{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:00:15Z","timestamp":1770746415377,"version":"3.49.0"},"reference-count":70,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Research and Development Project of Naqu City Science and Technology Bureau","award":["NQKJ-2023-07"],"award-info":[{"award-number":["NQKJ-2023-07"]}]},{"name":"Southwest Minzu University Gongga Project","award":["XNMDGG001"],"award-info":[{"award-number":["XNMDGG001"]}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"crossref","award":["2025ZNSFSC0979"],"award-info":[{"award-number":["2025ZNSFSC0979"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds for the Central Universities of Southwest Minzu University","award":["2023NYXXS008"],"award-info":[{"award-number":["2023NYXXS008"]}]},{"name":"Fundamental Research Funds for the Central Universities of Southwest Minzu University","award":["ZYN2023095"],"award-info":[{"award-number":["ZYN2023095"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The yak (Bos grunniens) thrives under chronic hypoxia and cold on the Qinghai\u2013Tibet Plateau, yet a cross-tissue view of post-transcriptional regulation in this species remains limited. Here, we integrated multi-tissue RNA-seq and miRNA-seq data (tissues pooled from three Maiwa yaks) to construct and compare tissue-specific competing endogenous RNA (ceRNA) networks, while explicitly addressing a major source of false positives in ceRNA inference\u2014misclassified lncRNA candidates with translational signatures. We cataloged 10,037 high-confidence lncRNAs (9360 non-redundant), 234 circRNAs, and 1030 miRNAs across six tissues. We then used Ribo-seq as an orthogonal quality-control layer to remove lncRNA candidates showing clear ribosome-association signals prior to network construction. Using a shared-target strategy (7mer-m8 seed matches; a ceRNA edge required \u22655 shared miRNAs), we assembled ceRNA networks for liver, lung, spleen, testis, and small intestine; skeletal muscle was excluded owing to insufficient Ribo-seq support for consistent filtering. Network topology varied substantially across tissues, with the testis network exhibiting the highest connectivity. ceRNA edges showed minimal overlap between tissues, indicating strong tissue dependence, whereas miRNA load\/use profiles were moderately concordant, supporting a hierarchical conserved core\u2014variable periphery organization. Importantly, the Ribo-seq\u2013filtered lncRNA set provides a separate pool of ribosome-associated candidates for targeted follow-up, although ribosome association alone does not establish stable micropeptide production. Together, our results deliver a multi-tissue ceRNA resource and a reproducible, evidence-aware workflow for prioritizing candidate regulators while reducing annotation-driven false positives in yak.<\/jats:p>","DOI":"10.3390\/ani16040532","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T12:42:42Z","timestamp":1770640962000},"page":"532","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Multi-Tissue Yak (Bos grunniens) ceRNA Atlas with Ribo-Seq\u2013Informed lncRNA Curation and Candidate Prioritization"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4924-9690","authenticated-orcid":false,"given":"Zhenlin","family":"Zhu","sequence":"first","affiliation":[{"name":"Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education and Sichuan Province, Southwest Minzu University, Chengdu 610041, China"},{"name":"College of Animal Science and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education and Sichuan Province, Southwest Minzu University, Chengdu 610041, China"},{"name":"College of Animal Science and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingfeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education and Sichuan Province, Southwest Minzu University, Chengdu 610041, China"},{"name":"College of Animal Science and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ayalew, W., Chu, M., Liang, C., Wu, X., and Yan, P. (2021). Adaptation mechanisms of yak (Bos grunniens) to high-altitude environmental stress. Animals, 11.","DOI":"10.3390\/ani11082344"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Naz, S., Chatha, A.M.M., Ullah, Q., Farooq, M., Jamil, T., Muner, R.D., and Kiran, A. (2025). Genomic adaptation, environmental challenges, and sustainable yak husbandry in high-altitude pastoral systems. Vet. Sci., 12.","DOI":"10.3390\/vetsci12080714"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1038\/s41598-019-43773-8","article-title":"Transcriptome profiles revealed the mechanisms underlying the adaptation of yak to high-altitude environments","volume":"9","author":"Xin","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e3959","DOI":"10.7717\/peerj.3959","article-title":"Comparative analysis of the microRNA transcriptome between yak and cattle provides insight into high-altitude adaptation","volume":"5","author":"Guan","year":"2017","journal-title":"PeerJ"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/s41598-025-30526-z","article-title":"Effective energy harvesting of Yak by regulating the glucose and lipid metabolism in liver to adapt to the plateau environment","volume":"16","author":"Ma","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_6","first-page":"100968","article-title":"Comparative proteomic analysis of spleen reveals key immune-related proteins in the yak (Bos grunniens) at different growth stages","volume":"42","author":"Zheng","year":"2022","journal-title":"Comp. Biochem. Physiol. Part D Genom. Proteom."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"19903","DOI":"10.1038\/s41598-024-69458-5","article-title":"Whole transcriptome sequencing revealed the gene regulatory network of hypoxic response in yak Sertoli cells","volume":"14","author":"Ma","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ma, R., Cui, Y., Yu, S.-J., Pan, Y.-Y., He, J.-f., Wang, Y.-y., Wang, J.-l., Wang, X.-y., Bai, X.