{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:06:10Z","timestamp":1769202370409,"version":"3.49.0"},"reference-count":92,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AICanceR\u221eHub project","award":["NORTE2030-FEDER-02687800"],"award-info":[{"award-number":["NORTE2030-FEDER-02687800"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This retrospective study describes the national histopathology caseload of feline tumours submitted to a Portuguese diagnostic laboratory over a five-year period. A total of 1904 histopathology-confirmed neoplasms were analysed by biological behaviour, anatomical location, and demographic\/geographical variables. Malignant tumours predominated (77.4%), whereas 22.6% were benign. Tumours most commonly involved the mammary gland (44.8%) and cutaneous\/soft tissues (42.4%), together accounting for 87.2% of cases; all other sites were individually uncommon (\u22645.6%). The most frequent malignant tumour types were mammary carcinoma (38.3%), fibrosarcoma (8.0%), squamous cell carcinoma (6.4%), and mast cell tumour (4.8%). Cats with malignant tumours were older than those with benign lesions (p &lt; 0.001), and females comprised most submissions (69.3%), largely driven by mammary neoplasia. Multiple, histologically distinct tumours were identified in 8.3% of cats and were more frequent in older females (p = 0.001). Domestic Shorthairs comprised the vast majority of cases, and no significant associations were detected between breed (including pure breeds) or geographical location and tumour occurrence or biological behaviour (p &gt; 0.05). These findings highlight a sustained predominance of malignant disease in Portuguese cats, concentrated in mammary and cutaneous\/soft-tissue sites, supporting a low threshold for biopsy in older cats and systematic mammary screening in females, and continued registry-based surveillance to monitor temporal changes in tumour patterns.<\/jats:p>","DOI":"10.3390\/ani16030364","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T17:52:38Z","timestamp":1769190758000},"page":"364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping Feline Oncology in Portugal: A National Characterization"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-2041","authenticated-orcid":false,"given":"Paula","family":"Brilhante-Sim\u00f5es","sequence":"first","affiliation":[{"name":"INNO Veterinary Laboratories, R. C\u00e2ndido de Sousa 15, 4710-300 Braga, Portugal"},{"name":"Department of Veterinary and Animal Sciences, University Institute of Health Sciences (IUCS), CESPU, 4585-116 Gandra, Portugal"},{"name":"Department of Veterinary Sciences, University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-9932","authenticated-orcid":false,"given":"Ricardo","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences, University Institute of Health Sciences (IUCS), CESPU, 4585-116 Gandra, Portugal"},{"name":"Department of Veterinary Sciences, University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"},{"name":"CEDIVET Veterinary Laboratories, Lionesa Business Hub, R. Lionesa 446 C24, 4465-671 Le\u00e7a do Balio, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-0240","authenticated-orcid":false,"given":"Leonor","family":"Delgado","sequence":"additional","affiliation":[{"name":"INNO Veterinary Laboratories, R. C\u00e2ndido de Sousa 15, 4710-300 Braga, Portugal"},{"name":"Department of Veterinary and Animal Sciences, University Institute of Health Sciences (IUCS), CESPU, 4585-116 Gandra, Portugal"},{"name":"UNIPRO-Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), CESPU, 4585-116 Gandra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3992-3771","authenticated-orcid":false,"given":"Augusto","family":"Silva","sequence":"additional","affiliation":[{"name":"INNO Veterinary Laboratories, R. C\u00e2ndido de Sousa 15, 4710-300 Braga, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2399-5261","authenticated-orcid":false,"given":"Fernando","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Chemistry Research Centre, University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5502-5991","authenticated-orcid":false,"given":"Ricardo","family":"Marcos","sequence":"additional","affiliation":[{"name":"Cytology and Hematology Diagnostic Services, Laboratory of Histology and Embryology, Department of Microscopy, ICBAS-School of Medicine and Biomedical Sciences, University of Porto (U.Porto), Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"},{"name":"Animal Morphology and Toxicology Team, CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto (U.Porto), 4450-208 Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6130-8381","authenticated-orcid":false,"given":"Felisbina","family":"Queiroga","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"},{"name":"Animal and Veterinary Research Centre (CECAV), Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3902-5374","authenticated-orcid":false,"given":"Justina","family":"Prada","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"},{"name":"Animal and Veterinary Research Centre (CECAV), Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), University of Tr\u00e1s-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"ref_1","first-page":"111","article-title":"Cats, Cancer and Comparative Oncology","volume":"2","author":"Cannon","year":"2015","journal-title":"Vet. 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