pulmonary hypertension","volume":"20","author":"Chan","year":"2019","journal-title":"J. Vet. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"105347","DOI":"10.1016\/j.tvjl.2019.105347","article-title":"Pulmonary hypertension secondary to respiratory disease and\/or hypoxia in dogs: Clinical features, diagnostic testing and survival","volume":"251","author":"Jaffey","year":"2019","journal-title":"Vet. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/j.1939-1676.2012.00981.x","article-title":"Tricuspid annular plane systolic excursion (TAPSE) in dogs: Reference values and impact of pulmonary hypertension","volume":"26","author":"Pariaut","year":"2012","journal-title":"J. Vet. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1111\/jvim.15253","article-title":"Echocardiographic evaluation of the right ventricular dimension and systolic function in dogs with pulmonary hypertension","volume":"32","author":"Vezzosi","year":"2018","journal-title":"J. Vet. Intern. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jvc.2014.10.004","article-title":"Accuracy of Doppler echocardiographic estimates of pulmonary artery pressures in a canine model of pulmonary hypertension","volume":"17","author":"Soydan","year":"2015","journal-title":"J. Vet. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.echo.2025.01.006","article-title":"Guidelines for the Echocardiographic Assessment of the Right Heart in Adults and Special Considerations in Pulmonary Hypertension: Recommendations from the American Society of Echocardiography","volume":"38","author":"Mukherjee","year":"2025","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/jvim.15984","article-title":"Utility of tricuspid annular plane systolic excursion normalized by right ventricular size indices in dogs with postcapillary pulmonary hypertension","volume":"35","author":"Yuchi","year":"2021","journal-title":"J. Vet. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jvc.2017.03.007","article-title":"Tricuspid annular plane systolic excursion in dogs with myxomatous mitral valve disease with and without pulmonary hypertension","volume":"19","author":"Poser","year":"2017","journal-title":"J. Vet. Cardiol."},{"key":"ref_15","first-page":"311","article-title":"Allometric scaling of M-mode cardiac measurements in normal adult dogs","volume":"18","author":"Cornell","year":"2004","journal-title":"J. Vet. Intern. Med."},{"key":"ref_16","first-page":"429","article-title":"Evaluation of four 2-dimensional echocardiographic methods of assessing left atrial size in dogs","volume":"14","author":"Rishniw","year":"2000","journal-title":"J. Vet. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1939-1676.1993.tb01015.x","article-title":"Recommendations for standards in transthoracic two-dimensional echocardiography in the dog and cat. Echocardiography Committee of the Specialty of Cardiology, American College of Veterinary Internal Medicine","volume":"7","author":"Thomas","year":"1993","journal-title":"J. Vet. Intern. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.cvsm.2010.03.011","article-title":"Pulmonary hypertension in dogs: Diagnosis and therapy","volume":"40","author":"Kellihan","year":"2010","journal-title":"Vet. Clin. North. Am. Small Anim. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/ejechocard\/jeq031","article-title":"European Association of Echocardiography recommendations for the assessment of valvular regurgitation. Part 2: Mitral and tricuspid regurgitation (native valve disease)","volume":"11","author":"Lancellotti","year":"2010","journal-title":"Eur. J. Echocardiogr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1740-8261.2005.00062.x","article-title":"Assessment of cardiac chamber size using anatomic M-mode","volume":"46","author":"Oyama","year":"2005","journal-title":"Vet. Radiol. Ultrasound"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/jvim.16331","article-title":"Echocardiographic reference intervals for right ventricular indices, including 3-dimensional volume and 2-dimensional strain measurements in healthy dogs","volume":"36","author":"Feldhutter","year":"2022","journal-title":"J. Vet. Intern. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jvc.2018.01.005","article-title":"Tricuspid annular plane systolic excursion-to-aortic ratio provides a bodyweight-independent measure of right ventricular systolic function in dogs","volume":"20","author":"Caivano","year":"2018","journal-title":"J. Vet. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jvc.2016.05.002","article-title":"Conventional echocardiographic assessment of the canine right heart: Reference intervals and repeatability","volume":"18","author":"Abbott","year":"2016","journal-title":"J. Vet. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jvc.2023.12.003","article-title":"Left ventricular eccentricity index to assess precapillary pulmonary hypertension in dogs","volume":"51","author":"Lekane","year":"2024","journal-title":"J. Vet. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jvc.2014.10.003","article-title":"Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs: Repeatability and reference intervals","volume":"17","author":"Visser","year":"2015","journal-title":"J. Vet. