{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T16:16:02Z","timestamp":1767716162662,"version":"3.48.0"},"reference-count":66,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003663","name":"Ministry of SMEs and Startups (MSS), Republic of Korea","doi-asserted-by":"publisher","award":["RS-2024-00468832"],"award-info":[{"award-number":["RS-2024-00468832"]}],"id":[{"id":"10.13039\/501100003663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003663","name":"Ministry of SMEs and Startups (MSS), Republic of Korea","doi-asserted-by":"publisher","award":["RS-2024-00508846"],"award-info":[{"award-number":["RS-2024-00508846"]}],"id":[{"id":"10.13039\/501100003663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gwangju RISE Center","award":["2025-RISE-05-011"],"award-info":[{"award-number":["2025-RISE-05-011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Obesity and metabolic disorders are an increasing concern in companion animals, creating demand for herb-derived nutraceuticals and functional feeds. This study evaluated whether a water extract of Aster pekinensis (AP) ameliorates high-fat-diet (HFD)-induced obesity and metabolic dysfunction in mice. The phytochemical profile of AP was characterized by mass spectrometry, revealing oleanane-type triterpenoid saponins and dicaffeoylquinic acids. Male C57BL\/6 mice were fed an HFD and orally given AP (10\u2013200 mg\/kg\/day) for 12 weeks, with normal diet and untreated HFD groups as controls. AP at 50\u2013200 mg\/kg\/day reduced body-weight gain, adipose tissue mass and food efficiency without lowering food intake, and improved fasting glucose and atherogenic lipid indices. AP also enhanced glucose tolerance and insulin sensitivity, attenuated hepatic steatosis, hepatocellular ballooning, lobular inflammation and non-alcoholic fatty liver disease (NAFLD) Activity Score, and decreased serum liver enzyme activities. These effects were accompanied by modulation of hepatic genes involved in lipogenesis and inflammation. Together, these findings indicate that AP extract mitigates diet-induced obesity and NAFLD-like liver injury and supports further development as a herb-derived nutraceutical or functional feed ingredient for managing obesity-related metabolic disorders in companion animals.<\/jats:p>","DOI":"10.3390\/ani16020163","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T16:12:55Z","timestamp":1767715975000},"page":"163","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aster pekinensis Extract Mitigates High-Fat-Diet-Induced Obesity and Metabolic Dysfunction in Mice"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0943-9297","authenticated-orcid":false,"given":"Hyeon Jeong","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon-Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea"},{"name":"Department of Integrative Food, Bioscience and Biotechnology, Graduate School of Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geon Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"TWELL Inc., Yeongcheon 38882, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1703-7742","authenticated-orcid":false,"given":"Yeong-Bin","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-0324","authenticated-orcid":false,"given":"Sang-Ik","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jcpa.2017.03.006","article-title":"Obesity and Associated Comorbidities in People and Companion Animals: A One Health Perspective","volume":"156","author":"Chandler","year":"2017","journal-title":"J. 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