{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T03:16:44Z","timestamp":1770175004262,"version":"3.49.0"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DIESSE Diagnostica Senese S.p.A.","award":["15506"],"award-info":[{"award-number":["15506"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Accurate early prognostic assessment is a central aspect of clinical decision-making in horses presenting with colic. Despite the availability of multiple clinical and laboratory parameters, reliable biomarkers that provide useful information at the time of admission remain limited. The erythrocyte sedimentation rate is a non-specific indicator of systemic inflammation that has recently been validated for automated point-of-care use in horses. Its behaviour in equine colic has not been previously characterised. This study included 85 horses admitted for colic at two university referral hospitals. The erythrocyte sedimentation rate was measured at admission in all horses and again approximately 24 h after surgery in a subset of surgical cases. Horses were classified as medically managed, surgical survivors or surgical non-survivors. Group comparisons were performed using non-parametric statistical methods, and associations with survival were evaluated. The admission erythrocyte sedimentation rate was significantly lower in surgical non-survivors compared to the other groups (p &lt; 0.05). Erythrocyte sedimentation rate rose in surviving horses within 24 h, while it barely changed among non-survivors, and there were no significant changes among surgical values. Actually, these observations suggest that low erythrocyte sedimentation rates on admission are associated with low chances of survival for horses undergoing colic surgery and thus make these rates a feasible additional prognostic indicator for equine colic.<\/jats:p>","DOI":"10.3390\/ani16030476","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T13:58:49Z","timestamp":1770127129000},"page":"476","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Significance of Erythrocyte Sedimentation Rate for Survival in Equine Colic"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1814-0688","authenticated-orcid":false,"given":"Federica","family":"Meistro","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell\u2019Emilia, BO, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4997-2340","authenticated-orcid":false,"given":"Riccardo","family":"Rinnovati","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell\u2019Emilia, BO, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0889-6337","authenticated-orcid":false,"given":"Edoardo","family":"Blanc","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126 Parma, PR, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0463-0611","authenticated-orcid":false,"given":"Priscilla","family":"Berni","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126 Parma, PR, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Napoli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126 Parma, PR, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Marcucci","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell\u2019Emilia, BO, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell\u2019Emilia, BO, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126 Parma, PR, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0936-720X","authenticated-orcid":false,"given":"Alessandro","family":"Spadari","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell\u2019Emilia, BO, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1803-1513","authenticated-orcid":false,"given":"Rodolfo","family":"Gialletti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126 Parma, PR, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/vr.j4161","article-title":"Equine colic: Putting the puzzle together","volume":"181","author":"Archer","year":"2017","journal-title":"Vet. Rec."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tvjl.2005.04.002","article-title":"Epidemiological clues to preventing colic","volume":"172","author":"Archer","year":"2006","journal-title":"Vet. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.2042-3306.1992.tb02789.x","article-title":"A two-year prospective survey of equine colic in general practice","volume":"24","author":"Proudman","year":"1992","journal-title":"Equine Vet. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.51585\/gjvr.2023.4.0063","article-title":"A review on equine colic: Etiology, differential diagnosis, therapy, and prevention","volume":"3","author":"Fereig","year":"2023","journal-title":"Ger. J. Vet. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.2042-3306.1997.tb03150.x","article-title":"What really causes colic in horses? Epidemiology\u2019s role in elucidating the ultimate multi-factorial disease","volume":"29","author":"Reeves","year":"1997","journal-title":"Equine Vet. J."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Matthews, L.B., Sanz, M., and Sellon, D.C. (2023). Long-term outcome after colic surgery: A retrospective study of 106 horses in the USA (2014\u20132021). Front. Vet. Sci., 10.","DOI":"10.3389\/fvets.2023.1235198"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/evj.12635","article-title":"Factors associated with survival of horses following relaparotomy","volume":"49","author":"Findley","year":"2017","journal-title":"Equine Vet. J."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Spadari, A., Gialletti, R., Gandini, M., Valle, E., Cerullo, A., Cavallini, D., Bertoletti, A., Rinnovati, R., Forni, G., and Scilimati, N. (2023). Short-term survival and postoperative complication rates in horses undergoing colic surgery: A multicentre study. Animals, 13.","DOI":"10.3390\/ani13061107"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/evj.13881","article-title":"Occurrence and definitions of postoperative complications in equine colic surgery: A scoping review","volume":"55","author":"Gandini","year":"2023","journal-title":"Equine Vet. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1751-0147-45-109","article-title":"Evaluation of clinical and laboratory variables as prognostic indicators in hospitalized horses with gastrointestinal colic","volume":"45","author":"Ihler","year":"2004","journal-title":"Acta Vet. Scand."