-f., and Zhang, H. (2025). The glucose metabolism reprogramming of yak Sertoli cells under hypoxia is regulated by autophagy. BMC Genom., 26.","DOI":"10.1186\/s12864-025-11497-x"},{"key":"ref_9","first-page":"101686","article-title":"Transcriptome analysis reveals intestinal gene expression and metabolic pathways in yaks","volume":"57","author":"Luo","year":"2025","journal-title":"Comp. Biochem. Physiol. Part D Genom. Proteom."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/ng.2343","article-title":"The yak genome and adaptation to life at high altitude","volume":"44","author":"Qiu","year":"2012","journal-title":"Nat. Genet."},{"key":"ref_11","first-page":"72","article-title":"The transcriptomic landscape of yaks reveals molecular pathways for high altitude adaptation","volume":"11","author":"Qi","year":"2019","journal-title":"Genome Biol. Evol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language?","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrg.2015.10","article-title":"Unique features of long non-coding RNA biogenesis and function","volume":"17","author":"Quinn","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: Definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.molcel.2014.03.045","article-title":"Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance","volume":"54","author":"Denzler","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.celrep.2014.07.045","article-title":"Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes","volume":"8","author":"Ingolia","year":"2014","journal-title":"Cell Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6515","DOI":"10.1038\/s41467-022-34094-y","article-title":"Translation and natural selection of micropeptides from long non-canonical RNAs","volume":"13","author":"Patraquim","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"a032698","DOI":"10.1101\/cshperspect.a032698","article-title":"Ribosome profiling: Global views of translation","volume":"11","author":"Ingolia","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1016\/j.csbj.2024.04.051","article-title":"A review of Ribosome profiling and tools used in Ribo-seq data analysis","volume":"23","author":"Limbu","year":"2024","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Takele Assefa, A., Vandesompele, J., and Thas, O. (2020). On the utility of RNA sample pooling to optimize cost and statistical power in RNA sequencing experiments. BMC Genom., 21.","DOI":"10.1186\/s12864-020-6721-y"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/nprot.2012.086","article-title":"The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments","volume":"7","author":"Ingolia","year":"2012","journal-title":"Nat. Protoc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ymeth.2015.06.013","article-title":"Transcriptome-wide measurement of ribosomal occupancy by ribosome profiling","volume":"85","author":"Aeschimann","year":"2015","journal-title":"Methods"},{"key":"ref_24","unstructured":"Andrews, S. (2010). FastQC: A Quality Control Tool for High Throughput Sequence Data, Babraham Bioinformatics."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: A fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"ISCB Comm J-304","DOI":"10.12688\/f1000research.23297.1","article-title":"GFF utilities: GffRead and GffCompare","volume":"9","author":"Pertea","year":"2020","journal-title":"F1000Research"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: An efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Li, B., and Dewey, C.N. (2011). RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinform., 12.","DOI":"10.1186\/1471-2105-12-323"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"W12","DOI":"10.1093\/nar\/gkx428","article-title":"CPC2: A fast and accurate coding potential calculator based on sequence intrinsic features","volume":"45","author":"Kang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1093\/nar\/gkt646","article-title":"Utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts","volume":"41","author":"Sun","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Li, A., Zhang, J., and Zhou, Z. (2014). PLEK: A tool for predicting long non-coding RNAs and messenger RNAs based on an improved k-mer scheme. BMC Bioinform., 15.","DOI":"10.1186\/1471-2105-15-311"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/nar\/26.1.320","article-title":"Pfam: Multiple sequence alignments and HMM-profiles of protein domains","volume":"26","author":"Sonnhammer","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"W29","DOI":"10.1093\/nar\/gkr367","article-title":"HMMER web server: Interactive sequence similarity searching","volume":"39","author":"Finn","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"key":"ref_37","unstructured":"Li, H. (2013). Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM. arXiv."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/bib\/bbx014","article-title":"Circular RNA identification based on multiple seed matching","volume":"19","author":"Gao","year":"2018","journal-title":"Brief. Bioinform."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: A Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: A flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/15216540410001670142","article-title":"Structural aspects of microRNA biogenesis","volume":"56","author":"Krol","year":"2004","journal-title":"IUBMB Life"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/nar\/gkr688","article-title":"miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades","volume":"40","author":"Mackowiak","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: From microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_46","unstructured":"Gallopin, M. (2015). Classification et Inf\u00e9rence de R\u00e9seaux Pour Les Donn\u00e9es RNA-seq. [Ph.D. Thesis, Universit\u00e9 Paris Saclay (COmUE)]."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Peterson, S.M., Thompson, J.A., Ufkin, M.L., Sathyanarayana, P., Liaw, L., and Congdon, C.B. (2014). Common features of microRNA target prediction tools. Front. Genet., 5.","DOI":"10.3389\/fgene.2014.00023"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13040-014-0034-0","article-title":"Performance of genetic programming optimised Bowtie2 on genome comparison and analytic testing (GCAT) benchmarks","volume":"8","author":"Langdon","year":"2015","journal-title":"BioData Min."