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jvc.2023.09.003","article-title":"Echocardiographic reference intervals of the dimensions of the main pulmonary artery and the right pulmonary artery: A prospective study in 269 healthy dogs","volume":"50","author":"Grosso","year":"2023","journal-title":"J. Vet. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jvc.2019.06.001","article-title":"Diagnostic value of the pulmonary vein-to-right pulmonary artery ratio in dogs with pulmonary hypertension of precapillary origin","volume":"24","author":"Roels","year":"2019","journal-title":"J. Vet. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1213\/ANE.0000000000002864","article-title":"Correlation Coefficients: Appropriate Use and Interpretation","volume":"126","author":"Schober","year":"2018","journal-title":"Anesth. Analg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"479","DOI":"10.14744\/AnatolJCardiol.2024.4110","article-title":"Prognostic Impact of the Tricuspid Annular Plane Systolic Excursion\/Pulmonary Arterial Systolic Pressure Ratio in Acute Pulmonary Embolism","volume":"28","author":"Kultursay","year":"2024","journal-title":"Anatol. J. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1476-7120-7-51","article-title":"Predictors of right ventricular function as measured by tricuspid annular plane systolic excursion in heart failure","volume":"7","author":"Kjaergaard","year":"2009","journal-title":"Cardiovasc. Ultrasound"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kazimierczyk, R., Kazimierczyk, E., Knapp, M., Sobkowicz, B., Malek, L.A., Blaszczak, P., Ptaszynska-Kopczynska, K., Grzywna, R., and Kaminski, K.A. (2021). Echocardiographic Assessment of Right Ventricular-Arterial Coupling in Predicting Prognosis of Pulmonary Arterial Hypertension Patients. J. Clin. Med., 10.","DOI":"10.3390\/jcm10132995"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1111\/jvim.16496","article-title":"Right ventricular size and function evaluated by various echocardiographic indices in dogs with pulmonary hypertension","volume":"36","author":"Feldhutter","year":"2022","journal-title":"J. Vet. Intern. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/ehf2.13726","article-title":"Right ventricular function and its coupling to pulmonary circulation predicts exercise tolerance in systolic heart failure","volume":"9","author":"Legris","year":"2022","journal-title":"ESC Heart Fail."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/ejhf.664","article-title":"Different correlates but similar prognostic implications for right ventricular dysfunction in heart failure patients with reduced or preserved ejection fraction","volume":"19","author":"Ghio","year":"2017","journal-title":"Eur. J. Heart Fail."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"de Pinto, M., Coppi, F., Spinella, A., Pagnoni, G., Morgante, V., Macripo, P., Boschini, M., Guerra, A.F., Tampieri, F., and Secchi, O. (2024). The predictive role of the TAPSE\/sPAP ratio for cardiovascular events and mortality in systemic sclerosis with pulmonary hypertension. Front. Cardiovasc. Med., 11.","DOI":"10.3389\/fcvm.2024.1430903"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10741-023-10341-2","article-title":"The prognostic impact of right ventricular-pulmonary arterial coupling in heart failure: A systematic review and meta-analysis","volume":"29","author":"Anastasiou","year":"2024","journal-title":"Heart Fail. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Vicenzi, M., Caravita, S., Rota, I., Casella, R., Deboeck, G., Beretta, L., Lombi, A., and Vachiery, J.L. (2022). The added value of right ventricular function normalized for afterload to improve risk stratification of patients with pulmonary arterial hypertension. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0265059"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"334","DOI":"10.5606\/tgkdc.dergisi.2022.23218","article-title":"Prognostic value of TAPSE\/PASP ratio in right ventricular failure after left ventricular assist device implantation: Experience from a tertiary center","volume":"30","author":"Sert","year":"2022","journal-title":"Turk. Gogus Kalp Damar Cerrahisi Derg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/echo.12912","article-title":"Impact of Severe Tricuspid Regurgitation on Accuracy of Echocardiographic Pulmonary Artery Systolic Pressure Estimation","volume":"32","author":"Ozpelit","year":"2015","journal-title":"Echocardiography"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/echo.13555","article-title":"Impact of severe tricuspid regurgitation on accuracy of systolic pulmonary arterial pressure measured by Doppler echocardiography: Analysis in an unselected patient population","volume":"34","author":"Fei","year":"2017","journal-title":"Echocardiography"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/15\/23\/3365\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T11:17:40Z","timestamp":1763723860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/15\/23\/3365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":40,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["ani15233365"],"URL":"https:\/\/doi.org\/10.3390\/ani15233365","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,21]]}}}