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.5455\/OVJ.2024.v14.i8.8","article-title":"Prognostic importance of physiological and biochemical parameters in horses afflicted with colic","volume":"14","year":"2024","journal-title":"Open Vet. J."},{"key":"ref_12","first-page":"1116","article-title":"Equine colic: Sonographic evaluation, diagnostic criteria, and management of different categories","volume":"15","author":"Tharwat","year":"2025","journal-title":"Open Vet. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cveq.2023.03.007","article-title":"Early identification of intestinal strangulation: Why it is important and how to make an early diagnosis","volume":"39","author":"Southwood","year":"2023","journal-title":"Vet. Clin. N. Am. Equine Pract."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/evj.13977","article-title":"Use of multiple admission variables better predicts intestinal strangulation in horses with colic than peritoneal or the ratio of peritoneal-to-blood L-lactate concentration","volume":"56","author":"Long","year":"2024","journal-title":"Equine Vet. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1532-950X.2011.00859.x","article-title":"Peritoneal and plasma D-lactate concentrations in horses with colic","volume":"40","author":"Yamout","year":"2011","journal-title":"Vet. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e13210","DOI":"10.1590\/1678-4162-13210","article-title":"Blood and peritoneal lactate in equine colic: Application in emergency care and construction of a decision tree","volume":"76","author":"Barros","year":"2024","journal-title":"Arq. Bras. Med. Vet. Zootec."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cveq.2019.12.005","article-title":"Equine inflammatory markers in the twenty-first century: A focus on serum amyloid A","volume":"36","author":"Long","year":"2020","journal-title":"Vet. Clin. N. Am. Equine Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/vec.12504","article-title":"Acute-phase proteins as diagnostic markers in horses with colic","volume":"26","author":"Pihl","year":"2016","journal-title":"J. Vet. Emerg. Crit. Care"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ludwig, E.K., Hobbs, K.J., McKinney-Aguirre, C.A., and Gonzalez, L.M. (2023). Biomarkers of intestinal injury in equine colic. Animals, 13.","DOI":"10.3390\/ani13020227"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00007611-199803000-00001","article-title":"The erythrocyte sedimentation rate: Old and new clinical applications","volume":"91","author":"Saadeh","year":"1998","journal-title":"South. Med. J."},{"key":"ref_21","first-page":"1443","article-title":"Clinical utility of the erythrocyte sedimentation rate","volume":"60","author":"Brigden","year":"1999","journal-title":"Am. Fam. Physician"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Diamanti, D., Pieroni, C., Pennisi, M.G., Marchetti, V., Gori, E., Paltrinieri, S., and Lubas, G. (2025). The erythrocyte sedimentation rate in veterinary medicine: A focused review in dogs and cats. Animals, 15.","DOI":"10.3390\/ani15020246"},{"key":"ref_23","first-page":"386","article-title":"Erythrocyte sedimentation rate studies in sheep, dog, and horse","volume":"61","author":"Osbaldiston","year":"1971","journal-title":"Cornell Vet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e26911326416","DOI":"10.33448\/rsd-v11i3.26416","article-title":"Diagnostic efficacy of erythrocyte sedimentation rate in horses: An integrative systematic review","volume":"11","author":"Benvenutti","year":"2022","journal-title":"Res. Soc. Dev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9965095","DOI":"10.1155\/2023\/9965095","article-title":"Analytical validation of MINI-PET as a point-of-care for erythrocyte sedimentation rate measure in horses","volume":"2023","author":"Pieroni","year":"2023","journal-title":"Vet. Med. Int."},{"key":"ref_26","first-page":"6","article-title":"Erythrocyte sedimentation rate and C-reactive protein measurements and their relevance in clinical medicine","volume":"113","author":"Yale","year":"2014","journal-title":"WMJ"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1939-1676.1991.tb00944.x","article-title":"Endotoxemia in horses: A review of cellular and humoral mediators involved in its pathogenesis","volume":"5","author":"Morris","year":"1991","journal-title":"J. Vet. Intern. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cveq.2014.04.003","article-title":"Is it the systemic inflammatory response syndrome or endotoxemia in horses with colic?","volume":"30","author":"Moore","year":"2014","journal-title":"Vet. Clin. N. Am. Equine Pract."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1136\/vr.122.14.329","article-title":"Relationships between the erythrocyte sedimentation rate, plasma proteins and viscosity, and leucocyte counts in Thoroughbred racehorses","volume":"122","author":"Allen","year":"1988","journal-title":"Vet. Rec."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.2460\/javma.1992.200.12.1903","article-title":"Endotoxemia and septicemia in horses: Experimental and clinical correlates","volume":"200","author":"Moore","year":"1992","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_31","first-page":"857","article-title":"Clinical, hematological, and biochemical analysis of experimental endotoxemia in Thoroughbred horses","volume":"65","author":"Oikawa","year":"2003","journal-title":"J. Vet. Med. Sci."},{"key":"ref_32","first-page":"1023","article-title":"Equine endotoxemia: Pathomorphological aspects of endotoxin-induced damage in equine mesenteric arteries","volume":"59","author":"Oikawa","year":"1997","journal-title":"J. Vet. Med. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sheats, M.K. (2019). A comparative review of equine SIRS, sepsis, and neutrophils. Front. Vet. Sci., 6.","DOI":"10.3389\/fvets.2019.00069"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/3\/476\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T14:04:17Z","timestamp":1770127457000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/3\/476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["ani16030476"],"URL":"https:\/\/doi.org\/10.3390\/ani16030476","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,3]]}}}