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","article-title":"Mapping and quantifying mammalian transcriptomes by RNA-Seq","volume":"5","author":"Mortazavi","year":"2008","journal-title":"Nat. Methods"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"eabj3967","DOI":"10.1126\/sciadv.abj3967","article-title":"Profiling and functional characterization of maternal mRNA translation during mouse maternal-to-zygotic transition","volume":"8","author":"Zhang","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Marques, T., and Gama-Carvalho, M. (2022). Network approaches to study endogenous RNA competition and its impact on tissue-specific microRNA functions. Biomolecules, 12.","DOI":"10.3390\/biom12020332"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s40104-024-01027-2","article-title":"Pangenome and multi-tissue gene atlas provide new insights into the domestication and highland adaptation of yaks","volume":"15","author":"Lan","year":"2024","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrg.2016.20","article-title":"Endogenous microRNA sponges: Evidence and controversy","volume":"17","author":"Thomson","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/10409238.2018.1447542","article-title":"Complexities of post-transcriptional regulation and the modeling of ceRNA crosstalk","volume":"53","author":"Smillie","year":"2018","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/j.celrep.2013.05.031","article-title":"Cellular source and mechanisms of high transcriptome complexity in the mammalian testis","volume":"3","author":"Soumillon","year":"2013","journal-title":"Cell Rep."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Hong, S.H., Kwon, J.T., Kim, J., Jeong, J., Kim, J., Lee, S., and Cho, C. (2018). Profiling of testis-specific long noncoding RNAs in mice. BMC Genom., 19.","DOI":"10.1186\/s12864-018-4931-3"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"110872","DOI":"10.1016\/j.ygeno.2024.110872","article-title":"Comprehensive analysis of differentially expressed mRNAs, circRNAs, and miRNAs and their ceRNA network in the testis of cattle\u2013yak, yak, and cattle","volume":"116","author":"Cao","year":"2024","journal-title":"Genomics"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Liu, H., Khan, I.M., Yin, H., Zhou, X., Rizwan, M., Zhuang, J., and Zhang, Y. (2021). Integrated analysis of long non-coding RNA and mRNA expression profiles in testes of calves and sexually mature Wandong bulls (Bos taurus). Animals, 11.","DOI":"10.3390\/ani11072006"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Khan, I.M., Liu, H., Zhuang, J., Khan, N.M., Zhang, D., Chen, J., Xu, T., Avalos, L.F.C., Zhou, X., and Zhang, Y. (2021). Circular RNA expression and regulation profiling in testicular tissues of immature and mature Wandong cattle (Bos taurus). Front. Genet., 12.","DOI":"10.3389\/fgene.2021.685541"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"D468","DOI":"10.1093\/nar\/gkae905","article-title":"LncPepAtlas: A comprehensive resource for exploring the translational landscape of long non-coding RNAs","volume":"53","author":"Zhou","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41420-024-02175-0","article-title":"Long non-coding RNA-encoded micropeptides: Functions, mechanisms and implications","volume":"10","author":"Xiao","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Liu, T., Wu, J., Wu, Y., Hu, W., Fang, Z., Wang, Z., Jiang, C., and Li, S. (2022). LncPep: A resource of translational evidences for lncRNAs. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.795084"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/s12276-024-01220-3","article-title":"Molecular mechanisms of circular RNA translation","volume":"56","author":"Hwang","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cell.2019.05.010","article-title":"The translational landscape of the human heart","volume":"178","author":"Witte","year":"2019","journal-title":"Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13048-018-0410-3","article-title":"MicroRNA-424\/503 cluster members regulate bovine granulosa cell proliferation and cell cycle progression by targeting SMAD7 gene through activin signalling pathway","volume":"11","author":"Pande","year":"2018","journal-title":"J. Ovarian Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1172\/JCI42980","article-title":"Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-\u03b1 isoforms and promotes angiogenesis","volume":"120","author":"Ghosh","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"La, Y., Ma, X., Bao, P., Chu, M., Guo, X., Liang, C., and Yan, P. (2023). Identification and profiling of microRNAs during yak\u2019s testicular development. BMC Vet. Res., 19.","DOI":"10.1186\/s12917-023-03602-7"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"19309","DOI":"10.1038\/s41598-020-73885-5","article-title":"Bovine hepatic miRNAome profiling and differential miRNA expression analyses between beef steers with divergent feed efficiency phenotypes","volume":"10","author":"Mukiibi","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"200782","DOI":"10.1016\/j.omton.2024.200782","article-title":"Noncoding RNA landscape and their emerging roles as biomarkers and therapeutic targets in meningioma","volume":"32","author":"Joshi","year":"2024","journal-title":"Mol. Ther. Oncol."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/4\/532\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:18:05Z","timestamp":1770700685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/4\/532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,8]]},"references-count":70,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["ani16040532"],"URL":"https:\/\/doi.org\/10.3390\/ani16040532","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,8]]}}}